Overdose risk, opioid agonists and other medications with Eleni Domzaridou

Rob Calder talks to Dr Eleni Domzaridou about her recent article on the risk of overdose among people prescribe medication for opioid use at the same time as being prescribed other medication - such as for mental health disorders.

People who use opioid drugs are often prescribed drugs for physical or mental health problems or for pain management. Eleni and the research team studied non-fatal overdoses among this group of people. In this podcast, Eleni outlines why the marker of non-fatal overdose is important when seeking to prevent fatal overdoses. Eleni also talks about the challenges and practicalities of using a large data-set with data from GP surgeries to draw conclusions about associations between prescribed drug use and overdoses.

There is an elevated non-fatal overdose risk for patients prescribed opioid agonists concurrently with benzodiazepines, gabapentinoids, z-drugs or antipsychotics.

Original article: Non-fatal overdose risk associated with prescribing opioid agonists concurrently with other medication: cohort study conducted using linked primary care, secondary care, and mortality records by Eleni Domzaridou and colleagues. Published in Addiction (2023)

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