Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle
Unraveled15 Maalis 2023

Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle

Cancer is often a problem of cell division; cancer cells keep doubling and doubling, faster and faster. Eventually, they crowd out the healthy cells we need to survive. So researchers proposed a question: Why not stop that land grab? Why not find a way to jam the gears of the cell cycle to stop cancer cells from dividing? Today, we have drugs that do just that: They're called CDK-4/6 inhibitors. The story of those drugs, the momentum that brought them from bench to bedside, was written largely at Dana-Farber Cancer Institute — and keeps being written today. It's the story we're telling in episode three of Unraveled.

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Jaksot(15)

Season 3 Episode 1: Advances in Endometrial Cancer Research

Season 3 Episode 1: Advances in Endometrial Cancer Research

Cigall Kadoch had a hunch that the research in her lab might be relevant to endometrial cancer research. She had spent more than a decade studying the molecular machinery that unwinds DNA in the nucle...

1 Syys 19min

Season 2 Episode 6: Big Data, AI, and Cancer Research

Season 2 Episode 6: Big Data, AI, and Cancer Research

As our universe of knowledge expands, sometimes incrementally and more often, exponentially, its new dimensions create new challenges. The more we know, the better our tools are, the more choices we h...

17 Touko 202328min

Season 2 Episode 5: With a Little Help From My Friends: Combination Immunotherapy

Season 2 Episode 5: With a Little Help From My Friends: Combination Immunotherapy

If there is such a thing as a holy grail in cancer research, a secret spell or golden ring that can ward off any and all forms of the disease, it probably lives somewhere in the realm of immunotherapy...

26 Huhti 202332min

Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies

Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies

By the early 2000s, researchers at Dana-Farber and elsewhere knew that a certain protein appeared in many tumors taken from lung cancer patients. Based on that data, doctors started treating those pat...

5 Huhti 202330min

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Momentum isn't always one way. And it's not always constant. Sometimes it shoves you sideways, sometimes it stops you in your tracks. And sometimes only sometimes, it drives you to write one of the mo...

22 Helmi 202328min

Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction

Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction

The story begins decades ago with a man named Stanley Korsmeyer, who led the molecular oncology program at Dana-Farber from 1998 until his death in 2005. He discovered that B-cell cancers like CLL ove...

1 Helmi 202330min

Season 2 Trailer

Season 2 Trailer

In season 2 of Unraveled, we explore the theme of momentum. The momentum that takes therapies from test bench to bedside, and then back to test bench for fine tuning. The momentum provided by research...

27 Tammi 20232min

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