Who Will Own the Internet? a16z’s Chris Dixon on AI and Crypto

mRNA research before COVID and how "mRNA is code" [3:21]The early days of COVID: designing a vaccine in 48 hours [5:44]The software behind the vaccine: getting mRNA researchers out of Excel and into a drug design studio [9:11]The first draft of the vaccine was the final draft [11:10]How the government sped up vaccine development for COVID [12:18]What other new vaccines will come from mRNA?  [15:34]How far are we from these mRNA vaccines? What do we need for them to be widely available? [25:31]Open sourcing Moderna  [27:53]When will COVID vaccines be available for a five year old? [29:47]The three factors that matter when dealing with COVID variants [30:46]How might open source shake up biotech [36:41]The moonshot applications for mRNA therapeutics  [39:43]Advice for building a new category in a regulated environment [46:49]The clinical or regulatory advances needed to speed drug time to market [51:08]Challenge trials for vaccines: good or bad idea? [59:11]It's Time to Heal, Mondays at 5pm PT on Clubhouse. Join the a16z bio team — Jorge Conde, Vineeta Agarwala, Julie Yoo, and Vijay Pande — plus special guests as they explore all the ways that biology is technology.

11 Kesä 20211h 7min

Fab 5 Freddy on New York in the 70s, Warhol, Blondie, Basquiat, and Yo! MTV Raps [1:40]Contrarian strategy and challenging assumptions [5:12]Boring AI and solving meaningful problems [8:42]Drop-in audio copycats [14:39]How is copying software different from remixing hip hop? [21:07]Do you want a CEO as an inventor or an operator? [24:12]Recruiting sales development reps [30:34]Being a boss and having a personal life [36:56]How do you tell the story of letting someone go? [42:47]Best practices for delegating responsibility [49:46]Worst boss advice Ben and Ali have received [57:15]Boss Talk is the Clubhouse show where a16z cofounder Ben Horowitz and Ali Ghodsi, the Founder/CEO of Databricks, discuss CEO stuff, leadership stuff, management stuff... boss stuff. Live every Tuesday 5-6pm on Clubhouse. For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse.

28 Touko 20211h

The six functions in an enterprise marketing org [2:54]Why product marketing is the killer function [6:52]How do you hire a world class product marketer? [11:16]Is community or developer evangelists its own function or part of product marketing? [17:46]How does community tie into the marketing funnel? [22:56]Is community top of funnel, an accelerant for the whole funnel, or something else entirely? [29:39]If the product you're selling becomes someone's job, then your community marketing is working. [32:40]Plugging the community into sales... is there a tool for that? [34:29]How do all the different marketing tools come together? Do you need engineers in marketing? [39:24]How do you make marketing data-driven? [41:56]Building marketing in the early stages [50:06]Inside sales, field sales, product-led, channel sales, marketing, post-sales… On a16z GTM, David Ulevitch talks to builders about what it takes to go to market, and the evolving strategies and lessons learned from enterprise companies past and present. Every other Thursday 4-5pm.For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse.

24 Touko 202159min

What did Substack think about the NYTimes article "Why We’re Freaking Out About Substack" [1:01]What is Substack? [4:40]The issues with social media content models and how Substack is different [5:54]What about the echo chamber? [8:54]Turning cultural principles (e.g., freedom of the press) into actual culture [12:00]Will Substack replace traditional media? [14:01]Would Donald Trump be welcome on Substack? [20:35]Why do they pay writers advances? And why is that controversial? [23:33]The origins of American journalism aren't what most people think [27:20]Non-fungible writers and the Substack model [31:45]Ad-supported media predates the internet  [39:21]How do I price my Substack? [43:39]Substack, political topics, and culture wars: "We knew we were running towards the fire." [45:01]How do you prevent algorithms from slanting the platform [51:06]Substack's vision for the future of media [55:27]Boss Talk is the Clubhouse show where a16z cofounder Ben Horowitz and Ali Ghodsi, the Founder/CEO of Databricks, discuss CEO stuff, leadership stuff, management stuff... boss stuff. Live every Tuesday 5-6pm on Clubhouse. For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse.

21 Touko 202158min

eBay to today, a brief history of collectibles and tech [1:03]Are collectibles about sentiment or investment? [5:13]How do you bring the excitement of a collection to digital goods? [13:34]Is the future of all collectibles digital? [20:20]The role of blockchain and NFTs [26:39]Are collectible marketplaces different from other marketplaces? [32:19]Importance of live video [38:28]Celebrity interest in NFTs: will it last? [40:46]Are collectibles a bubble? [43:13]Listen live to the a16z show People Behind the Product Wednesdays noon-1pm PT with the a16z consumer team.

