Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia
ESICM Talk19 Tammi 2022

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia

Systemic corticosteroids decrease mortality in critically ill patients with COVID-19, and the World Health Organization, therefore, recommends dexamethasone 6 mg daily for up to 10 days for patients with severe or critical COVID-19. In addition, higher doses of systemic corticosteroids have been used in patients with COVID-19 and non-COVID-19 acute respiratory distress syndrome [3, 5, 6], and higher doses have been hypothesised to benefit patients with severe or critical COVID-19. However, the balance between benefit and harm remains uncertain.

The COVID STEROID 2 trial compared a higher (12 mg) versus recommended dose (6 mg) of dexamethasone daily, for up to 10 days, in patients with COVID-19 and severe hypoxaemia.

Dr Granholm was interviewed by ICM Associate Editor Dr Shankar-Hari about the methodology and the findings of the study.

Original paper: Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial

Speakers

Anders GRANHOLM. Department of Intensive Care, Rigshospitalet—Copenhagen University Hospital (DK) and Collaboration for Research in Intensive Care (CRIC), Copenhagen (DK).

Manu SHANKAR-HARI. Usher Institute, University of Edinburgh (UK) and Centre for Inflammation Research, University of Edinburgh (UK)and School of Immunology and Microbial Sciences, King's College London, (UK). ICM Associate Editor.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(101)

2025 ESICM guidelines on circulatory shock and haemodynamic monitoring

2025 ESICM guidelines on circulatory shock and haemodynamic monitoring

What has changed in the 2025 ESICM guidelines on circulatory shock and haemodynamic monitoring, and what does it mean for clinical practice?In this podcast, our guest, Dr Antonio Messina, Chair of the...

23 Syys 32min

Drug Clearance in RRT: What Are the Determinants?

Drug Clearance in RRT: What Are the Determinants?

How do you optimise drug dosing in a critically ill patient undergoing continuous renal replacement therapy (CRRT)? Drug dosing during CRRT can be challenging, with multiple factors influencing drug c...

14 Syys 54min

2026 World Sepsis Day: From Awareness to Action

2026 World Sepsis Day: From Awareness to Action

This year, ESICM is proud to mark World Sepsis Day with a special podcast, "From Awareness to Action," featuring ESICM President Jan De Waele in conversation with Krista Bracke, sepsis survivor and ad...

12 Syys 43min

Heatstroke

Heatstroke

Why should every ICU clinician be prepared to recognise heat stroke?In this podcast, we explore the importance of early recognition and treatment of heat stroke, from the emergency department to the I...

26 Elo 30min

Is the curtain falling on pre-hospital whole blood?

Is the curtain falling on pre-hospital whole blood?

Whole blood has made a remarkable comeback in trauma care—but is it here to stay? In this thought-provoking podcast, leading experts unpack the latest evidence comparing whole blood with component the...

6 Heinä 25min

Switching from controlled to assisted ventilation: evidence, risks, and opportunities in AHRF?

Switching from controlled to assisted ventilation: evidence, risks, and opportunities in AHRF?

What are the benefits of moving from controlled to assisted mechanical ventilation in patients with Acute Hypoxemic Respiratory Failure (AHRF)? In this podcast, experts discuss the physiological ratio...

8 Kesä 38min

Biomarkers in Severe Infections and Sepsis - Moving from Trials to the Bedside

Biomarkers in Severe Infections and Sepsis - Moving from Trials to the Bedside

Sepsis care is evolving fast. Are you keeping up? Don’t miss this podcast episode, where we explore the latest clinical trials reshaping antibiotic therapy for severe infections, from optimised treatm...

27 Touko 25min

Advanced Practice in Nursing and Allied Health Professionals

Advanced Practice in Nursing and Allied Health Professionals

What does advanced practice really look like in the ICU? In this podcast episode, we are joined by two advanced intensive care practitioners who share their roles, career journeys, and impact within t...

13 Touko 43min

Suosittua kategoriassa Liike-elämä ja talous

sijotuskasti
vallattomat
psykopodiaa-podcast
mimmit-sijoittaa
rss-rahapodi
rss-oivalluksia-rahasta-elamasta
rss-hereilla
hyva-paha-johtaminen
ostan-asuntoja-podcast
rss-sisalto-kuntoon
rss-sami-miettinen-neuvottelija
rss-porssipuhetta
rss-rahamania
rss-bisnesta-bebeja
rss-karon-grilli
rss-startup-ministerio
rss-paasipodi
rss-hilden-kaira
rss-alanvaihtajat
rss-20-30-40-podcast