Man, Mosquito, Malaria Vaccine
a16z Podcast2 Maj 2021

Man, Mosquito, Malaria Vaccine

Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five.

So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- Rajeev Venkayya of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and what's left to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease?

Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been nearly a century in the making.

Avsnitt(900)

a16z Podcast: Datacenter of the Future

a16z Podcast: Datacenter of the Future

The datacenter has long been -- there's no nice way to put this -- a bit of a snoozer. Expensive boxes running expensive software. No more, says a16z General Partner Peter Levine. Along with Chris Dixon, Levine lays out a vision for the datacenter of the future. Building on the technology established by companies like Facebook and Google, Levine and Dixon describe a software-led transformation of the datacenter, one where the mobile supply chain and fast-moving companies are reimagining everything -- from the underlying architecture to new business models. Be prepared to get in the weeds, hear Levine talk about the next opportunity, “hosted instances,” Dixon describe the “the dream within the dream,” and discover why the datacenter is about to get exciting.

18 Juni 201425min

a16zPodcast: People Marketplaces Take On One of the Last Great E-Commerce Opportunities -- Groceries

a16zPodcast: People Marketplaces Take On One of the Last Great E-Commerce Opportunities -- Groceries

People Marketplaces are a lot like eBay -- connecting buyer and seller -- but for services, says a16z General Partner Jeff Jordan. These two-sided marketplaces are cropping up across the economy, from finding a ride to house cleaning and pet sitting. Now Instacart is bringing the People Marketplace model to the grocery business -- a massive market that has seen very little change even as the internet and mobile have upended most retail categories. Joined by a16z's Sam Gerstenzang, this segment outlines the elements of a People Marketplace; why the model is gathering momentum now; and if we all remember what happened with Webvan, why is this time is different?

16 Juni 201412min

a16z Podcast: Mapping the Information Economy -- Where’s the Cloud Going Next?

a16z Podcast: Mapping the Information Economy -- Where’s the Cloud Going Next?

a16z Board Partner Steven Sinofsky and Box CEO and co-founder Aaron Levie discuss findings from a study of the information economy that has been built on cloud and mobile. The findings were based on workflow data collected anonymously from a subset of 25 million users, 225,000 businesses, and five industries (you can see the report here: http://blog.box.com/2014/06/mapping-the-information-economy-a-tale-of-five-industries/). It all amounts to big shifts in enterprise IT. But what are the implications of these findings for everyone’s business ... beyond Silicon Valley and the software industry? And finally -- shared in a live brainstorm at the end -- what’s the future of the cloud?

13 Juni 201417min

a16z Podcast: The Promise (and Nightmare) of Cross-Platform Software

a16z Podcast: The Promise (and Nightmare) of Cross-Platform Software

The announcement by Apple of its new programming language Swift is prompting developers to consider yet again how to tailor their efforts in the battle between iOS and Android. Benedict Evans and Steven Sinofsky discuss the questionable history of cross-platform software, and strategies for startups building apps today. How developers can build great apps on both of the largest mobile platforms. This platform question is one Sinofsky has been grappling with for a very long time, and which he also details in this post: http://blog.learningbyshipping.com/2013/07/08/juggling-multiple-platforms-and-the-bumpy-road-ahead/

6 Juni 201416min

a16z Podcast: The Apple WWDC 2014 Deep Dive

a16z Podcast: The Apple WWDC 2014 Deep Dive

Benedict Evans is a veteran of Apple’s big events and puts all the announcements and demos into one of three categories: 1) all the cool incremental improvements to the Apple operating systems; 2) the tent-pole features that Apple likes to build marketing campaigns around; 3) and finally, the fundamental strategic moves by Apple that serve to push the company ahead of the competition. With help from Andreessen Horowitz technical talent partner Dave Jagoda, this segment picks apart all three categories.

3 Juni 201423min

a16z Podcast: You Just Thought You Were Building a Software Company. It's a Community.

a16z Podcast: You Just Thought You Were Building a Software Company. It's a Community.

For Jim Gilliam, the founder of NationBuilder, community is everything. When he needed a double lung transplant, Gilliam turned to the Internet and to his online community to make it happen. He's organized political campaigns, made documentary films, and built his company NationBuilder by tapping into the power that large scale communities on the internet provide. Community at internet scale is a deep reservoir of people, ideas and yes, money, that Gilliam believes changes how we do almost everything - and makes almost anything possible.

30 Maj 20149min

a16z Podcast: Bending Every Pixel to Your Will -- Optimizely and the Next Wave of Internet Tools

a16z Podcast: Bending Every Pixel to Your Will -- Optimizely and the Next Wave of Internet Tools

Optimizely is a superb example of the democratization of software development. You don't need an engineering degree to fire up Optimizely and start testing how design changes on your website -- down to the pixel level -- affect things like time on site, closing sales, navigation, etc. The a/b testing Optimizely offers is just one example of a new wave of tools born of the internet, and designed for how people work, shop, research and entertain themselves online. Andreessen Horowitz's Scott Weiss, who is taking a seat on the Optimizely board following a16z's recent investment, a16z Partner Tom Rikert, and Optimizely co-founder Dan Siroker discuss the next wave of internet tools, where entrepreneurs are headed next, and how virtually anyone can avail themselves of this technical brawn.

20 Maj 201420min

a16z Podcast: The Two Big Problems With Thomas Piketty’s “Capital in the Twenty-First Century”

a16z Podcast: The Two Big Problems With Thomas Piketty’s “Capital in the Twenty-First Century”

“At a moment of great concern about inequality, now comes a learned tome proclaiming the gravity of the inequality problem,” says Larry Summers in a conversation with Andreessen Horowitz’s Balaji Srinivasan. “It’s a stunning thing, and it must reflect positively on the growing intellectualism of the society that a book like that could be a best-seller.” But that doesn’t mean Piketty got it right, adds the former Secretary of the Treasury and current a16z special advisor. Summers describes the two big problems he sees with Piketty’s argument, and how the forces of technology and globalization are better lenses through which to view and explain income inequality.

15 Maj 201415min

Populärt inom Business & ekonomi

framgangspodden
badfluence
varvet
uppgang-och-fall
rss-borsens-finest
svd-ledarredaktionen
avanzapodden
fill-or-kill
affarsvarlden
borsmorgon
dynastin
rss-dagen-med-di
rikatillsammans-om-privatekonomi-rikedom-i-livet
rss-kort-lang-analyspodden-fran-di
kapitalet-en-podd-om-ekonomi
lastbilspodden
ett-rikare-liv
market-makers
ekonomiekot-extra
tabberaset