Degrading Drugs for Problem Proteins: Journal Club now on Bio Eats World (ep 2)

Google, eBay, even the Web itself, in the beginning all of these things appeared as point products, interesting in their way, but small. Of course, they weren’t. “There is this swallow-the-red-pill moment that happens,” Marc Andreessen says, “Where you realize something really, really big is going to happen.” Optimization -- the relentless improvement of everything -- is another one of those ideas. In this segment of the pod, Andreessen joins Optimizely CEO Dan Siroker during the company’s annual conference Opticon for a conversation that covers a huge swath of what’s most exciting in tech today: the spread of optimization tools, privacy trends, artificial intelligence, virtual reality, Bitcoin, and killer robots. All that, and why Donald Trump’s hair could use some A/B testing. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

20 Aug 201549min

How do you face down cancer? Get told you can’t get life-saving organ transplants, and go about getting them anyway? And in the middle of that mental and physical storm, how do you find the thing that you and only you were meant to do -- and start building it? One person with answers is Jim Gilliam, the founder of NationBuilder, because that is what he had to do -- all of it. It’s given Gilliam a clear philosophy on life, and on being a leader. And what he’s learned along the way, he says, is something everyone can tap into. Gilliam first told his story in a break-the-Internet video, “The Internet is My Religion,” he’s gone deeper with his recently published book of the same title. a16z's Ben Horowitz sat down with Gilliam on the occasion of his book launch, to hear more about his philosophy on life, religion, leadership and what we all can do to move this world forward. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

18 Aug 201523min

As more and more of what we do for fun and work- happens online, establishing identity becomes ever more critical. Whether it’s for dating or sending money, you want to trust that not only are you interacting with the person you think you are, but that your messages (or money) are in fact reaching the right person -- and only them. Sounds simple, but with an internet and computers in between, a lot can go wrong -- whether by accident or malicious design. A16z’s Chris Dixon, and Max Krohn, co-founder of the encryption startup Keybase, examine the problem in this segment of the pod. What makes cryptography so hard to use, what approach Krohn and the Keybase team are taking, and why crypto “key parties” are not what you might think. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

17 Aug 201521min

This special episode of the a16z Podcast is based on a Q&A from an early screening we hosted of Universal Pictures’ Straight Outta Compton, the story of the group N.W.A. that revolutionized music and pop culture. The Q&A features Ice Cube, producer, rapper, and one of the original members of N.W.A.; director F. Gary Gray; and Corey Hawkins, Jason Mitchell, and O’Shea Jackson Jr., who play Dr. Dre, Eazy-E, and Ice Cube, respectively. Their wide-ranging conversation -- as interviewed by a16z's Ben Horowitz -- covers the struggle, the drive, the creative process, the cycles of history, the city of Los Angeles ... and why “it’s cool to be a nerd”. photo credit: Khristopher 'Squint' Sandifer

15 Aug 201546min

When you're going for a board interview -- especially when it's your first board seat -- you're actually not supposed to go into it advocating for yourself and trying to convince people that you're a good operator, as you might in a job interview. So what does the board interview involve then? Is all the common advice we hear about getting on boards (e.g., "don't talk about strategy") really true? TaskRabbit COO Stacy Brown-Philpot, who was just announced to the HP Inc board (in Hewlett Packard's first major board shuffle since it split into two companies), answers these questions and shares other interesting nuggets from her experience getting her first board seat. She also shares why she went for a public board, as well as what other factors you should consider -- and really matter -- when considering board service. Joining her is Matt Levy, who manages a16z's board and mentor talent network as part of the executive talent team. For more resources on boards, see http://a16z.com/tag/board-matters-series/.

13 Aug 201520min

There's been a lot of activity lately around trying to improve equity compensation (for example, by removing tax liabilities that handcuff them). Or by making equity more equitable in other ways; as former Groupon CEO Andrew Mason observed, "When startups grow into unicorns, the distribution of employee earnings follows a common pattern: the founders make more money than they could spend in infinite lifetimes, a handful of early folks achieve financial independence, and everyone else gets a nice bonus, but nothing life changing." It's admittedly a very rarefied problem yet one that plagues a number of startup founders and employees who put in a lot of work to make the startup a success ... but end up with less than others in the same company. And it's a problem that has long plagued Mason, who shared his views on something he calls "progressive equity" to help more startup employees achieve financial independence if and when their companies exit through an IPO, acquisition, or other liquidity event. Can it work? Should it? a16z General Partner and co-founder Ben Horowitz joins Mason on this episode of the a16z Podcast to dissect the idea. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

7 Aug 201523min

The key to any great company is the people. Of course, part of attracting and keeping the best people is compensation. It seems straightforward, but if you don’t develop a philosophy early around how you are going to compensate all those great employees you’re going to be in a world of hurt later, says Shannon Schiltz, who heads up a16z’s People Practice. Compensation, from salary to different forms of equity, is the topic of this segment of the a16z Podcast. For the founders of many fast-growing companies it’s often an afterthought, says the other compensation expert on the pod, Than Nguyen. Founders are busy enough just finding enough people to build and grow their startup. But as a founder you need to raise your head up and consider how compensation fits into your long-term plans. Nguyen and Shiltz discuss ways to make that happen.

7 Aug 201531min

There are few things as old as financial catastrophe, except maybe finance. But in the latest fiscal meltdown in Greece, people started asking questions about whether newer technology -- bitcoin and the underlying blockchain -- could help. One of those was Wall Street Journal columnist Christopher Mims. In this episode of the pod, Mims and Coinbase CEO and co-founder Brian Armstrong talk about the current state and future possibility of bitcoin and the bitcoin blockchain. When it comes to Greece -- or the next financial snafu -- Armstrong and Mims think there is potential for bitcoin to help, but some education and UI mainstreaming needs to happen first. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

7 Aug 201534min