a16z Podcast: Apple and Google Won the Mobile OS War, But a New War Has Already Begun

with James J. Collins, Vijay Pande (@vijaypande), and Hanne Tidnam (@omnivorousread) The idea of 'designing biology' -- once science fiction -- has over the last 20 years become just... science. In this episode, a16z bio general partner Vijay Pande with Hanne Tidnam talk all about the field of synthetic biology with James J. Collins, professor of bioengineering at MIT. Collins, whose work in synthetic biology and systems biology pioneered the field, has also launched a number of companies and received numerous awards and honors (including a MacArthur "Genius" Award, an NIH Director's Pioneer Award, and Sanofi-Institut Pasteur Award). This wide-ranging conversation about the birth of synthetic biology covers everything from the founding story of the discipline to what "engineering and designing" biology really looks like in action -- when instead of engineering electrons, you are engineering toggle switches for genes -- to the disciplinary differences (and synergies) between how biologists and engineers see the world. What are the engineering and design principles, techniques, approaches that work best when applied to science? How does building a company in this new space look different, in terms of platforms and products? And how is this new field changing education in science, all the way down to kits that allow you to play with the machinery of a cell... at home... and even in middle school?

11 Jan 201935min

The past and future of marketplace startups -- where are we? Ever since eBay popularized an internet meeting place for buyers and sellers of, well, just about everything, we’ve been waiting for 100 other at-scale marketplaces for everything else, including services. So in this hallway-style episode of the a16z Podcast (originally recorded as a video) Li Jin -- co-author with Andrew Chen of this post -- chats with a16z Deal & Research team operating partner about why there aren’t 100 thriving marketplaces for services yet... And what’s changing to make this next wave of marketplace startups super exciting. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

9 Jan 201941min

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Tyler Cowen (@tylercowen) This episode of the a16z Podcast features the rare combination of a16z co-founders Marc Andreessen and Ben Horowitz in conversation, together, with economist Tyler Cowen (chair of economics at George Mason University and chairman and general director of the Mercatus Center there, and host of his own podcast.) The conversation originally took place at our most recent annual innovation Summit -- which features a16z speakers and invited experts from various organizations discussing innovation at companies large and small, as well as tech trends spanning bio, consumer, crypto, fintech, and more. This discussion covers Ben and Marc's marriage, er, partnership; the evolution of VC and "talent as a network"; and where are we right now on industries being affected by tech (such as retail) and tech trends (such as VR/AR and wearables) -- and where are we going next? Finally, is software eating culture... or is it the other way around?

29 Dec 201838min

In his book (and podcast), Brian McCullough chronicles the history and evolution of the internet -- from college kids in a basement and the dot-com boom, to the applications built on top of it and the entrepreneurs behind them. General partner Chris Dixon chats with McCullough about How the Internet Happened -- and more broadly, about how tech adoption and innovation happens. The content provided here is for informational purposes only, and does not constitute an offer or solicitation to purchase any investment solution or a recommendation to buy or sell a security; nor it is to be taken as legal, business, investment, or tax advice. In fact, none of the information in this or other content on a16zcrypto.com should be relied on in any manner as advice. Please see https://a16zcrypto.com/disclosures/ for further information.

24 Dec 201846min

with Andy Milenius (@realzandy), Jesse Walden (@jessewldn), and Sonal Chokshi (@smc90) The history, evolution, and use of money revolves around the important concept of debt: It’s what allows us to “time travel” and build toward the future — growing livelihoods, businesses, and the overall economy as a result. When it comes to crypto, however, this concept plays a key role as a way to potentially stabilize the volatility of cryptocurrencies, and more importantly, provide a more stable medium of exchange so key applications can be built on top of blockchains. That’s where stablecoins (cryptocurrencies pegged to a more stable asset, such as fiat dollars) come in. Because they’re deployed on top of blockchains, they retain the advantages of cryptocurrencies — digital, global, easily transferable, decentralized. And because open source networks are more transparent and auditable, these systems are far less opaque than, say, the huge house of cards that collapsed in the case of the 2008 financial crisis. But beyond bringing more people into a better financial system, why do stablecoins like Dai — and Maker, one of the oldest decentralized autonomous organizations (DAOs) on the Ethereum blockchain — matter to the crypto developer community? To banks? To anyone who thinks about the future of innovation… or even the future of the firm, and the future of work? How do (and don’t) DAOs and these kinds of smart contracts change everything we know about management and software development? This episode of the a16z Podcast explores the answers to these questions and more, with Maker CTO Andy Milenius in conversation with Sonal Chokshi and a16z crypto partner Jesse Walden. Here are just two quotes from our jam session: Blockchains are an "open-access, permissionless, choose-your-own adventure story"; and smart contracts are an mp3-like "compression format" for scaling trust. Let the music begin! Please note that the a16z crypto fund is a separate legal entity managed by CNK Capital Management, L.L.C. (“CNK”), a registered investor advisor with the Securities and Exchange Commission. a16z crypto is legally independent and operationally separate from the Andreessen Horowitz family of fund and AH Capital Management, L.L.C. (“AHCM”). In any case, the content provided here is for informational purposes only, and does NOT constitute an offer or solicitation to purchase any investment solution or a recommendation to buy or sell a security; nor it is to be taken as legal, business, investment, or tax advice. In fact, none of the information in this or other content on a16zcrypto.com should be relied on in any manner as advice. You should consult your own advisers as to legal, business, tax and other related matters concerning any investment. Furthermore, the content is not directed to any investor or potential investor, and may not be used or relied upon in evaluating the merits of any investment and must not be taken as a basis for any investment decision. No investment in any fund advised by CNK or AHCM may be made prior to receipt of definitive offering documentation and due diligence materials. Finally, views expressed are those of the individual a16z crypto personnel quoted therein and are not the views of CNK, AHCM, or their respective affiliates.

