#104 – Pardis Sabeti on the Sentinel system for detecting and stopping pandemics

#104 – Pardis Sabeti on the Sentinel system for detecting and stopping pandemics

When the first person with COVID-19 went to see a doctor in Wuhan, nobody could tell that it wasn’t a familiar disease like the flu — that we were dealing with something new.

How much death and destruction could we have avoided if we'd had a hero who could? That's what the last Assistant Secretary of Defense Andy Weber asked on the show back in March.

Today’s guest Pardis Sabeti is a professor at Harvard, fought Ebola on the ground in Africa during the 2014 outbreak, runs her own lab, co-founded a company that produces next-level testing, and is even the lead singer of a rock band. If anyone is going to be that hero in the next pandemic — it just might be her.

Links to learn more, summary and full transcript.

She is a co-author of the SENTINEL proposal, a practical system for detecting new diseases quickly, using an escalating series of three novel diagnostic techniques.

The first method, called SHERLOCK, uses CRISPR gene editing to detect familiar viruses in a simple, inexpensive filter paper test, using non-invasive samples.

If SHERLOCK draws a blank, we escalate to the second step, CARMEN, an advanced version of SHERLOCK that uses microfluidics and CRISPR to simultaneously detect hundreds of viruses and viral strains. More expensive, but far more comprehensive.

If neither SHERLOCK nor CARMEN detects a known pathogen, it's time to pull out the big gun: metagenomic sequencing. More expensive still, but sequencing all the DNA in a patient sample lets you identify and track every virus — known and unknown — in a sample.

If Pardis and her team succeeds, our future pandemic potential patient zero may:

1. Go to the hospital with flu-like symptoms, and immediately be tested using SHERLOCK — which will come back negative
2. Take the CARMEN test for a much broader range of illnesses — which will also come back negative
3. Their sample will be sent for metagenomic sequencing, which will reveal that they're carrying a new virus we'll have to contend with
4. At all levels, information will be recorded in a cloud-based data system that shares data in real time; the hospital will be alerted and told to quarantine the patient
5. The world will be able to react weeks — or even months — faster, potentially saving millions of lives

It's a wonderful vision, and one humanity is ready to test out. But there are all sorts of practical questions, such as:

• How do you scale these technologies, including to remote and rural areas?
• Will doctors everywhere be able to operate them?
• Who will pay for it?
• How do you maintain the public’s trust and protect against misuse of sequencing data?
• How do you avoid drowning in the data the system produces?

In this conversation Pardis and Rob address all those questions, as well as:

• Pardis’ history with trying to control emerging contagious diseases
• The potential of mRNA vaccines
• Other emerging technologies
• How to best educate people about pandemics
• The pros and cons of gain-of-function research
• Turning mistakes into exercises you can learn from
• Overcoming enormous life challenges
• Why it’s so important to work with people you can laugh with
• And much more

Chapters:

  • The interview begins (00:01:40)
  • Trying to control emerging contagious diseases (00:04:36)
  • SENTINEL (00:15:31)
  • SHERLOCK (00:25:09)
  • CARMEN (00:36:32)
  • Metagenomic sequencing (00:51:53)
  • How useful these technologies could be (01:02:35)
  • How this technology could apply to the US (01:06:41)
  • Failure modes for this technology (01:18:34)
  • Funding (01:27:06)
  • mRNA vaccines (01:31:14)
  • Other emerging technologies (01:34:45)
  • Operation Outbreak (01:41:07)
  • COVID (01:49:16)
  • Gain-of-function research (01:57:34)
  • Career advice (02:01:47)
  • Overcoming big challenges (02:10:23)

Producer: Keiran Harris.
Audio mastering: Ben Cordell.
Transcriptions: Sofia Davis-Fogel.

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#3 - Dario Amodei on OpenAI and how AI will change the world for good and ill

