CMC sustains possible season-ending injury in 49ers’ blowout loss to Bills

Matt Maiocco and Jennifer Lee Chan break down the 49ers’ second blowout loss in as many weeks and news that Christian McCaffrey could be out for the rest of the season with a PCL injury. Matt and Jennifer also dissect whether San Francisco can turn this season around after another demoralizing loss or if it is time to look ahead to next season.

(2:00) Christian McCaffrey exits game early with possible season-ending PCL injury

(6:30) After back-to-back blowouts, are the 49ers the worst team in the NFL right now?

(9:00) Analyzing George Kittle’s lack of involvement in Sunday’s loss to Bills

(15:30) Can 49ers bounce back from back-to-back demoralizing losses?

(20:30) Discussing similarities between 2024 and 2020 seasons

(24:15) 49ers will be facing significant roster decisions after 2024 season