a16zPodcast: People Marketplaces Take On One of the Last Great E-Commerce Opportunities -- Groceries

Moore's Law -- putting more and more transistors on a chip -- accelerated the computing industry by so many orders of magnitude, it has (and continues to) achieve seemingly impossible feats. However, we're now resorting to brute-force hacks to keep pushing it beyond its limits and are getting closer to the point of diminishing returns (especially given costly manufacturing infrastructure). Yet this very dynamic is leading to "a Cambrian explosion" in computing capabilities… just look at what's happening today with GPUs, FPGAs, and neuromorphic chips. Through such continuing performance improvements and parallelization, classic computing continues to reshape the modern world. But we're so focused on making our computers do more that we're not talking enough about what classic computers can't do -- and that's to compute things the way nature does, which operates in quantum mechanics. So our smart machines are really quite dumb, argues Rigetti Computing founder and CEO Chad Rigetti; they're limited to human-made binary code vs. the natural reality of continuous variables. This in turn limits our ability to work on problems that classic computers can't solve, such as key applications in computational chemistry or large-scale optimization for machine learning and artificial intelligence. Which is where quantum computing comes in. But what is quantum computing, really -- beyond the history and the hype? And where are we in reaching the promise of practical quantum computers? (Hint: it will take a hybrid approach to get there.) Who are the players -- companies, countries, types of people/skills -- working on it, and how can a startup compete in this space? Finally, what will it take to get "the flywheel" of application development and discovery going? Part of the answer comes full circle to the same economic engine that drove previous computing advances, argues Chris Dixon; Moore's Law, after all, is more of an economic principle that combined the forces of capitalism, a critical mass of ideas, and people moving things forward by sheer will. Quantum computing is finally getting pulled into the same economic forces as well.

13 Maj 201726min

A board veteran who has sat on both sides of the table, CEO of PagerDuty Jennifer Tejada shares what you gain from board membership (vs. being only an operator). How does being a board member change you as a CEO, and vice versa? Recorded as part of our annual Director's College held at Stanford University in April 2017, Tejada (in conversation with a16z operating partner Margit Wennmachers) in this episode of the a16z Podcast offers advice about the importance of diligence on both sides, subject matter expertise, and complex dynamics among fellow board members. Tejada also talks about how to make the best use of your board as a CEO... including what's most important when managing them (hint: no surprises!).

11 Maj 201720min

It’s the end of the beginning — not the beginning of the end — for wearables, argue the guests in this episode of the a16z Podcast. Especially as we move from the first, to the next, generation of wearable devices: not just activity trackers and watches but VR/AR gear, “hearables”, continuous glucose monitors, and more. The quantified self movement then takes these empirical tracking- and data-gathering tools to better reason about what works and doesn’t work in our bodies to help us solve problems and live better lives. Yet the act of gathering data isn’t the hard part… it’s linking them to insights and outcomes. Because we really do have very little data about what works at a collective let alone an individual level. With a new age of biohacking upon us — where people can apply engineering principles to manipulate what we take into our bodies (inputs) to tune how we perform (outputs) — can we finally embrace these tools? What will it take to make something that’s mainly a niche activity/community (quantified self was formally started a decade ago!) into something more mainstream for all? (Hint: it involves cookie recipes.) And finally, what are the societal implications of all this, from avoiding data dystopias to embracing the consumerization of government projects too? Joining us to explore these questions and more (in conversation with Sonal Chokshi), we have: neuroscientist and data scientist Rachel Kalmar, currently a fellow at The Berkman Klein Center for Internet and Society at Harvard University; co-founder of The Quantified Self blog and community Gary Wolf; and Geoffrey Woo, co-founder and CEO at Nootrobox (an a16z company).

1 Maj 201731min

The first thing that comes to mind when treating health problems is the need to take a pill (or other pharmaceutical) of some kind. But could a digital therapeutic -- a software-based intervention -- not only complement, but possibly even replace pills? In this episode of the a16z Podcast, CEO of Omada Health Sean Duffy and a16z bio fund general partner Vijay Pande (in conversation with Malinka Walaliyadde) discuss the potential of digital therapeutics, which use software, design, and other carefully orchestrated elements to change behavior. (Because what is software, really, observes Duffy, but a way of changing behavior?) Of course, digital therapeutics can augment medical treatment and make doctors better -- but what advantages do such methods have over pills? How do we know it’s really working? And what role does digital health have in the continuing push towards value-based care?

