What to Know about CFIUS

What happens when AI collides with salesmanship, streaming-era sports, and healthcare?In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of Cost Plus Drugs.Topics include fiery group chats and how dissent sharpens thinking, the sales playbook of modern politics, and concrete fixes for U.S. healthcare like ending PBM opacity, publishing real prices, and government-backed patient financing. Mark also explains how AI is pushing media from “social” to algorithmic, why he expects millions of models, and why ESOPs are an underrated wealth engine. He shares what he’d build today and weighs in on NBA economics under the new collective bargaining agreement.Timecodes: 00:00 Introduction 00:47 Salesmanship, Politics, and Social Media04:05 AI, Algorithms, and the Future of Media06:29 Fragmentation of Social Platforms09:04 Political Messaging & Economic Populism12:05 Wealth, Equity, and Employee Ownership16:39 AI’s Impact on Education and Healthcare21:32 Fixing the US Healthcare System29:39 Entrepreneurship in the Age of AI33:38 Business Success, Sports, and Investments35:32 NBA Economics and Team Building50:44 Personal Priorities & Closing Thoughts Resources: Find Mark on X: https://x.com/mcuban Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

9 Syys 1h 1min

Who’s speaking up for startups in Washington, D.C.?In this episode, Matt Perault (Head of AI Policy, a16z) and Collin McCune (Head of Government Affairs, a16z) unpack the “Little Tech Agenda” for AI- why AI rules should regulate harmful use, not model development; how to keep open source open; the roles of the federal government vs states in regulating AI; and how the U.S. can compete globally without shutting out new founders. Timecodes: 0:00 – Introduction 1:12 – Defining the Little Tech Agenda4:40 – Challenges for Startups vs. Big Tech6:37 – Principles of Smart AI Regulation9:55 – History of AI Policy & Regulatory Fears19:26 – The Role of Open Source and Global Competition23:45 – Motivations Behind Policy Approaches26:40 – Debates on Regulating Use vs. Development35:15 – Federal vs. State Roles in AI Policy39:24 – AI Policy and U.S.–China Competition40:45 – Current Policy Landscape & Action Plans42:47 – Moratoriums, Preemption, and Political Dynamics50:00 – Looking Forward: The Future of AI Policy56:16 – Conclusion & DisclaimersResources: Read the Little Tech Agenda: https://a16z.com/the-little-tech-agenda/Read ‘Regulate AI Use, Not AI Development : https://a16z.com/regulate-ai-use-not-ai-development/Read Martin’s article ‘Base AI Policy on Evidence, Not Existential Angst: https://a16z.com/base-ai-policy-on-evidence-not-existential-angst/Read ‘Setting the Agenda for Global AI Leadership’:https://a16z.com/setting-the-agenda-for-global-ai-leadership-assessing-the-roles-of-congress-and-the-states/Read ‘The Commerce Clause in the Age of AI”: https://a16z.com/the-commerce-clause-in-the-age-of-ai-guardrails-and-opportunities-for-state-legislatures/Find Matt on X: https://x.com/MattPeraultFind Collin on X: https://x.com/Collin_McCune

8 Syys 57min

Stainless founder Alex Rattray joins a16z partner Jennifer Li to talk about the future of APIs, SDKs, and the rise of MCP (Model Context Protocol). Drawing on his experience at Stripe—where he helped redesign API docs and built code-generation systems—Alex explains why the SDK is the API for most developers, and why high-quality, idiomatic libraries are essential not just for humans, but now for AI agents as well.They dive into:The evolution of SDK generation and lessons from building at scale inside Stripe.Why MCP reframes APIs as interfaces for large language models.The challenges of designing tools and docs for both developers and AI agents.How context limits, dynamic tool generation, and documentation shape agent usability.The future of developer platforms in an era where “every company is an API company.”Timecodes: 0:00 – Introduction: APIs as the Dendrites of the Internet1:49 – Building API Platforms: Lessons from Stripe3:03 – SDKs: The Developer’s Interface6:16 – The MCP Model: APIs for AI Agents9:23 – Designing for LLMs and AI Users13:08 – Solving Context Window Challenges16:57 – The Importance of Strongly Typed SDKs21:07 – The Future of API and Agent Experience24:45 – Lessons from Leading API Companies26:14 – Outro and DisclaimersResources: Find Alex on X: https://x.com/rattrayalexFind Jennifer on X: https://x.com/JenniferHliStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

6 Syys 26min

Taken from The Oprah Podcast, this special episode brings together Shaka Senghor, a16z cofounder Ben Horowitz, and Oprah Winfrey for a powerful conversation on resilience and transformation.Shaka, a resilience expert, motivational speaker, and bestselling author of Writing My Wrongs, shares his journey from incarceration to redemption along with insights from his new book, How to Be Free. Full of hard-earned wisdom and practical tools, it’s a guide for anyone seeking freedom in their own life.Timecodes: 0:00 Introduction 1:30 Shaka’s Journey: From Prison to Freedom4:10 The Power of Narrative and Mindset6:10 Active Journaling & Writing My Wrongs8:45 Escaping Life’s Hidden Prisons10:00 The Role of Forgiveness16:40 Healing Family Relationships21:00 Unconditional Forgiveness & True Freedom22:40 Resilience as a Spiritual Principle24:15 Mentorship & Meeting Ben Horowitz28:55 Lessons on Success and Failure30:20 The Meaning of a Pardon31:50 Life After Prison: Finding Joy in Freedom32:30 Advice for Listeners: How to Begin Your Own Journey35:15 Closing Thoughts Resources: Find Shaka on X: https://x.com/ShakaSenghoFind Ben on X: https://x.com/bhorowitzFind Oprah on Instagram: https://www.instagram.com/oprahpodcast/Listen to the full podcast:https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLIhttps://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

