World’s Largest Supercomputer v. Biology’s Toughest Problems
a16z Podcast14 Kesä 2020

World’s Largest Supercomputer v. Biology’s Toughest Problems

Proteins are molecular machines that must first assemble themselves to function. But how does a protein, which is produced as a linear string of amino acids, assume the complex three-dimensional structure needed to carry out its job?

That's where Folding at Home comes in. Folding at Home is a sophisticated computer program that simulates the way atoms push and pull on each other, applied to the problem of protein dynamics, aka "folding". These simulations help researchers understand protein function and to design drugs and antibodies to target them. Folding at Home is currently studying key proteins from the virus that causes COVID-19 to help therapeutic development.

Given the extreme complexity of these simulations, they require an astronomical amount of compute power. Folding at Hold solves this problem with a distributed computing framework: it breaks up the calculations in the smaller pieces that can be run on independent computers. Users of Folding at Home - millions of them today - donate the spare compute power on their PCs to help run these simulations. This aggregate compute power represents the largest super computer in the world: currently 2.4 exaFLOPS!

Folding at Home was launched 20 years ago this summer in the lab of Vijay Pande at Stanford. In this episode, Vijay (now a general partner at a16z) is joined by his former student and current director of Folding at Home, Greg Bowman, an associate professor at Washington University in St. Louis, and Lauren Richardson. We discuss the origins of the Folding at Home project along with its connection to SETI@Home and Napster; also the scientific and technical advances needed to solve the complex protein folding and distributed computing problems; and importantly what does understanding protein dynamics actually achieve?

Jaksot(918)

The Future of Audio

The Future of Audio

Audio is no longer just audio anymore -- podcasts now pull from new video platforms like TikTok and older ones like radio, user experience is growing and changing, and it's easier than ever to create audio content. Where do all these mediums converge and where do they diverge -- when it comes to user experience, product design, recommendations, discovery, and more?In this episode from October 2020, a16z general partner Connie Chan and Spotify’s chief R&D officer Gustav Söderström join host Sonal Choksi to discuss the past, present and future of audio. They dig into everything from what the past in radio can tell us about the future, what audio can and will borrow from mediums like video and platforms like TikTok, the role for more interactivity and increased use of tools like machine learning and AI, and more.

14 Loka 202257min

Culture as Code

Culture as Code

While building and shaping culture is as relevant as ever for startups and companies today, leaders have sought the answers to these questions for hundreds of years – and there is practical advice to be had by examining different cultures across time and around the globe.In this episode from December 2019, a16z co-founder Ben Horowitz sits down with host Sonal Choksi to talk about what actually makes up culture, whether in a company or any organization or team, as based on Ben’s best-selling book, What You Do is Who You Are. They discuss the idea of culture as code, the nuances of setting and changing a culture, and how to apply the principles of his book to startups, the tech industry and any company today.

6 Loka 202259min

On Mentorship and Leadership

On Mentorship and Leadership

Behind many great leaders, you’ll usually find a great mentor. The mentor-mentee relationship is often one of the most important and most fulfilling relationships people have, in both their careers and in their lives. So how do you find a mentor? What are different kinds of mentorship? And how can it help you break into an industry – or help others break in themselves?In this episode from July 2018, a16z co-founder Ben Horowitz discusses mentorship with his mentor, Silicon Valley pioneer Ken Coleman, and Ben’s mentee, Michel Feaster, founder of Usermind and now Chief Product Officer at Qualtrics. They begin with their personal journeys and share advice and frameworks for mentorship, leadership, and growing as a founder.

28 Syys 202233min

Cloud Wars, Company Wars, and Innovating Through Change

Cloud Wars, Company Wars, and Innovating Through Change

In this episode from October 2021, Michael Dell, founder and CEO of Dell Technologies and one of the longest serving founder-CEOs in the technology industry, joins a16z general partner Martin Casado, a16z co-founder Marc Andreessen, and host Sonal Choksi on the occasion of Michael’s book, Play Nice to Win: A CEO’s Journey from Founder to Leader. There are lots of challenges in being public while trying to innovate, and limits to being a private company as well; but it's rare to see a company go public then private then back to public again. As is the case with Dell Technologies, one of the largest tech companies -- which went private 2012-2013 and then also pulled off one of the most epic mergers of all time with Dell + EMC + VMWare 2015-2016 (and which we wrote about here at the time).Is there a method to the madness? How does one not just start, but keep, and transform, their company and business? Michael, Marc, Martin and Sonal debate these questions, as well as the impact of the cloud wars, how innovation happens when a company is private and when its public (something Michael knows well, having taken Dell public to private to back to public again), whether you can actually play nice to win as a leader, and more.

7 Syys 202253min

How to Find Product-Market-Sales Fit

How to Find Product-Market-Sales Fit

In this episode from February 2019, Jyoti Bansal, founding CEO of AppDynamics and co-founder of Unusual Ventures, joins a16z general partner Peter Levine, a16z partner Sateesh Talluri, and host Sonal Choksi to discuss how product and sales evolve together for enterprise go-to-market, including key milestones for both product development and marketing, frameworks for how to think about pre- to post-product market fit, the role of additional levers like services or pricing, and more.For the show transcript, you can go here.

3 Syys 202251min

The Fintech Opportunity for Students and Gen Z

The Fintech Opportunity for Students and Gen Z

This week, student loans are back in the news, with the administration's announcement of a plan to forgive student loan debt for certain kinds of borrowers. Outside of the specific policies, though, student loans are often the first of many big financial decisions that young people make as they begin to build credit history and join the labor force. So what role can technology play in serving this demographic's particular needs, now and into the future?In this episode from October 2020, Amira Yahyaoui, the founder and CEO of Mos, a platform that helps students with their banking needs, like getting financial aid for college, joins a16z general partner Anish Acharya, partner Seema Amble, and host Lauren Murrow to discuss fintech for Gen Z and millenials. They dig into some of the issues around student loans today, the underserved banking needs of this group, and how fintech can help younger consumers today as well as set them up for a better financial future.

26 Elo 202230min

How to Make Better Decisions

How to Make Better Decisions

Can you get better at decision-making with practice? Many founders, investors, and builders must make many critical decisions, big and small, every day, and improving the quality of your decision-making process can become a big competitive advantage. In this episode from October 2020, expert decision strategist, author and professional poker player, Annie Duke, joins a16z managing partner Jeff Jordan, to discuss some of the frameworks, strategies, and tactics for better decision-making by both individuals and organizations that she outlines in her second book, How to Decide. This was Annie’s second appearance on the podcast – she first joined a16z co-founder Marc Andreessen and host Sonal Chokshi to discuss her first book, Thinking in Bets, where they  went deep into how to frame taking risks and placing bets, especially in the context of innovation. You can read the full transcript of this episode here, and you can read the transcript of Annie's first episode on the a16z Podcast with Marc Andreessen here.

19 Elo 202245min

Learning from Open Source Communities

Learning from Open Source Communities

What can we learn from the evolution of open source communities and how might they be applied to online communities and the creator economy today? Author Nadia Asparouhova joins host Sonal Choksi to talk about Asparouhova's book, Working in Public: The Making and Maintenance of Open Source Software, from Stripe Press.They start with a  a taxonomy for communities, and then dig into how open source has changed over time, which learnings from open source do and don’t apply to new communities online, how communities intersect with the growing desire for more "high-shared context" groups and spaces (including even podcasts and newsletters), and more.

11 Elo 202247min

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