#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?
The Peter Attia Drive28 Tammi 2019

#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?

In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer's disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer's treatment and prevention.

We discuss:

  • Background and interest in the brain [5:15];
  • The unique nature of the human brain [9:15];
  • Why we've made so little progress in Alzheimer's research [23:00];
  • The amyloid beta hypothesis [28:30];
  • Hypometabolism in the brain leading to cognitive decline [39:30];
  • Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
  • The vascular hypothesis of Alzheimer's disease [54:00];
  • The relationship between mitochondria, cytochrome c oxidase, and Alzheimer's disease [1:08:00];
  • Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
  • Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
  • Methylene blue for treating and preventing neurodegeneration [1:38:15];
  • Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
  • Near infrared light as a targeted treatment for cognitive decline [2:05:30];
  • The ketogenic diet as a treatment and preventative measure [2:13:15];
  • Exciting future research coming from Francisco [2:23:00];
  • Methylene blue for traumatic brain injuries [2:25:15]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(459)

#410 ‒ The biology of pregnancy: physiologic adaptation, gestational diabetes, preeclampsia, childbirth, and long-term maternal health | Kathryn Gray, M.D., Ph.D.

#410 ‒ The biology of pregnancy: physiologic adaptation, gestational diabetes, preeclampsia, childbirth, and long-term maternal health | Kathryn Gray, M.D., Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter sits down with Dr. Kathryn (Katie) Gray, a ...

5 Loka 1h 57min

#409 ‒ Inside modern drug development: the science, economics, and regulatory hurdles behind bringing new medicines to patients | Lloyd Klickstein, M.D., Ph.D.

#409 ‒ Inside modern drug development: the science, economics, and regulatory hurdles behind bringing new medicines to patients | Lloyd Klickstein, M.D., Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Lloyd B. Klickstein is a physician-scientist who has spent more th...

28 Syys 2h 26min

#408 ‒ AMA #89: Thyroid health: interpreting symptoms, diagnosing and treating dysfunction, and navigating the gray zone

#408 ‒ AMA #89: Thyroid health: interpreting symptoms, diagnosing and treating dysfunction, and navigating the gray zone

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive i...

21 Syys 16min

#407 ‒ Preventing cardiovascular and Alzheimer's disease: lowering LDL early, APOE4, and promising new therapies | Michael Davidson, M.D.

#407 ‒ Preventing cardiovascular and Alzheimer's disease: lowering LDL early, APOE4, and promising new therapies | Michael Davidson, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Michael Davidson is a world-renowned cardiologist, lipidologist, a...

14 Syys 1h 59min

Blood pressure: how to measure, manage, and treat high blood pressure (AMA #48 rebroadcast)

Blood pressure: how to measure, manage, and treat high blood pressure (AMA #48 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter delves into the cri...

7 Syys 1h 16min

#406 ‒ Migraine, cluster headache, and tension headache: symptoms, causes, prevention, and treatment | Brian Grosberg, M.D.

#406 ‒ Migraine, cluster headache, and tension headache: symptoms, causes, prevention, and treatment | Brian Grosberg, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Grosberg is a world-renowned headache specialist who joins P...

31 Elo 1h 55min

#405 ‒ AMA #88: Metabolic liver health: how to assess risk, catch dysfunction early, and prevent or reverse liver disease

#405 ‒ AMA #88: Metabolic liver health: how to assess risk, catch dysfunction early, and prevent or reverse liver disease

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive i...

24 Elo 39min

#404 ‒ Mental health beyond neurotransmitters: the role of hormones in psychiatry, why symptom reduction isn't enough, and the future of psychedelic therapies | Linus Abrams, M.D.

#404 ‒ Mental health beyond neurotransmitters: the role of hormones in psychiatry, why symptom reduction isn't enough, and the future of psychedelic therapies | Linus Abrams, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter sits down with Dr. Linus Abrams, a psychiat...

17 Elo 2h 17min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
rss-pitaisko-erota
aamukahvilla
vakeva-elama-viisaampi-mieli-vahvempi-keho
psykopodiaa-podcast
meditaatiot-suomeksi
rss-kuumilla-aalloilla
voi-hyvin-meditaatiot-2
rss-uplevel-by-sonja-hannus
tiedenaiset-podcast
rss-pt-paahtio
rss-terapiaklubi
selviytyjat-tarinoita-elamasta
rss-mighty-finland-podcast
katilon-kahvitunti
paritellen
rss-narsisti
terapiassa
rss-sanelunpurku-podcast
rss-ehjaksi