5 ways to control your blood sugar, reverse insulin resistance, and reduce your heart disease risk | Prof Rob Semple

5 ways to control your blood sugar, reverse insulin resistance, and reduce your heart disease risk | Prof Rob Semple

1 in 4 people have insulin resistance, which quietly raises your risk of heart disease and cancer, often without any change in your blood sugar. And most of those who have it have no idea. It can remain completely hidden for years, with no obvious symptoms and no warning signs… But it can be reversed. Today, Professor Rob Semple, a world-leading expert on insulin resistance, explains what insulin does in your body, why you need it to live, and what happens when it stops working properly. By the end of this episode, you will understand how to spot the warning signs and have practical steps you can take to protect yourself. If your last blood test came back "normal," how confident are you that it tells the whole story? Are you overlooking one of the biggest drivers of chronic disease? 🌱 Try our science-backed and tasty wholefood supplement Daily30 🌿Let your gut microbes snack on the ZOE Gut Health Bar Build healthy habits. Download the ZOE app today and start your trial for just £2.30 for your first week. 👉 Join ZOE Follow ZOE on Instagram. Timecodes 00:00 Intro 00:46 Why insulin might be the most important hormone in your body 01:53 What happens if your body stops making insulin 05:20 Why not having insulin used to be a death sentence 11:19 What happens to your brain when blood sugar drops too low 14:01 Why "just lower your insulin" advice can backfire 17:12 The shaky, sweaty feeling an hour after eating, explained 18:42 The exact moment insulin resistance turns into diabetes 21:47 Why high insulin can affect your ovaries 24:15 A visible skin sign that insulin levels are too high 25:40 The organs most at risk when blood sugar spirals 27:17 How common insulin resistance really is in the US and UK 30:23 Why your ovaries can be an early sign of insulin resistance 32:49 Debunking the online "signs" of insulin resistance 35:37 Is insulin resistance actually reversible? 36:47 Why your weight matters more than your BMI number 38:53 The DEXA scan that revealed hidden visceral fat 41:14 Why white bread might not be so different from a can of Coke 43:56 Why one type of exercise burns blood sugar best 45:17 Do you really need two hours in the gym to see results? 46:38 How stress directly changes your blood sugar 48:32 Why irregular sleep might be hurting your blood sugar 49:38 The one piece of advice for anyone worried about insulin resistance 55:00 Why insulin resistance may have once been a survival advantage 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati The Appetite Reset by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Good Mood Food (preorder) by Prof. Tim Spector Free resources from ZOE The Smart Snacking Guide: How to feed your gut, fuel your day, and snack without guilt The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra Eating for Better Brain Health: Your brain-gut blueprint How to eat in 2026 - Discover ZOE’s 8 nutrition principles for long-term health Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks Better Breakfast Guide Mentioned in today's episode Insulin resistance is a risk factor for 12 types of cancer, Nature (2026) Association of insulin resistance with cancer, American Journal of Cancer Research (2016) Global prevalence of insulin resistance, Frontiers in Endocrinology (2025) Risk Reclassification Beyond BMI, (JACC) (2026) Have feedback or a topic you'd like us to cover? Let us know here. Episode transcripts are available here.

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Inside Tim Spector’s weekly food shop - 6 grocery rules to lower your blood pressure, cholesterol, and heart disease risk | Prof Tim Spector & Prof Sarah Berry

Inside Tim Spector’s weekly food shop - 6 grocery rules to lower your blood pressure, cholesterol, and heart disease risk | Prof Tim Spector & Prof Sarah Berry

Supermarket shelves are full of foods promising to be healthy: high-protein, low-fat, gluten-free, sugar-free. How do you know what's true? Today, Professors Tim Spector and Sarah Berry, world-leadi...

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Most replayed moment: What your wearable is really telling you | Dr Malcolm Finlay

Most replayed moment: What your wearable is really telling you | Dr Malcolm Finlay

From smartwatches to fitness trackers, more of us than ever are monitoring our health in real time. With just a glance at our wrist, we can check our step count, sleep quality, heart rate and, more re...

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Is your gut the secret to anti-aging? 6 science-backed ways to boost your bone strength, muscle, and balance | Prof Elaine Dennison

Is your gut the secret to anti-aging? 6 science-backed ways to boost your bone strength, muscle, and balance | Prof Elaine Dennison

Picture the sound of a bone snapping - the kind of sound that makes you wince - and ask yourself how often you’ve thought about your bone health. Most of us only think about bone density when somethi...

17 Syys 55min

Most replayed moment: How to build a better breakfast | Prof. Ben Gardner & Tim Spector

Most replayed moment: How to build a better breakfast | Prof. Ben Gardner & Tim Spector

We’ve all heard the saying: Breakfast is the most important meal of the day. And while it may sound like a cliché, there’s some truth to it. Because for many of us, breakfast is the one meal we keep t...

15 Syys 14min

The science behind food that isn’t food, why you love it and why you should not fear it all | Prof Tim Spector & Prof Sarah Berry

The science behind food that isn’t food, why you love it and why you should not fear it all | Prof Tim Spector & Prof Sarah Berry

Are some of your "healthy" foods actually high-risk ultra-processed foods? For decades, nutrition advice seemed relatively straightforward. Eat less sugar. Less salt. Less saturated fat. Then it all...

10 Syys 1h 13min

Most replayed moment: The hormone that controls your weight | Dr Andrew Jenkinson

Most replayed moment: The hormone that controls your weight | Dr Andrew Jenkinson

Floating through all of our bodies is a complex network of hormones. You can think of it as an internal postal service, delivering vital messages and instructions to different organs and systems. But...

8 Syys 12min

The secret to coping with stress - how to protect your brain and body, and feel calmer now | Prof Carmine Pariante

The secret to coping with stress - how to protect your brain and body, and feel calmer now | Prof Carmine Pariante

Growing up, many of us were taught to just stay calm and carry on - as if stress was all in the mind, with no real effect on the body. But chronic stress can change your brain, raise your risk of hear...

3 Syys 59min

Most replayed moment: The hidden battle inside your gut | Tim Spector & Nicola Segata

Most replayed moment: The hidden battle inside your gut | Tim Spector & Nicola Segata

Today we’re talking about gut microbes. Professor Tim Spector often refers to the microbes in our gut as ‘mini pharmacies’. This is because they provide us with powerful chemicals that help support o...

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