5 Syys 36min

Is non-consensus investing overrated—or the secret to venture returns?a16z General Partner Erik Torenberg is joined by Martín Casado (General Partner, a16z) and Leo Polovets (General Partner, Humba Ventures) to unpack the debate that lit up venture Twitter/X: should founders and VCs chase consensus, or run from it?They explore what “consensus” really means in practice, how market efficiency shapes venture outcomes, why most companies fail from indigestion, not starvation, and the risks founders face when they’re too far outside consensus. Timecodes: 00:00 Introduction 01:04 Defining Consensus and Market Efficiency06:30 The Role of Hot Rounds and Market Signals10:25 Founder Perspective: Risks of Non-Consensus13:19 Investor Perspective: Indigestion vs. Starvation18:28 Market Cycles & Sector Hype23:55 The Evolution of Venture Market Efficiency26:29 Case Studies & Personal Anecdotes33:02 Fund Size, Ownership, and the Impact on Strategy51:40 The Future of Venture: Multi-Stage vs. Seed Funds Resources: Find Leo on X: https://x.com/lpolovetsFind Martin on X: https://x.com/martin_casado Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

4 Syys 54min

Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms, the rise of AI infrastructure, and why today’s fiercest battles are often for talent, not market share.Timecodes:0:00 Introduction0:27 Importance of Media for VC3:50 Evolution of a16z7:00 Specialization10:32 Value of Distribution13:16 Staying Power in Infrastructure19:49 The Conflicts Dynamic26:32 State of Play in AI30:48 The Future of Coding34:58 Significance of Open Source39:48 Marc Andreessen’s Leadership44:02 The Only Sin in VC48:37 Scaling a Lot of Board SeatsResources: Listen to more from Uncapped: https://linktr.ee/uncappedpodFind Jack on X: https://x.com/jaltmaFind Uncapped on X: https://x.com/uncapped_podFind Martin on X: https://x.com/martin_casadoStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

3 Syys 53min

What if the future of media isn’t controlled by algorithms or legacy institutions—but by independent voices building directly with their audiences?In this episode, Erik Torenberg is joined by Chris Best, cofounder and CEO of Substack, along with a16z general partners Katherine Boyle and Andrew Chen.We trace the origin story of Substack and its cultural impact, including how it reinvented the business model for independent media. We also explore the evolution of blogging, the rebundling of media, and what the future holds as attention becomes the scarcest resource.Timecodes: 00:00 Introduction03:50 Origins of Substack06:29 The Evolution of Blogging & Media Models09:15 Direct Audience Connection & Platform Independence10:57 Vision for Substack & The Role of Algorithms21:06 Business Models: Ads, Subscriptions, and AI26:10 The Scarcity of Attention & Value of Good Content27:45 Unbundling, Rebundling, and the Future of Media Companies37:12 Academia, Books, and Changing Content Formats44:31 Substack’s Next Phase & Closing ThoughtsResources: Find Chris on Substack: https://cb.substack.com/Find Chris on X: https://x.com/cjgbestFind Andrew Chen on Substack: https://andrewchen.substack.com/Find Andrew on X: https://x.com/andrewchenFind Katherine on X: https://x.com/KTmBoyleFind Katherine on Substack: https://boyle.substack.com/Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

2 Syys 46min

Venture capital has powered companies like Facebook and TikTok—but what if that same urgency fueled America’s defense and industrial base? Katherine Boyle, General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, argues this is the biggest business opportunity of our time.In this conversation from The Shawn Ryan Show, Boyle discusses the rise of defense tech startups, why optimism drives her work, and how a new generation of engineers and founders is rethinking innovation and patriotism in America. Timecodes: 0:00 Introduction 0:41 Patriotism, Optimism, and American Innovation4:27 Startups vs. Legacy Primes in Defense10:08 Venture Capital’s Unique Incentives17:21 Katherine’s Backstory: Family & Upbringing21:07 The Decline of Community & Family Pillars23:23 Polarization, Religion, and Social Fabric26:16 America’s Birth Rate Crisis29:46 Cultural Shifts and the Family Structure42:01 Katherine’s Path: Journalism to Venture Capital1:06:06 Breaking into Silicon Valley1:18:06 Investing in Defense: The Anduril Story1:37:37 The American Dynamism Movement2:04:27 Manufacturing, Space, and the Future of Defense2:14:06 Espionage, China, and National Security2:37:38 The Attack on the American Family2:48:29 Cultural Change, Suffering, and Purpose2:55:30 Closing Thoughts Resources: Find Katherine on X: https://x.com/KTmBoyleShawn Ryan Show Links YouTube:  https://www.youtube.com/channel/UCkoujZQZatbqy4KGcgjpVxQ/joinListen on Apple: https://podcasts.apple.com/us/podcast/shawn-ryan-show/id1492492083Listen on Spotify: https://open.spotify.com/show/5eodRZd3qR9VT1ip1wI7xQ?si=7abec4d61c324b24 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

30 Elo 2h 51min