21 Dec 201850min

with Bernard J. Tyson (@bernardjtyson) and Ben Horowitz (@bhorowitz) Bernard J. Tyson is the chairman and CEO of Kaiser Permanente, a $73 billion non-profit health organization that provides healthcare and coverage with more than 22,000 physicians caring for more than 12.2 million members across 9 states. In  this conversion with a16z co-founder and general partner Ben Horowitz -- which originally took place at a16z's annual innovation summit, which focuses on building the future and included an entire theme focused on bio and healthcare -- Tyson shares his thoughts on the state of healthcare today and where it might be going. How does an end-to-end healthcare system (like Kaiser's) work in terms of assuming risk and responsibilities, while also maximizing value and lifetime care over a “head in the bed”? What's the impact of -- and challenges in adopting -- technology in healthcare today? And finally, how does one strike a balance between affordability, quality, and lifetime care... and between innovating and addressing immediate needs? All this and more in this episode. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

21 Dec 201848min

with Brian Armstrong (@brian_armstrong), Chris Dixon (@cdixon), and Sonal Chokshi (@smc90) Where are we, really, right now -- in terms of what we can/ can't do with crypto today? And what will it take to get from vision to mainstream reality? This episode of the a16z Podcast covers all this and more. It's based on a conversation that took place between Coinbase CEO and cofounder Brian Armstrong and a16z crypto general partner Chris Dixon, interviewed by a16z editor in chief Sonal Chokshi, at our at our annual Summit in November 2018 -- following a series of presentations that covered everything from early adoption, myths, and the global need for crypto; to crypto as seen through the lens of trust; to key terms and concepts that enable entirely new use cases on top of crypto. But what are the missing pieces needed to get us there? Is crypto is too much like a religion... and if so, how does one build a company, culture, community in such an intense environment? Where does the history of open source come in? And finally, what are some of the most interesting applications and trends in the space? Please note that the a16z crypto fund is a separate legal entity managed by CNK Capital Management, L.L.C. (“CNK”), a registered investor advisor with the Securities and Exchange Commission. a16z crypto is legally independent and operationally separate from the Andreessen Horowitz family of fund and AH Capital Management, L.L.C. (“AHCM”). In any case, the content provided here is for informational purposes only, and does NOT constitute an offer or solicitation to purchase any investment solution or a recommendation to buy or sell a security; nor it is to be taken as legal, business, investment, or tax advice. In fact, none of the information in this or other content on a16zcrypto.com should be relied on in any manner as advice. You should consult your own advisers as to legal, business, tax and other related matters concerning any investment. Furthermore, the content is not directed to any investor or potential investor, and may not be used or relied upon in evaluating the merits of any investment and must not be taken as a basis for any investment decision. No investment in any fund advised by CNK or AHCM may be made prior to receipt of definitive offering documentation and due diligence materials. Finally, views expressed are those of the individual a16z crypto personnel quoted therein and are not the views of CNK, AHCM, or their respective affiliates. Please see https://a16zcrypto.com/disclosures/ for further information.

18 Dec 201832min

with Jeffrey Katzenberg, Meg Whitman (@MegWhitman), and Marc Andreessen (@pmarca) In this episode of the a16z Podcast, based on a discussion that took place at our annual a16z Summit, Marc Andreessen interviews Jeffrey Katzenberg -- formerly CEO and co-founder of DreamWorks SKG (and chairman of Walt Disney Studios during some of its biggest hits), now co-founder of tech holding company WndrCo -- and Meg Whitman -- former President and CEO of Hewlett Packard Enterprise, and now CEO of Quibi ("quick bites"), focused on short-form mobile video. Both Katzenberg and Whitman have known each other for years, but they resided in two different worlds -- entertainment and software -- which are now merging, not only through their current venture but more broadly, given fundamental shifts in the entertainment and media landscape. In this conversation, Andreessen probes them on where Hollywood comes in (or doesn't); the intersection of software and new media, including how content creation changes as platforms evolve; and what’s next for entertainment. Along they also touch on their unique working relationship, and leadership lessons learned...

5 Dec 201844min