246: SV2A structural pharmacology and allosteric occlusion
Pidathala S et al., Nature Communications - High-resolution cryo-EM structures of human SV2A reveal that orthosteric ligands induce an occluded MFS conformation and a secondary allosteric pocket modul...
1 Tammi 16min
245: Benchmarking DNA foundation models
Feng H et al., Nat Commun - A comprehensive, unbiased benchmark compares five DNA foundation models across 57 datasets and multiple tasks, finding mean token embeddings improve classification and that...
31 Joulu 202519min
244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis
Sun Z et al., Nature Communications - Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects...
30 Joulu 202517min
243: Genome-wide UVB GxE study finds 162 vitamin D variants
Shraim R et al., Nat Commun - A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified 307 independent loci for 25-hydroxyvitamin D, including...
29 Joulu 202517min
242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats
Godin P et al., Nature Communications - A single intramuscular injection of an AAV9 vector encoding feline anti‑Müllerian hormone (fcMISv2) in prepubertal kittens produced sustained supraphysiological...
28 Joulu 202517min
241: Wagyu T2T reveals a cattle X neocentromere
Pineda PS et al., Nature Communications - A telomere-to-telomere Wagyu assembly uncovers a natural neocentromere on the cattle X formed by inverted repeats and transposable element expansion, adds hun...
27 Joulu 202518min
240: CYFIP1 controls cortical axon development by modulating calcium
Ricci C et al., Nature Communications - Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function. Key terms: cyfip1, axon...
26 Joulu 202518min
239: Genomic Adaptations of the Svalbard Reindeer
Genome Biology and Evolution - The Genomic Basis of the Svalbard Reindeer’s Adaptation to an Extreme Arctic Environment Music:Enjoy the music based on this article at the end of the episode. Article...
25 Joulu 202519min