28 Apr 201726min

In this hallway-style episode of the podcast, a16z partners Connie Chan and Kyle Russell discuss recent announcements at Facebook's annual developer conference, F8, in the context of trends such as: messaging and QR codes; brain computer interfaces; augmented reality and social VR; and, bots (again). As online platforms built on "real" identity and brands bring more of the real world into the digital realm, will we experience filter fatigue... or will the mundane become more profound? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

25 Apr 201728min

Is it real or science fiction to dream of being able to treat… getting old? In this episode, we discuss with Dr. Thomas Rando from Stanford (who directs the Glenn Center for the Biology of Aging), Kristen Fortney, CEO of BioAge, and a16z’s general partner Vijay Pande where we are in the field of “geroscience” — the idea of studying, well, aging itself, and aging as the root risk for all aging related disease. Far from science fiction, recent discoveries have given us a whole crop of promising breakthroughs to treat aging, such as parabiosis (young blood infused into old blood), senolytics, and rapamycin, and more. What we’re beginning to see is a fundamental shift away from the idea of searching for immortality and towards the idea of increasing "health span” — where prevention means much more than eating healthier or exercising more. Are we moving from Dx to Rx to — perhaps Px? What will it look like when anti-aging therapies actually begin to be delivered to us: small molecule or protein or an antibody — or something else entirely? A pill or a blood transfusion treatment? A vaccine for aging? And finally, what has to change — conceptually, scientifically, logistically, in regulation -- to get these therapies into the hands of all? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

18 Apr 201729min

A crisis is an opportunity to change one's culture, to model scenarios and set up a crisis plan/process, to become a better company. But it's also a bit like therapy, from the act of asking probing questions to get at the facts ... to dealing with emotions and conflicting agendas. In this hallway-style conversation with a16z's Margit Wennmachers and Kim Milosevich -- who previously shared the why, how, and when of public relations -- we (with Sonal Chokshi) explore the process and mindsets behind the outcomes of a crisis in lieu of specific examples. Because it's something that seems so obvious to those who are on the inside (but even then it's really not!), yet is actually a bit of a "black box" to founders and others who aren’t familiar with crisis comms 101. What constitutes a crisis? Can someone inside a company "call it" early and prevent a crisis from becoming a bigger deal? How do you respond when there's a lag or too much time between acknowledging the issue and finding out all the facts? Who should be in the (war) room where it happens? Should you share the off-the-record background story with reporters? How do you know when a crisis begins and ends -- or that you're ready for a "comeback" story? We explore all this and more in this episode of the a16z Podcast. One thing's for sure though: It may seem like a public relations or media problem -- but it's really a business problem, and is often tied to internal culture and values. So how to make that an opportunity (without being opportunistic about it)?

13 Apr 201733min

Here’s what we know about open source: Developers are the new buyers. Community matters. And there will never be another Red Hat (i.e., a successful “open core” business model … nor do we necessarily think there should be). Yet open source is real, and it’s here to stay. So how then do companies build a viable business model on top of open source? And not only make money, but become a huge business, like the IBMs, Microsofts, Oracles, and SAPs of the world? The answer, argues James Watters, has more to do with good software strategy and smart enterprise sales/procurement tactics (including design and a service-like experience) than with open source per se — from riding a huge trend or architectural shift, to being less transactional and more an extension of your customer’s team. Watters, who is the SVP of Product at Pivotal (part of VMWare and therefore also Dell-EMC), is a veteran of monetizing open source — from OpenSolaris (at Sun Microsystems) to Springsource (acquired by VMWare) to Pivotal Cloud Foundry — with plenty of failures, and successes, along the way. He shares those lessons learned in this episode of the a16z Podcast with Sonal Chokshi and general partner Martin Casado (who was co-founder and CTO of Nicira, later part of VMWare before joining Andreessen Horowitz). These lessons matter, especially as open source has become more of a requirement — and how large enterprises bet on big new trends.

11 Apr 201729min