Carnivore
2 Keto Dudes12 Dec 2016

Carnivore

Carl Franklin and Richard Morris talk to Amber O'Hearn about being a carnivore, evolution, sleep, ketogenic metabolism, and a few other tasty nuggets you won't want to miss! Errata Richard forgot to mention when working with Transglutaminase .. wear food prep gloves. Amber sent us a piece of errata. She writes: In our podcast, Carl asks me if babies *have* to be in ketosis to build brains, and I say yes, but that's not true. That is, the primary way that babies build fat and cholesterol in the brain in normal conditions *is* out of ketone bodies, though a small proportion is also made from glucose. I have a few references on this point in the talk transcript on my blog. The critical question is: What happens if there are no ketones to be had and only glucose? The answer seems to be that glucose will suffice. There is a rare inborn error of metabolism called HMG-CoA lyase deficiency, which prevents the body from making ketones. A paper by another brilliant Morris ( Cerebral ketone body metabolism ) reports that people afflicted with this have white matter abnormalities, but no noticeable loss of function, except of course, they can't go without food for long. This suggests that in cases where there are no circulating ketones, the glucose alternative pathway will take over, and get at least an adequate brain constructed. It occurs to me that children with this condition may be perfect candidates for the therapeutic use of ketones esters, provided the condition doesn't somehow prevent their use. "Given the importance of KBs [ketone bodies] as substrates for myelination, one might expect disorders of ketogenesis to be associated with cerebral white-matter abnormalities. Magnetic resonance imaging has, indeed, shown diffuse mildly increased signal in the white matter of patients with HMG-CoA lyase deficiency. Superimposed on this are foci of more abnormal signal. In most cases, multiple lesions have been present, varying in size from a few millimetres to large confluent areas; as well as in the cerebral hemispheres, they have been reported in the internal capsule and brainstem but not in the corpus callosum or cerebellar white matter. Despite the imaging abnormalities, most patients have had no neurological problems and normal or slightly below average intelligence. The findings would be compatible with hypomyelination, caused by the lack of KB." Support this podcast at — https://redcircle.com/2-keto-dudes/donations

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Protein

Protein

Today Richard and Carl geek out on Protein. So much of what they do is separating fact from fiction, and this episode is no different. Did you know that excess protein turns into glucose? Of course, there is science to back all of this up. Good thing the dudes have learned to harness their OCD for the powers of good! Eratta: Carl mentioned that sugars like glucose and fructose trigger an insulin response but only glucose does. Fructose doesn't require insulin to be metabolized. Richard mentioned that after 6 months of keto he was left with "massive" muscles, this is in relation to the muscles he thought he totally didn't have before he started keto. Support this podcast at — https://redcircle.com/2-keto-dudes/donations

19 Mars 201649min

Fasting

Fasting

Richard and Carl talk about their experiences with fasting. You should always consult your doctor before starting a fast. That said, both Carl and Richard had great experiences with fasting. It's not what you think. It's much better. Eratta Richard mentioned that his regular glucose is 5.2 mmol/l and incorrectly converted that to 80 mg/dl which is incorrect. 5.2 mmol/l is actually 93 mg/dl. There is an online tool for converting between mmol/l and mg/dl at http://en.mte.cz/conversion.php Support this podcast at — https://redcircle.com/2-keto-dudes/donations

14 Mars 201644min

The Big Fat Show

The Big Fat Show

This week Carl and Richard talk about fat. Good fats. Bad fats. Fat myths and fat facts. They also talk about Post Induction Stall Syndrome, an expected pause in weight loss that happens around week 2 or 3, and can last for up to 6 weeks. Recipes this week include Carl's Fathead pizza and Richard's pulled lamb shoulder. Errata Richard stated that Almond is high in Omega 6 PUFAs but it is only 12% PUFA and 30% MUFA. If you eat a lot it will contribute a fair amount of OMega 6 PUFAs to your diet, but in small amount it won't likely be a problem. Macadamia Oil however has less than 1% PUFA and 61% MUFA so there really is no reason to not use Macadamia oil. Support this podcast at — https://redcircle.com/2-keto-dudes/donations

7 Mars 201645min

Insulin

Insulin

This week Carl and Richard talk about insulin - the quarterback of hormones, and one that they have both been producing at champion rates until the moment we went keto. They also talk about salt, minerals, glycogen, inflammation, cardiovascular disease, and the various aspects of metabolic syndrome. Recipes this week include Richards Brown Chicken Stock and Carl's Keto-Waffles. Errata Richard misspoke about the study of the Scotsman who hold the Guinness world book of records for the longest fast. He actually fasted for 382 days, not 250 days. Support this podcast at — https://redcircle.com/2-keto-dudes/donations

29 Feb 201643min

Sugar

Sugar

Why is sugar so toxic? Is there a difference between how glucose and fructose get metabolized? Carl and Richard answer these and other important questions about sugar on this episode of 2 Keto Dudes. Recipes this week include Pad Thai Chicken from Carl and the Maple Bacon Ice cream from Richard. Errata Richard mistakenly referred to the ancient greeks discovering that Diabetes is related to sugar by tasting it .... actually that's not true. In 1674, it was English physician Thomas Willis discovered that the urine of a diabetic Patient was "wonderfully sweet as if imbued with Honey". The ancient greeks however first noticed that people who had diabetes had insatiable thirst and peed all the time - so the name diabetes is greek for "Siphon". They have a sense of humor those ancient greeks. Richard said (11:25) that "Lustig says ... that fructose causes insulin sensitivity" ... but of course he intended to say "fructose causes the insulin resistance that ultimately makes glucose an acute poison" Support this podcast at — https://redcircle.com/2-keto-dudes/donations

22 Feb 201637min

Getting Started. Keto Flu

Getting Started. Keto Flu

In the premiere episode of 2 Keto Guys Carl and Richard bring you up to speed on the science and common sense behind the ketogenic diet. Errata Richard mistakenly referred to the Heart being 22% more efficient when running on ketones at 18:07 - the correct figure is a 28% better hydraulic efficiency (per: The therapeutic implications of ketone bodies). Support this podcast at — https://redcircle.com/2-keto-dudes/donations

15 Feb 201644min

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