Are 49ers ready for prime time vs. Bills with odds stacked against them?

49ers: Shortly after Ohio State defensive end Nick Bosa was chosen as the No. 2 overall draft pick, he joined Matt Maiocco from the NFL draft in Nashville, Tenn.

26 Huhti 201912min

49ers: Defensive end Arik Armstead, who enters his fifth NFL season after being a first-round draft pick, talks about his role in the team's defense and his off-field interests, including his Sacramento-based foundation.

23 Huhti 201931min

49ers: Agent Leigh Steinberg talks about his approach in the days leading up to the NFL draft. Then, Matt Maiocco and Laura Britt discuss Nick Bosa and whether there should be any concern from his future NFL employer.

16 Huhti 201935min

49ers: After a strong rookie season, Fred Warner has high expectations for himself and the team. He is eager to play alongside Kwon Alexander, a player he spent a lot of time studying long before they became NFL teammates.

10 Huhti 201933min

49ers: Suzy Kolber of ESPN talks about how she developed her love of football as a young girl. She also describes what she saw from the 49ers last season from Kyle Shanahan and John Lynch as the team went through a difficult, injury-plagued season.

2 Huhti 201930min

49ers: Matt Maiocco talks with Jennifer Lee Chan and Laura Britt about the experiences and information gathered at the NFL owners meeting in Arizona, as well as visits with Nick Bosa and Josh Allen at the pro days of Ohio State and Kentucky.

26 Maalis 201928min

The San Francisco 49ers kicked off the free-agent signing period with the addition of former Tampa Bay linebacker Kwon Alexander, who reflects on the journey he has taken to get to this point in his career and life.

19 Maalis 201927min

49ers: Agent Don Yee represents Jimmy Garoppolo, Tom Brady and others. He is also the founder of a new professional football league that will kick off next summer that is designed as an alternative to college football.

12 Maalis 201933min