a16z Podcast: The Marketplace Rules

Once we sequenced the human genome, we'd know the cause of -- and therefore be able to help cure -- all diseases... Or so we thought. Turns out, 20,000 genes (and counting) didn't really explain why disease occurred. Sure, some could be explained by mutations in a single genome, but most, like cancer, are too damn complex. And while the focused, singular approach to understanding disease did yield some useful therapeutics, it's now reached its limits. It hasn't helped much on the diagnostics (and early detection) front, either. That's where a systems approach to bio comes in, drawing on machine learning techniques as well as a sort of "Moore's Law" for genomics that's driving costs down, and fast. We're now focusing on the 99% of the genome that hasn't really been understood yet in terms of how they affect the human body and disease. But what will it take for such an approach to succeed? For one thing, it involves building an applications layer on top of the sequencing layer -- so can we borrow lessons from how the computing industry (from chips to apps) evolved here? What are some of the constraints unique to the healthcare system? In this episode of the a16z Podcast, Freenome CEO and co-founder Gabriel Otte and a16z bio fund partners Vijay Pande and Malinka Walaliyadde (in conversation with Sonal Chokshi) talk all things genomics and disease from science to business, also covering recent news like Illumina to what's next beyond human genomics to future trends. Including what the ultimate, Elysium-like magical diagnostic machine is (hint: the magical is mundane!).

18 Okt 201630min

From glittery reaction gifs modded by grandparents to rage faces on Reddit, stickers (gifs and other layered images) and emotive “biaoqing” have taken over messaging culture in China and beyond. Stickers are tied to filter culture, too — whether originating in real life as purikura photo sticker booths in Japan or digitally as Snapchat filters. Why are these forms of social communication so popular? Because sometimes you just want to say “I feel totally Nicki Minaj side-eye dot-GIF about this”, and no one can give a side-eye as good as Nicki Minaj can. But it’s not just about isolated expressions, celebrity stickers like Kimoji, or personalized bitmoji; stickers are shaping and codifying the way people talk to each other online in new and multi-layered ways. It’s even connected to mobile livestreaming, a phenomenon that’s taking off in China right now, in the most mundane (food eating streams) to subversive (seductive banana eating streams) ways. And how are all these memes tied to monetization and payments? In this episode of the a16z Podcast, ROFLCon co-founder and human-centered researcher/writer Christina Xu and Connie Chan in conversation with Sonal Chokshi take us on a wild tour of cultural messaging memes and messaging tech in China and beyond.

12 Okt 201647min

The most recent Oculus Connect event (the third and largest yet) has been lauded as bringing us closer than ever to the future promised for virtual reality or VR. There have been many hardware moves by many players, both recently and over the past year. Who's in it to win it? How far are we from the "holy grail" of headsets that will truly mainstream VR? Will the killer app -- or layer -- for VR be social? And is there enough enthusiasm and activity to get us past the "trough of disillusionment" that inevitably follows the "peak of inflated expectations" in the hype cycle for new technologies like VR? In this episode of the a16z Podcast, partners Chris Dixon, Benedict Evans, and Kyle Russell deep dive on all the gear and players in the VR ecosystem; the evolution of content beyond gaming (with a teeny hint at what a VR horror genre might look like); and how the high-end will push the medium forward for all. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

10 Okt 201635min

This special episode of the a16z Podcast is based on a Q&A from an early screening we hosted of Disney's Queen of Katwe, now in theaters. The movie -- directed by Mira Nair and based on a book by Tim Crothers -- depicts the true story of Ugandan chess prodigy Phiona Mutesi. The conversation, hosted by Ben Horowitz, features actor David Oyelowo who (among other roles, previously played Dr. Martin Luther King, Jr. in "Selma") and plays Robert Katende, the engineer-turned-mentor who taught community sports and chess to kids in the slums of Kampala, Uganda. photo credits: Prentiss Earl lll

