SLU-PP-332 vs SLU-PP-915: The Science of the New Fat Loss Drugs, Dosing & Blood Work | Pharmacology Coach

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Max Bertolino runs compounds himself at the doses the studies actually used, then pulls blood. In this episode he and Drew go head to head on SLU-PP-332 vs SLU-PP-915 — why the reported dosing range on 332 spans a thousandfold, what actually happens at the top of that range, and why 915 appears to do the same job at a fraction of the dose with cleaner blood work and none of the hydrazide risk.

From there it opens into the rest of the new metabolic drugs. Max breaks down the estrogen-related receptor mechanism behind the exercise mimetics — why they shift fuel selection toward fat, why they drive GLUT4 and mitochondrial density independent of training, and why the gyno panic around 332 was never pharmacologically possible. He explains ATX-304 (O-304) as a pan-AMPK activator that keeps AMPK switched on by blocking the phosphatase that turns it off, and why twelve weeks at the clinical dose did nothing measurable to his hypertrophy despite everything the AMPK-versus-mTOR crowd predicted. He covers SANA (MVD1) and the futile creatine cycle — a compound whose entire mechanism is making your body waste its own energy accomplishing nothing — along with the phase one tolerability ceiling and the creatine-loading trick one user stacked on top of it.

The back half turns to what the community already runs and gets wrong. Why the SS-31 dose everyone uses was essentially picked out of the air, an order of magnitude below the studies. Why ACE-083 grows muscle volume without a matching increase in force output. Why Masteron's reputation has no pharmacological pedigree behind it. Why Boldenone is a better Primobolan than most people will admit, and why mirabegron and albuterol are the two most overlooked compounds in fat loss.

The through-line: almost every dose and every fear this community operates on was inherited rather than measured. And the single most practical warning in the hour — stack an exercise mimetic with ATX-304 while running a deep deficit on low carbs and fasted cardio, and the compounds are not what puts you on the floor. Your diet is.

TAKEAWAYS

• The dosing range on SLU-PP-332 spans a thousandfold. Only one end of it does anything.
• SLU-PP-915 does the same job at roughly a seventh of the dose — and the blood work comes back cleaner.
• Stack an exercise mimetic with ATX-304 and it won't be the compounds that put you on the floor. It'll be your diet.
• The SS-31 dose everyone runs is 2mg. The studies showing kidney benefit start at 40.
• Mirabegron is a bladder drug for old people. It burns 250 calories a day while you do nothing.

CHAPTERS

00:00 SLU-PP-332 vs SLU-PP-915: The Thousandfold Dosing Range

08:00 Why the Old Bodybuilding Compounds Are a Dead End

15:50 How Exercise Mimetics Work: ERR Activation, GLUT4 & Going Hypo

26:13 ATX-304: Pan-AMPK Activation & the Muscle-Loss Fear

33:31 Stacking ATX With SLU, MOTS-c Redundancy & the SS-31 Dose

41:16 SANA & the Futile Creatine Cycle

48:04 Myostatin Inhibition: ACE-083, Follistatin-344 & Cosmetic Muscle

56:05 Masteron, Anavar & Anadrol: What Still Earns Its Place

1:04:58 Boldenone, Beta-3 Agonism & Albuterol Over Clen

1:12:40 Where to Find Max Bertolino

FIND MAX BERTOLINO — all links verified against his own site, not taken from the transcript

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