Episode 37: Xenotransplantation Updates from the Transplantation Journal

Original Air Date: Wednesday, May 21, 2025 Moderators Jennifer Li, Australia Jonathan Bromberg, United States Muhammad Mohiuddin, United States Speakers Wayne J. Hawthorne, Australia Raphael Meier, United States Jay Fishman, United States Robin K. Avery, United States Leo Bühler, Switzerland 📑 Overview Join our panel of experts who discuss important topics in Xenotransplantation. This panel discussion is complemented by a series of related articles recently published in Transplantation Journal. 🎯 Outline Wayne J. Hawthorne, Australia International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation (https://pubmed.ncbi.nlm.nih.gov/40198...) -- How xenotransplant research started and what are the major barriers to success. -- Research and innovation – haem & immunological barriers, genetic engineering etc. Raphael Meier, United States International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation (https://pubmed.ncbi.nlm.nih.gov/40197...) -- Key clinical trials in xenotransplantation. -- Issues with rejection and infection. -- Promise and what are the questions still to be answered moving forward. Jay Fishman, United States International Xenotransplantation Association (IXA) Position Paper on Infectious Disease Considerations in Xenotransplantation (https://pubmed.ncbi.nlm.nih.gov/40198...) -- What are the major zoonotic infections which have been encountered so far? -- What challenges exist in diagnosis/treatment of these? -- What are the current tools and research pipelines to help address this problem? Robin K. Avery, United States Optimizing IVIg in Xenotransplantation: A Call to Action (https://pubmed.ncbi.nlm.nih.gov/40164...) -- What role does IVIG have in xenotransplantation? -- What is the concern about using IVIG and what can be done to address these? Leo Bühler, Switzerland The International Human Xenotransplantation Inventory: Current Data and Future Directions (https://pubmed.ncbi.nlm.nih.gov/40197...) -- How can global efforts be best focused to moving the field forward? -- Discussion around key aspects of a xenotransplantation inventory and data harmonisation. -- Development of guidance, regulatory oversight and ethics in the field. 🔔 Don’t forget to like, share, and subscribe to the TTS channel for more education content. ℹ️ About The Transplantation Society (https://www.tts.org): The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission includes the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice. The official Journal of The Transplantation Society. Transplantation (https://transplantjournal.com) is published monthly and is a highly cited and influential journal in the field, with more than 25,000 citations per year. - Twitter: https://x.com/ttsorg Linkedin: / thetransplantationsociety