The Ovary’s Job Doesn’t End at Menopause: A Top Neuroscientist Explains

The Ovary’s Job Doesn’t End at Menopause: A Top Neuroscientist Explains

In this episode of unPAUSED, Dr. Mary Claire Haver talks with Dr. Jennifer Garrison, a neuroscientist and entrepreneur, about why the ovary should never have been labeled a purely reproductive organ. Dr. Garrison explains that ovaries function like a second brain in the body, sending and receiving chemical signals to nearly every tissue system including the heart, bones, brain, immune system, and metabolism. She walks through her research on the hypothalamus and the brain ovary signaling network, describing how inflammation in this part of the brain may be one of the earliest drivers of aging across the whole body.

The conversation covers why the ovary ages roughly two and a half times faster than the rest of the body, a gap that helps explain the health span difference between women and men. Dr. Garrison and Dr. Haver discuss how poor ovarian function shows up across a woman's life, not only at menopause, contributing to conditions like polycystic ovarian syndrome, infertility, early menopause, depression, metabolic disease, and autoimmune disease. They also unpack why autoimmune conditions rise sharply after menopause and why women's immune systems respond differently to viruses than men's.

Guest links:

Jennifer Garrison, PhD (LinkedIn)

Jennifer Garrison (X)

Jennifer Garrison (Bluesky)

Jennifer Garrison (X Prize)
Jennifer Garrison (The Institute)

Books

“The New Perimenopause,” by Dr. Mary Claire Haver

“The New Menopause"⁠ by Dr. Mary Claire Haver

For full show notes, please click here.

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Menopause Skin Changes and the Science of Skincare

Menopause Skin Changes and the Science of Skincare

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Dr. Erica Kelly, board-certified dermatologist, Clinical Professor at the University of Texas Medical Branch, and founder and director...

29 Syys 46min

Building Muscle in Menopause: Protein, Creatine and Strength Training with Dr. Gabrielle Lyon

Building Muscle in Menopause: Protein, Creatine and Strength Training with Dr. Gabrielle Lyon

In this episode of unPAUSED, Dr. Mary Claire Haver continues her conversation with Dr. Gabrielle Lyon, board-certified family physician, founder of the Institute for Muscle-Centric Medicine, and bests...

25 Syys 1h

Muscle is the Organ for Longevity with Dr. Gabrielle Lyon

Muscle is the Organ for Longevity with Dr. Gabrielle Lyon

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Dr. Gabrielle Lyon, board-certified family physician, founder of the Institute for Muscle-Centric Medicine, and bestselling author of ...

22 Syys 56min

Menopause Masterclass: Why Your Hair Is Thinning and What Works

Menopause Masterclass: Why Your Hair Is Thinning and What Works

In this solo episode of unPAUSED, Dr. Mary Claire Haver tells the truth about hair loss in women over 40 — a medical condition with real, identifiable causes, not a vanity complaint to be dismissed as...

15 Syys 51min

Melinda French Gates Is Fighting to Close the Menopause Funding Gap

Melinda French Gates Is Fighting to Close the Menopause Funding Gap

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Melinda French Gates, philanthropist and founder of Pivotal, to talk about her call for a "menopause revolution" — including the $215 ...

8 Syys 46min

Testosterone Is Not a Male Hormone: Levels, Dosing, and What It Does During Menopause

Testosterone Is Not a Male Hormone: Levels, Dosing, and What It Does During Menopause

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Dr. Mohit Khera, board-certified urologist and Professor of Urology at Baylor College of Medicine, where he holds the F. Brantley Scot...

1 Syys 1h 12min

Dr. Mary Claire Haver on Menopause: Recorded Live from LA with Dr. Rena Malik

Dr. Mary Claire Haver on Menopause: Recorded Live from LA with Dr. Rena Malik

This episode of unPAUSED was recorded live at the Wiltern Theater in Los Angeles in front of an audience gathered to talk about perimenopause, menopause, hormones, sex, brain health, and bone health. ...

25 Elo 1h 14min

Listen Again: Build Strength, Live Longer: The Menopause Longevity Blueprint with Dr. Vonda Wright

Listen Again: Build Strength, Live Longer: The Menopause Longevity Blueprint with Dr. Vonda Wright

What if weak bones and muscle loss aren't just "normal aging" but the result of decades of misinformation? In this episode double board-certified orthopedic surgeon Dr. Vonda Wright joins Dr. Mary Cla...

21 Elo 1h 21min

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