What “The 72-Hour Rule” Update Means for New York State

Effective February 19, 2026, New York State law permits clinicians to dispense up to 72 hours (equivalent to a 3-day supply) of controlled substances, such as methadone and buprenorphine, for the management of opioid withdrawal while arranging referral and linkage to care for persons with opioid use disorder, as authorized by federal regulations (specifically, the Code of Federal Regulations or CFR number 1306.07). The federal regulations were updated in August 2023, and New York State law is just now catching up. We informally refer to the update as “The 72-Hour Rule.”

Featuring Dr. Linda Wang, this episode reviews what this update means for New York State and how clinicians and healthcare administrators can think about its implementation.

Are you implementing “The 72-Hour Rule” in clinical practice in New York State? We want to hear from you! Please reach out to share your experience: Lauren.walker3@mountsinai.org. Related Content:

New York State Senate Bill S3416D: https://www.nysenate.gov/legislation/bills/2025/S3416/amendment/D
Code of Federal Regulations (CFR) § 1306.07: https://www.ecfr.gov/current/title-21/chapter-II/part-1306/subject-group-ECFR1eb5bb3a23fddd0/section-1306.07
Skogrand E, et al. (2024). Dispensing methadone at hospital discharge: One hospital’s approach to implementing the “72-hour rule” change. J Addict Med. 2024; 18(1):71-74. doi: 10.1097/ADM.0000000000001246.
Shahlapour M, et al. (2024). Novel uses of methadone under the “72-hour rule” to facilitate transitions of care and low-dose buprenorphine induction in an outpatient bridge clinic. J Addict Med. 2024; 18(3):345-347. doi: 10/1097/ADM.0000000000001281.
Taylor JL, et al. (2022). Bridge clinic implementation of "72-hour rule" methadone for opioid withdrawal management: Impact on opioid treatment program linkage and retention in care. Drug Alcohol Depend. 2022; 236:109497. doi: 10.1016/j.drugalcdep.2022.109497.
CEI Clinical Consultation Line 1-866-637-2342 A toll-free service for NYS clinicians offering real-time clinical consultations with specialists on HIV, sexual health, hepatitis C, and drug user health.
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