262. Can injured 49ers slow Saints’ offense and pull off a Week 10 upset?

On this episode of 49ers Talk, Matt Maiocco and Laura Britt break down the 49ers' Week 10 matchup against Drew Brees and the New Orleans Saints and how injuries still are hampering the team’s success this season. Then, 49ers analyst Takeo Spikes joins the show to detail how the defense can slow the Saints’ offense and why Fred Warner is the key to victory this weekend.

(3:45) 49ers headed to New Orleans to face Saints

(7:16) Injuries hampering 49ers season

(11:44) Pro Football Focus released midseason All-Pro list

(18:57) Spikes shares his thoughts on Garoppolo’s future

(23:50) How can the 49ers slow down Kamara?

(26:40) Spikes discusses Warner’s impact