Degrading Drugs for Problem Proteins: Journal Club now on Bio Eats World (ep 2)

The Google I/O keynote was epic in at least one respect, length. For three hours Google laid out the near horizon for all things Google. This included the next version of Android; a new platform for connected watches; Google for your car; yet another Google TV; and a new health platform. Andreessen Horowitz’s Benedict Evans plowed through it all, including what was noticeably absent: Google+ and Google Glass. What the future looks like as the lines between mobile apps and web pages blur, and why Google is the new Microsoft -- in the best possible way.

26 Juni 201433min

The datacenter has long been -- there's no nice way to put this -- a bit of a snoozer. Expensive boxes running expensive software. No more, says a16z General Partner Peter Levine. Along with Chris Dixon, Levine lays out a vision for the datacenter of the future. Building on the technology established by companies like Facebook and Google, Levine and Dixon describe a software-led transformation of the datacenter, one where the mobile supply chain and fast-moving companies are reimagining everything -- from the underlying architecture to new business models. Be prepared to get in the weeds, hear Levine talk about the next opportunity, “hosted instances,” Dixon describe the “the dream within the dream,” and discover why the datacenter is about to get exciting.

18 Juni 201425min

People Marketplaces are a lot like eBay -- connecting buyer and seller -- but for services, says a16z General Partner Jeff Jordan. These two-sided marketplaces are cropping up across the economy, from finding a ride to house cleaning and pet sitting. Now Instacart is bringing the People Marketplace model to the grocery business -- a massive market that has seen very little change even as the internet and mobile have upended most retail categories. Joined by a16z's Sam Gerstenzang, this segment outlines the elements of a People Marketplace; why the model is gathering momentum now; and if we all remember what happened with Webvan, why is this time is different?

16 Juni 201412min

a16z Board Partner Steven Sinofsky and Box CEO and co-founder Aaron Levie discuss findings from a study of the information economy that has been built on cloud and mobile. The findings were based on workflow data collected anonymously from a subset of 25 million users, 225,000 businesses, and five industries (you can see the report here: http://blog.box.com/2014/06/mapping-the-information-economy-a-tale-of-five-industries/). It all amounts to big shifts in enterprise IT. But what are the implications of these findings for everyone’s business ... beyond Silicon Valley and the software industry? And finally -- shared in a live brainstorm at the end -- what’s the future of the cloud?

13 Juni 201417min

The announcement by Apple of its new programming language Swift is prompting developers to consider yet again how to tailor their efforts in the battle between iOS and Android. Benedict Evans and Steven Sinofsky discuss the questionable history of cross-platform software, and strategies for startups building apps today. How developers can build great apps on both of the largest mobile platforms. This platform question is one Sinofsky has been grappling with for a very long time, and which he also details in this post: http://blog.learningbyshipping.com/2013/07/08/juggling-multiple-platforms-and-the-bumpy-road-ahead/

6 Juni 201416min

Benedict Evans is a veteran of Apple’s big events and puts all the announcements and demos into one of three categories: 1) all the cool incremental improvements to the Apple operating systems; 2) the tent-pole features that Apple likes to build marketing campaigns around; 3) and finally, the fundamental strategic moves by Apple that serve to push the company ahead of the competition. With help from Andreessen Horowitz technical talent partner Dave Jagoda, this segment picks apart all three categories.

3 Juni 201423min

For Jim Gilliam, the founder of NationBuilder, community is everything. When he needed a double lung transplant, Gilliam turned to the Internet and to his online community to make it happen. He's organized political campaigns, made documentary films, and built his company NationBuilder by tapping into the power that large scale communities on the internet provide. Community at internet scale is a deep reservoir of people, ideas and yes, money, that Gilliam believes changes how we do almost everything - and makes almost anything possible.

30 Maj 20149min

Optimizely is a superb example of the democratization of software development. You don't need an engineering degree to fire up Optimizely and start testing how design changes on your website -- down to the pixel level -- affect things like time on site, closing sales, navigation, etc. The a/b testing Optimizely offers is just one example of a new wave of tools born of the internet, and designed for how people work, shop, research and entertain themselves online. Andreessen Horowitz's Scott Weiss, who is taking a seat on the Optimizely board following a16z's recent investment, a16z Partner Tom Rikert, and Optimizely co-founder Dan Siroker discuss the next wave of internet tools, where entrepreneurs are headed next, and how virtually anyone can avail themselves of this technical brawn.

20 Maj 201420min