Journal Club: Slaying the Sleeper Cells of Aging with CAR T

India and China. The two most populous countries on the planet are also two of the most tantalizing markets for companies of all size, from startups to conglomerates. But those markets are also intensely, densely competitive: There's a lot of capital, a lot of players, and a whole lot of people. So do local players really have the home-court advantage here? Can they compete with the global players who have unparalleled execution ability and scale? And how does timing and structuring of companies entering those markets matter? Andreessen Horowitz partners Connie Chan and Anu Hariharan discuss these topics and more -- everything from logistics and infrastructure to design and talent -- on this episode of the a16z Podcast. As well as how domains like e-commerce, payments, and ride-sharing are playing out against the incredibly layered sociocultural backdrop of these two countries.

12 Dec 201545min

Our final segment from the road in the U.K. features two well-known investors and entrepreneurs in the London tech world: Seedcamp co-founder Reshma Sahoni and Shakil Khan (known to all simply as Shak), the founder of CoinDesk and an early investor in Spotify where he also headed up special projects. Reshma and Shak break down the venture scene in London, and describe the particular way the best companies scale in Europe ... it's not what you are probably thinking. Finally, they brag about some European startups we should all be paying attention to. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

4 Dec 201534min

What if you could bring the best version of yourself to everything you do everyday? What if you could get the most out of your mind and brain -- or more scientifically, your "cognitive performance" -- without going to those old addictive standbys like coffee or RedBulls? The promise of nootropics or cognitive enhancers is to help us work better and more productively (for example, through more stamina and working memory); stay more awake and alert (without the sudden jolt of coffee); sleep better; and even protect our brains against cognitive impairments or neuro diseases like Alzheimer's. Geoffrey Woo and Michael Brandt, the founders of Nootrobox, believe that nootropics are possible for everyone -- not just for a select or hobbyist fringe of society -- and that part of that mainstreaming will involve a lot of hard science, hard data, and frankly, good user experience and better packaging of raw components ... the same things, in fact, that helped mainstream personal computers from the days of the early hacking at the Homebrew Club to Apple and the world of mass computing today. But how does nootropics move beyond a community movement ... and how does it fit into the context of other trends such as biohacking, quantified self, and more? Is the human body really the next 'platform'? All this and more on this episode of the a16z Podcast. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

4 Dec 201523min

The pod continues its U.K. road trip, meeting up with three startup founders -- including one startup accelerator programme -- to discuss the entrepreneurial ecosystem in London and more broadly the U.K. and Europe. Let’s be clear upfront: London is not the center of the universe when it comes to technology. But the diversity of industries and thinking in the British capital brings with it advantages when starting a tech company, say our guests on this segment of the podcast, which includes Michelle You, co-founder of Songkick; co-founder of Lifecake, and former Skype engineer Nick Babaian; and Matt Clifford, co-founder of London-based accelerator Entrepreneur First. So what does it take to build flourishing startup communities?

1 Dec 201533min

Brett Hagler was on a trip to Haiti after the 2010 earthquake where he saw too many of those displaced by the natural disaster still living in tattered blue-tarp shelters. What struck Hagler was the need for more permanent housing that could not only offer much needed safety for families, but help foster the community that was split apart following the earthquake. The non-profit startup NewStory is Hagler’s answer to that need. NewStory co-founder Alexandria Lafci joins Hagler on this segment of the a16z Podcast to discuss the startup’s social-media powered approach to giving -- and why even as a non-profit startup they think and act like any other for-profit tech startup looking to make a mark.

28 Nov 201525min

The best cooks know cooking a meal is all about having a plan (and a back-up plan if things go south); get the cooking out of the way, and then you can enjoy your family and friends -- the most important part. But now try doing it for thousands. How can one company be the de facto sous chef for so many? Turns out there's a lot of data science behind it, in everything from procurement to forecasts to logistics: what to cook, what people will like, what ingredients are required, what to produce at scale. In this segment of the a16z Podcast, Gobble's Ooshma Garg suggests that every modern food company is really a tech company (or should be). Is there a science to taste? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

25 Nov 201519min

Farmers are among the best hackers in the business. They can fix anything, and are endlessly tweaking their approach to a business that is up against the strongest force on the planet: nature. As adopters of technology, the agriculture industry is both forward-thinking and, at the same time, hard to convince to make a change. For good reason -- you can’t A/B-test an almond orchard. You get one shot a year to grow a crop and make a profit. So whatever technology makes its way into the fields had better work. U.C. Santa Barbara computer science professor Chandra Krintz, Granular CEO and co-founder Sid Gorham, and Fruition Sciences co-founder Thibaut Scholasch join this segment of the a16z Podcast to discuss technologies working down on the farm. Including how sensors monitoring soil elements, water flow in plants, and fertilizer schedules are yielding fruitful data. Given the high stakes -- a planet in the midst of climate change -- what we can all learn from how technology is accepted and implemented in the agriculture industry? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

24 Nov 201530min

Rob Rhinehart, like most startup entrepreneurs, was strapped for cash and time as developed his ideas and ultimately a company. What stood out to Rhinehart in that all-consuming and ongoing process was the contrast between all the things in his life that technology had made more convenient and cheaper -- basically everything powered by smartphones -- and what he felt was a process still trapped in our agrarian past: sitting down for a meal. Out of that observation came Soylent -- nutrition in powder or ready-to-drink form, that substituted for Rhinehart the lousy ramen or frozen corn-dog meals he was subsisting on. Better, faster, cheaper -- Soylent has all the trademarks of good tech -- but are we really going to start drinking our meals? Rhinehart joins this segment of the pod along with a16z’s Chris Dixon, who led the firm’s investment in Soylent, to talk about where Soylent might fit into our lives ... and what it means for the future of food as well as earth's resources. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

24 Nov 201532min