20 Touko 202153min

For videos of the NFT Virtual Summit, visit a16z.com. Session 1: The Future of the Digital Ownership Economy with Dan Boneh (Stanford University) and Chris Dixon (a16z)What is an NFT? [3:01]Why are NFTs  so big right now? [7:04]The most exciting programmable ownership structures  [11:36]NFTs and composability: what can  you do with NFTs? [15:16]How would quantum impact the immutability of the blockchain ledger? [18:40]How important is decentralized permanent storage for NFTs... and when will we get there? [20:54]Session 2: The New Creative Economy with Kayvon Tehranian (Foundation Labs)How Foundation Labs works with creatives [24:54]Digital Art NFTs: Nyan Cat, Ethiopian Artists Collective, Rafael Rozendaal, Aphex Twin, and Reuben Wu [28:08]The Edward Snowden NFT [33:45]Why is tracking provenance powerful for creatives? [36:34]Creators becoming collectors and crypto investors [39:00]Can you buy an NFT on one platform and sell on another and still track provenance? [41:31]Session 3: NBA Top Shot and Other NFTs on the Flow Blockchain with Dan Boney (Stanford University) and Dieter Shirley (Dapper Labs)The Flow Blockchain from CryptoKitties to NBA Top Shot [45:18]What is NBA Top Shot, and what was the hardest part of building it [50:34]Building a successful user experience [52:55]Negotiating with the NBA [54:32]The biggest challenges for NFTs going mainstream [56:55]Why did they build their own blockchain? [1:01:23]Building ERC-721 and lessons learned on crypto standards [1:04:00]Session 4: Going Beyond Collectibles and The Future of Tokens for Creators with Kevin Chou (Rally) and Chris Dixon (a16z)What are social tokens? (and how is Portugal. The Man. using them) [1:05:51]What are the roles of fungible and non-fungible tokens? [1:08:30]NFTs in gaming now and what's next [1:14:35]Pricing and price discovery for NFTs [1:17:39]Tips for launching a social token [1:19:06]How does Rally make money? [1:22:08]Session 5: NFT Use Cases Today and Tomorrow with Devin Finzer (OpenSea) and Katie Haun (a16z)What does OpenSea do? [1:26:14]Why the sudden interest in NFTs? [1:28:35]What can and can't be turned into an NFT [1:30:13]How NFTs can interact with the physical world [1:32:33]Virtual lands and the metaverse economy [1:35:14]Virtual concerts and NFT tickets [1:40:44]Mixing and remixing NFTs [1:43:04]Session 6: The Accidental Art DAO with pplpleasr (digital artist)pplpleasr's NFT "Apes Together Strong" that was auctioned as part of The NFT Summit serves as the artwork for this podcast.

19 Touko 20212h 1min

What inspired Eric and Sam to start Dyno [4:09]How does the use of ML impact Dyno's GTM [10:40]The current challenges of gene therapy [21:43]Why Dyno wants to be a horizontal platform for gene therapy [30:56]How does Dyno think about competition [44:23]After party and audience Q&A [52:01]It's Time to Heal, Mondays at 5pm PT on Clubhouse. Join the a16z bio team — Jorge Conde, Vineeta Argawala, Julie Yoo, and Vijay Pande — plus special guests every week as they explore all the ways that biology is technology.

18 Touko 20211h 14min

Note: the recording of this episode starts a minute or two into the show.Ali recommends: The Hard Thing about Hard Things  by Ben Horowitz [0:18]Ben recommends: High Output Management by Andy Grove [4:36]Marc recommends: Who Really Matters: The Core Group Theory of Power, Privilege, and Success by Art Kleiner [10:48]Best read for enterprise sales: Power Base Selling by Jim Holden, et al [13:06]Microsoft, Google, government contracts, and politicized workplaces [16:28]Marc recommends: The Tyranny of Structurelessness by Jo Freeman [29:32]Ali recommends: Radical Candor by Kim Scott [33:19]Ben recommends: No Rules Rules: Netflix and the Culture of Reinvention  by Erin Meyer and Reed Hastings [44:19]Ben recommends: Working Backwards: Insights, Stories, and Secrets from Inside Amazon by Colin Bryar [50:28]How they are approaching the return to work and remote work [53:00]Boss Talk is the Clubhouse show where a16z cofounder Ben Horowitz and Ali Ghodsi, the Founder/CEO of Databricks, discuss CEO stuff, leadership stuff, management stuff... boss stuff. Live every Tuesday 5-6pm on Clubhouse. For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse.

14 Touko 202159min