Can Spermidine Slow Aging? | Leslie Kenny | S9 - E20

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What if your cells had their own cleanup crew?

This week, Dr. Stephen Barrett sits down with Leslie Kenny—CEO of Oxford Healthspan and co-founder of the Oxford Longevity Project—to explore the science of spermidine, autophagy, and healthy aging.

At just 39, Leslie was diagnosed with both rheumatoid arthritis and lupus during her fifth round of IVF. Refusing to accept a bleak prognosis, she embarked on a journey through immunology, longevity research, and lifestyle medicine that ultimately led her to one of the most fascinating compounds in aging science: spermidine.

In this episode:

➡️What autophagy is and why it declines with age
➡️The Nobel Prize–winning science behind cellular recycling
➡️Senescent "zombie" cells, SASP, and chronic inflammation
➡️Why spermidine is considered a senomorphic rather than a senolytic
➡️Natural food sources of spermidine and the story behind Primadine
➡️The vagus nerve, ACE scores, thyroid health, and intergenerational stress

If you're interested in longevity, cellular health, inflammation, or evidence-based healthy aging, this episode is packed with practical insights and cutting-edge research.

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Timestamps:
00:00 Cold Open — Meet Leslie Kenny
01:32 Leslie's Origin Story
02:12 Diagnosed with RA & Lupus at 39
07:12 Throw the Kitchen Sink at It
08:50 IVIG & Immune Balance
11:25 When Evidence Isn't "Significant"
12:19 Inflammaging & Lifestyle Reset
15:00 Labs Return to Normal
16:20 Why Doctors Miss the "Why"
17:55 Motherhood & Oxford Connections
19:45 ValAsta Sponsor
20:36 Discovering Spermidine
22:32 Vagus Nerve & RA
25:48 Trauma, Vagal Tone & Inflammation
26:35 The ACE Test Explained
29:01 Paths to Remission
30:43 Treating Root Causes
33:10 Famine, Trauma & Thyroid
35:06 Hashimoto's & Fertility
37:29 What Is Autophagy?
38:39 BBACK Sponsor
39:31 The Nobel Prize for Autophagy
40:46 Zombie Cells, SASP & Senomorphics
45:23 The Molecules We Lose With Age
45:55 Where Spermidine Comes From
46:21 The Story Behind Primadine
47:55 Best Dietary Sources
49:30 Why Japan? Clean Sourcing Explained
51:55 Easy Ways to Take Spermidine
52:42 A Gluten-Free Spermidine Option
53:30 Oxford Longevity Project & POI15
55:37 Final Thoughts
56:31 Outro

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#longevity #autophagy #spermidine #healthyaging #cellularhealth #podcast #science #wellness