Special Episode: Lawrence Ingrassia & A Fatal Inheritance

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your lifetime, a condition known as Li-Fraumeni Syndrome. Journalist Lawrence Ingrassia belongs to one of those families; he has lost his mother, three siblings, and a nephew to cancer. In this TPWKY book club episode, Ingrassia joins me to discuss his book A Fatal Inheritance: How a Family Misfortune Revealed a Deadly Medical Mystery, where he weaves together his family’s story with that of the scientists who sought to uncover the cellular drivers of cancer. Tune in for a heartbreaking and inspiring journey.

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Jaksot(304)

Ep 222 Vitamin K: Calling the shots

Ep 222 Vitamin K: Calling the shots

Shortly after birth, many newborns are given vitamin K to help their blood clot properly and reduce the chances of hemorrhage. Increasingly, especially here in the US, parents are refusing this life-s...

22 Syys 1h 6min

Special Episode: Dr. Alanna Skuse & The Surgeon, The Midwife, The Quack

Special Episode: Dr. Alanna Skuse & The Surgeon, The Midwife, The Quack

Imagine yourself as a 17th century English peasant or merchant or noble. Let’s say you’re dealing with some intense stomach pain or a cut on your leg that won’t heal. Where do you turn to for help? To...

15 Syys 52min

Ep 221 Electroconvulsive Therapy Part 2: A current conversation

Ep 221 Electroconvulsive Therapy Part 2: A current conversation

This week, we’re picking up where we left off last episode in our exploration of ECT by examining how this therapy is administered, which conditions it’s used for, and what we know about why it works....

8 Syys 58min

Ep 220 Electroconvulsive Therapy Part 1: A charged history

Ep 220 Electroconvulsive Therapy Part 1: A charged history

For many, a mention of electroconvulsive therapy (ECT) conjures images of torture or mind control from popular media like One Flew Over the Cuckoo’s Nest or Requiem for a Dream. Comparatively few know...

1 Syys 50min

Special Episode: Clayton Page Aldern & The Weight of Nature

Special Episode: Clayton Page Aldern & The Weight of Nature

Already this summer, heatwaves are causing thousands of deaths across the world, catastrophic flooding threatens millions, wildfires rage across enormous swathes of the globe, many regions face extrem...

25 Elo 44min

Ep 219 The Brown Recluse: Fearsome foe or slandered spider?

Ep 219 The Brown Recluse: Fearsome foe or slandered spider?

Few spiders hold the dubious honor of name recognition among the general public. Most that do, like black widows, Australian funnel-web, the Goliath birdeater, are renowned not for their cute colors o...

18 Elo 58min

Special Episode: Deborah Cohen & Bad Influence

Special Episode: Deborah Cohen & Bad Influence

If you have a medical question, where do you turn? How often is google or social media your first stop? As you sift through the AI overview and countless reels professing to have the answers, it becom...

11 Elo 51min

Ep 218 The Lowdown on Statins

Ep 218 The Lowdown on Statins

Last week, we set the stage by breaking down the science behind cholesterol: how it moves through our body, why it causes disease, and when we discovered the link between LDL and atherosclerosis. This...

4 Elo 1h 10min

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