54: Immune trajectories in COVID-19 among patients with end-stage kidney disease
Stephenson E et al., Cell Genomics - Longitudinal single-cell multi-omics profiling of PBMCs from 61 end-stage kidney disease (ESKD) patients with COVID-19 (580,040 cells) reveals distinct temporal im...
24 Kesä 202518min
53: Weighing PRS: costs, benefits, and evidence
Siena LM et al., The American Journal of Human Genetics - A systematic review of 24 full economic evaluations assessing polygenic risk score (PRS)–based clinical strategies across cancer, cardiovascul...
23 Kesä 202517min
52: LIZS6 methods and measurements
Keener R et al., Cell Genomics - A method-focused excerpt describing LIZS6-related experiments across multiple conditions (NoSk, LSFM) with quantitative readouts and protocol detail. Key terms: LIZS6,...
22 Kesä 202516min
51: Finding Hidden mtDNA Diagnoses in Solve-RD
Ratnaike et al et al., The American Journal of Human Genetics - This episode reviews a Solve-RD reanalysis that integrated an mtDNA-focused bioinformatic pipeline (MToolBox) with MitoPhen HPO-based ph...
21 Kesä 202517min
50: Translating the Microbiome to the Clinic
Porcari S et al., Cell - Perspective reviewing current diagnostic and therapeutic advances in gut microbiome research and outlining the methodological, biological, regulatory, and educational actions ...
19 Kesä 202517min
49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae
Holt JD et al., PNAS - Using microfluidic flow assays and live-cell imaging, the authors show that environmental DNA adsorbs to chitin particles and that Vibrio cholerae can retrieve this chitin-bound...
18 Kesä 202522min
48: Mainstreaming Clinical Genetic Testing: A Framework for Care
Mackley MP et al., Genetics in Medicine - A consensus-driven conceptual framework from Canadian genetics experts describing four models for mainstreaming clinical genetic testing and the variables tha...
16 Kesä 202516min
47: Encoding and decoding chemokine-GPCR selectivity
Kleist AB et al., Cell - A data-driven mapping of how 46 human chemokines and 23 GPCRs encode selective and promiscuous interactions. The team defines conserved, semi-conserved and variable determinan...
16 Kesä 202522min