30 Sep 201621min

From the silver age of on-prem software companies like SAP and Siebel Systems to the golden age of enterprise software-as-a-service, we're now seeing an explosion of data. All types, all sizes, and all over the place. And much of it is a sort of industrial "data exhaust", where companies aren't quite sure what question to ask of the data but are being bombarded with data due to the variety of data sources available today -- from websites to sensors (and therefore data capture) everywhere. Before there is even a signal in the noise. So how do you solve a problem like this-Data? Beyond requiring new types of plumbing and integrations, enterprises now expect -- given the age of mobile, web, cloud, and heck, let's add millennials to the mix too -- self service. To be able to ask, get, fit (curve-fit), predict. To take back the enterprise from the patchwork of integration and number of vendors we all have to deal with -- the scope of which most companies in fact are not truly aware of. It's about the lifecycle of data in the enterprise, argues Snaplogic founder and CEO Gaurav Dhillon in this episode of the a16z Podcast, in conversation with Scott Kupor. It's in fact about the evolution of data overall -- from data warehouses to "data lakes": in stages, from purification (like wrangling data) to bottling (prepping for consumption by data scientists) to making sense of streams and streams of data! The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

22 Sep 201628min

Just as "social networking" is a bland term that doesn't really capture the layers of what happens underneath (and on top of) social networking platforms, "crowdfunding" is a broader phenomenon than what the term and tools implies. Or so argue the guests on this episode of the a16z Podcast, Tilt co-founder and CEO James Beshara and a16z general partner Jeff Jordan with Sonal Chokshi. Crowdfunding isn't just about reaching a certain threshold to make something, but it's also about "pre-commerce" or "pretail" -- the next evolution in commerce, which involves the ability to suss out demand before production and sell directly to consumers. Crowdfunding is also about "social commerce" -- the ability to not only build community, but trigger collective action towards some goal. There's even a sort of Dunbar's number equivalent for crowdfunding, the tipping point at which the momentum of this collective action takes over (hint: it involves the magic number of 34%). Beyond crowdfunding, there are broader themes of economic change and behavior at play here -- whether it's people's tolerance for waiting and buying something before it exists; a new type of scarcity and desire for experiential buying; or makers creating or co-creating things publicly, and even incompletely. All we know is that we're at a watershed moment of sorts -- as evidenced by car manufacturer Tesla's pre-orders for its Model 3, which is not even going to be available for a few years. And yet...! The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

18 Sep 201627min

"Apple isn't just a tech company; it's a tastemaker." Remember the iconic ads of dancing silhouettes in black, with only the headphone wires visible in white? They were a critical part of the larger buy-Apple innovation narrative. So what happens now when those wires -- an emblematic and enduring image -- are no longer visible, as is the case with the removal of the traditional headphone jack in iPhone 7? It's part of a broader story, both about how product narratives are shared/told and about how innovation happens: "amazingly", subtly, and sometimes, invisibly. Some innovations, like preventing "battery anxiety" or building a platform ecosystem or even laying the tracks for a train that hasn't arrived yet ("ear computers" or "audible computing"? VR/AR? car?) take time. And a direction we may not be able to anticipate from the outside looking in. ...Or so argue the a16zers on this episode of the a16z Podcast featuring in-house analyst Benedict Evans and board partner Steven Sinofsky with Kyle Russell.

13 Sep 201633min

Sleep, productivity, and creatively are intimately linked, for better and for worse. And "we are living under a collective delusion that burnout is the way to succeed," observes Arianna Huffington, author of The Sleep Revolution. Not only does this affect our health and resilience, she argues, but the data shows that even though we are working longer hours than ever, we lose 11 days of productivity a year per employee due to sickness or diminished capacity. (It also hurts our ability to work in teams.) This isn't just a problem in the tech industry, either. BuzzFeed News senior writer Nitasha Tiku observes that "Any business book that's valorizing or diving into the life of a CEO is going to talk about how much he or she sleeps." But sleep isn't just a biological act, it's also a psychological (insomnia, anxiety, TV binge-watching?) as well as a socioeconomic one when you consider who gets to sleep (people higher or lower in the workplace hierarchy, other demographic factors?). And where does tech and the tech industry come in here? In this episode of the a16z Podcast, Huffington and Tiku discuss the hard realities of sleep -- everything from tech and culture to labor and the evolving nature of work.

6 Sep 201628min