Orphan Drugs
99% Invisible14 Nov 2018

Orphan Drugs

We chronicle the epic struggle to get drugs that treat very rare diseases on the market, and the unintended consequence of that fight, which affected the cost of all kinds of drugs. This is a strange story that involves a hit 70s TV show, a fake march on Washington, a courageous advocate, a carnival concessions wholesaler, and a new drug law that helped a lot of people, made drug companies billions of dollars, and opened a whole can of worms.

Adapted from the new podcast An Arm and a Leg by Dan Weissmann

Orphan Drugs

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Longbox

Longbox

Reporter Whitney Jones argues that R.E.M.’s Out of Time is the most politically significant album in the history of the United States. Because of its packaging. Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

22 Juli 201416min

Snowflake

Snowflake

Well before the early 1500s, when Sir Thomas Moore first coined the term “Utopia,” people have been thinking about how to design their ideal community. Maybe it’s one that doesn’t use money, or one that drops traditional family structures and … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

15 Juli 201416min

Good Egress

Good Egress

When designing a commercial structure, there is one safety component that must be designed right into the building from the start: egress. “Egress” refers to an entire exit system from a building: stairs, corridors, and evacuation routes outside the building. Each state’s building … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

8 Juli 201415min

Cold War Kids

Cold War Kids

During the 1961 Berlin Crisis—one of the various moments in the cold war in which we came frighteningly close to engaging in actual war with the Soviets—President John F. Kennedy vowed to identify spaces in “existing structures both public and … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

1 Juli 201420min

Skyjacking

Skyjacking

The term “hijacking” goes back to prohibition days, when gangsters would rob moonshine trucks saying, “Hold your hands high, Jack!” However, in the early days of commercial air travel, the idea that someone would hijack a plane was scarcely even … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

24 Juni 201414min

Feet of Engineering

Feet of Engineering

As a fashion object and symbol, the high heel shoe is weighted with meaning. It’s also weighted with the wearer’s entire body weight. The stiletto might be one of the only designs that is physically painful but has somehow has … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

17 Juni 201414min

Song Exploder

Song Exploder

99% Invisible presents Song Exploder. A song is a product of design. It’s difficult to create an original melody, but that’s only the blueprint. Every element of a piece of music could be produced any number of ways, depending on which … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

10 Juni 201419min

Clean Trains

Clean Trains

In just about every movie set in New York City in the 1970s and 80s there’s an establishing shot with a graffiti-covered subway. For city officials, train graffiti was a sign that they had lost control. So, starting in the … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

3 Juni 201419min

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