#3 - Dario Amodei on OpenAI and how AI will change the world for good and ill

Just two years ago OpenAI didn’t exist. It’s now among the most elite groups of machine learning researchers. They’re trying to make an AI that’s smarter than humans and have $1b at their disposal. Even stranger for a Silicon Valley start-up, it’s not a business, but rather a non-profit founded by Elon Musk and Sam Altman among others, to ensure the benefits of AI are distributed broadly to all of society.  I did a long interview with one of its first machine learning researchers, Dr Dario Amodei, to learn about: * OpenAI’s latest plans and research progress. * His paper *Concrete Problems in AI Safety*, which outlines five specific ways machine learning algorithms can act in dangerous ways their designers don’t intend - something OpenAI has to work to avoid. * How listeners can best go about pursuing a career in machine learning and AI development themselves. Full transcript, apply for personalised coaching to work on AI safety, see what questions are asked when, and read extra resources to learn more. 1m33s - What OpenAI is doing, Dario’s research and why AI is important  13m - Why OpenAI scaled back its Universe project  15m50s - Why AI could be dangerous  24m20s - Would smarter than human AI solve most of the world’s problems?  29m - Paper on five concrete problems in AI safety  43m48s - Has OpenAI made progress?  49m30s - What this back flipping noodle can teach you about AI safety  55m30s - How someone can pursue a career in AI safety and get a job at OpenAI  1h02m30s - Where and what should people study?  1h4m15s - What other paradigms for AI are there?  1h7m55s - How do you go from studying to getting a job? What places are there to work?  1h13m30s - If there's a 17-year-old listening here what should they start reading first?  1h19m - Is this a good way to develop your broader career options? Is it a safe move?  1h21m10s - What if you’re older and haven’t studied machine learning? How do you break in?  1h24m - What about doing this work in academia?  1h26m50s - Is the work frustrating because solutions may not exist?  1h31m35s - How do we prevent a dangerous arms race?  1h36m30s - Final remarks on how to get into doing useful work in machine learning

21 Juli 20171h 38min

#2 - David Spiegelhalter on risk, stats and improving understanding of science

#2 - David Spiegelhalter on risk, stats and improving understanding of science

Recorded in 2015 by Robert Wiblin with colleague Jess Whittlestone at the Centre for Effective Altruism, and recovered from the dusty 80,000 Hours archives. David Spiegelhalter is a statistician at the University of Cambridge and something of an academic celebrity in the UK. Part of his role is to improve the public understanding of risk - especially everyday risks we face like getting cancer or dying in a car crash. As a result he’s regularly in the media explaining numbers in the news, trying to assist both ordinary people and politicians focus on the important risks we face, and avoid being distracted by flashy risks that don’t actually have much impact. Summary, full transcript and extra links to learn more. To help make sense of the uncertainties we face in life he has had to invent concepts like the microlife, or a 30-minute change in life expectancy. (https://en.wikipedia.org/wiki/Microlife) We wanted to learn whether he thought a lifetime of work communicating science had actually had much impact on the world, and what advice he might have for people planning their careers today.

21 Juni 201733min

#1 - Miles Brundage on the world's desperate need for AI strategists and policy experts

#1 - Miles Brundage on the world's desperate need for AI strategists and policy experts

Robert Wiblin, Director of Research at 80,000 Hours speaks with Miles Brundage, research fellow at the University of Oxford's Future of Humanity Institute. Miles studies the social implications surrounding the development of new technologies and has a particular interest in artificial general intelligence, that is, an AI system that could do most or all of the tasks humans could do. This interview complements our profile of the importance of positively shaping artificial intelligence and our guide to careers in AI policy and strategy Full transcript, apply for personalised coaching to work on AI strategy, see what questions are asked when, and read extra resources to learn more.

5 Juni 201755min

#0 – Introducing the 80,000 Hours Podcast

#0 – Introducing the 80,000 Hours Podcast

80,000 Hours is a non-profit that provides research and other support to help people switch into careers that effectively tackle the world's most pressing problems. This podcast is just one of many things we offer, the others of which you can find at 80000hours.org. Since 2017 this show has been putting out interviews about the world's most pressing problems and how to solve them — which some people enjoy because they love to learn about important things, and others are using to figure out what they want to do with their careers or with their charitable giving. If you haven't yet spent a lot of time with 80,000 Hours or our general style of thinking, called effective altruism, it's probably really helpful to first go through the episodes that set the scene, explain our overall perspective on things, and generally offer all the background information you need to get the most out of the episodes we're making now. That's why we've made a new feed with ten carefully selected episodes from the show's archives, called 'Effective Altruism: An Introduction'. You can find it by searching for 'Effective Altruism' in your podcasting app or at 80000hours.org/intro. Or, if you’d rather listen on this feed, here are the ten episodes we recommend you listen to first: • #21 – Holden Karnofsky on the world's most intellectual foundation and how philanthropy can have maximum impact by taking big risks • #6 – Toby Ord on why the long-term future of humanity matters more than anything else and what we should do about it • #17 – Will MacAskill on why our descendants might view us as moral monsters • #39 – Spencer Greenberg on the scientific approach to updating your beliefs when you get new evidence • #44 – Paul Christiano on developing real solutions to the 'AI alignment problem' • #60 – What Professor Tetlock learned from 40 years studying how to predict the future • #46 – Hilary Greaves on moral cluelessness, population ethics and tackling global issues in academia • #71 – Benjamin Todd on the key ideas of 80,000 Hours • #50 – Dave Denkenberger on how we might feed all 8 billion people through a nuclear winter • 80,000 Hours Team chat #3 – Koehler and Todd on the core idea of effective altruism and how to argue for it

1 Maj 20173min

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