190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D
Martínez‑López JA et al et al., Nature Communications - This episode examines a Nature Communications study that introduces differential Gene Coordination Network Analysis (dGCNA) applied to deep Smar...
6 Marras 202515min
189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how genome-wide DNA methylation profiling can p...
5 Marras 202514min
188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis
️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑scale mass‑spectrometry proteomics of cerebrospinal fl...
4 Marras 202516min
187: Gapped scheduling: CRLX101 + olaparib Phase I trial
Nature Communications (2025) 16:9457 et al., Nature Communications - Phase I dose-escalation trial combining CRLX101 (nanoparticle camptothecin) with olaparib using a 48-hour gapped schedule in 24 pat...
3 Marras 202516min
186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome
️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single‑cell RNA‑seq study of nasal biopsies showing that persist...
2 Marras 202515min
185: Altered Milk Tryptophan in Women Living with HIV
️ Episode 185: Altered Milk Tryptophan in Women Living with HIV In this episode of PaperCast Base by Base, we explore a longitudinal metabolomics study of human milk that reveals how maternal HIV inf...
1 Marras 202514min
184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification
️ Episode 184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification In this episode of PaperCast Base by Base, we explore a large-scale study that builds a risk factor–based XGBoost model...
31 Loka 202517min
183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences
️ Episode 183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences In this episode of PaperCast Base by Base, we explore a large causal study from Norway asking whet...
30 Loka 202518min
