a16z Podcast: The Science and Business of Innovative Medicines

It’s a problem most entrepreneurs would love to face, a massive valuation offer from investors for the startup they’ve been killing themselves over. But what terms come along with that big number? In this segment a16z’s Scott Kupor is joined by two startup CEOs to pick apart the topic of valuations – serial entrepreneur Danny Shader, founder of PayNearMe, and Danielle Morrill, co-founder of Mattermark.

8 Syys 201425min

Profitless Ponzi scheme, or the greatest company in the world led by an absolute genius? Amazon is a polarizing company. Quarter after quarter, as it grows ever larger gobbling up categories and adding businesses, Amazon manages to produce exactly no profit. It’s as if its founder and CEO Jeff Bezos engineered it that way. He has, and Bezos will continue on the same profitless path, says Benedict Evans in conversation with Ben Horowitz in this segment of the a16z podcast. Benedict and Ben (yeah, we know, two Bens) examine the company Bezos has constructed, and why, for Bezos at least as opposed to nervous investors, it works so well. How one of the world's great founders gets away with building a massive public company his way. Be sure to check out Benedict's post on the topic for all the charts and numbers: http://a16z.com

5 Syys 201417min

Given that physical retail is expensive, what’s the right distribution mix for startups? In this podcast with Tristan Walker (who is building health and beauty brand Walker & Company from scratch), we hear Ron Johnson's lessons learned from arguably the world’s most successful physical retail outlet: the Apple Store -- as well as a discussion of the challenges of brand and retail in a multichannel world. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

3 Syys 201427min

Teenage siblings Ima, Asha and Caleb Christian from Atlanta, Georgia join Ben Horowitz for a discussion about the motivation and origins of their new app, Five-O. In the aftermath of the tragedy in Ferguson, Missouri, the young developers built Five-O as a tool to rate and document interactions -- good and bad -- with the police. Ben and the Five-O team discuss the origins and technical underpinnings of the app. Rapper Nas makes an appearance, offering his own experience with the police, and why efforts like Five-O work towards a solution that both citizens and police should get behind. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

28 Elo 201413min

The five-year anniversary segment with a16z founders Ben Horowitz and Marc Andreessen picks up with a discussion of Clayton Christensen's theories around disruption. Why Christensen's thinking is very much on the mark today, and how his theories help guide the firm in making decisions about what NOT to invest in. Ben offers one of the things he wished he had known as a young CEO, and Marc describes a trait that every great entrepreneur possesses. Part two of two.

26 Elo 201416min

Around the firm we use “software eats the world” as a guide for how technology will impact every industry and every person – from education to healthcare and government. As a16z marks its five-year anniversary, we turned to the fellow who came up with the thesis, Marc Andreessen, to explain how it’s rippling around the globe. And to break down all the implications for building companies and managing people we tapped a16z's cofounder Ben Horowitz. With both “a” and “z” in the room, this segment takes stock of the technology industry and startup ecosystem – from entrepreneurs to investors, and where it’s all headed next. Part one of two.

25 Elo 201427min

Jim Barksdale in the run-up to the Netscape IPO told potential investors that you can make money in software in two ways: bundling and unbundling. Benedict Evans and Steven Sinofsky revisit that thesis in the context of a mobile app world -- how Facebook for example, is unbundling itself, while at the same time Baidu is bundling everything together as fast as it can. How and why Barksdale's thesis is very much alive and well in the mobile world. All that, and the proper use of "fissiparousness" in a sentence.

15 Elo 201419min

Peter Levine goes deeper into the changing nature of the data center with Yoram Novick, CEO of Maxta, and Florian Leibert, CEO of Mesosphere. Does ARM architecture, the foundation of the chips in practically every mobile phone, have what it takes to displace X86 processors in the data center? Is the private cloud --- effectively a company operating its own data center -- dead, or will a hybrid public/private cloud model dominate? Given all the upheaval in the data center how do startups fit into the equation, and how are they competing today with legacy technologies and companies? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

31 Heinä 201422min