a16z Podcast: On the Genomics of Disease, From Science to Business
a16z Podcast18 Okt 2016

a16z Podcast: On the Genomics of Disease, From Science to Business

Once we sequenced the human genome, we'd know the cause of -- and therefore be able to help cure -- all diseases... Or so we thought. Turns out, 20,000 genes (and counting) didn't really explain why disease occurred. Sure, some could be explained by mutations in a single genome, but most, like cancer, are too damn complex. And while the focused, singular approach to understanding disease did yield some useful therapeutics, it's now reached its limits. It hasn't helped much on the diagnostics (and early detection) front, either.

That's where a systems approach to bio comes in, drawing on machine learning techniques as well as a sort of "Moore's Law" for genomics that's driving costs down, and fast. We're now focusing on the 99% of the genome that hasn't really been understood yet in terms of how they affect the human body and disease. But what will it take for such an approach to succeed? For one thing, it involves building an applications layer on top of the sequencing layer -- so can we borrow lessons from how the computing industry (from chips to apps) evolved here? What are some of the constraints unique to the healthcare system?

In this episode of the a16z Podcast, Freenome CEO and co-founder Gabriel Otte and a16z bio fund partners Vijay Pande and Malinka Walaliyadde (in conversation with Sonal Chokshi) talk all things genomics and disease from science to business, also covering recent news like Illumina to what's next beyond human genomics to future trends. Including what the ultimate, Elysium-like magical diagnostic machine is (hint: the magical is mundane!).

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a16z Podcast: The Two Big Problems With Thomas Piketty’s “Capital in the Twenty-First Century”

a16z Podcast: The Two Big Problems With Thomas Piketty’s “Capital in the Twenty-First Century”

“At a moment of great concern about inequality, now comes a learned tome proclaiming the gravity of the inequality problem,” says Larry Summers in a conversation with Andreessen Horowitz’s Balaji Srinivasan. “It’s a stunning thing, and it must reflect positively on the growing intellectualism of the society that a book like that could be a best-seller.” But that doesn’t mean Piketty got it right, adds the former Secretary of the Treasury and current a16z special advisor. Summers describes the two big problems he sees with Piketty’s argument, and how the forces of technology and globalization are better lenses through which to view and explain income inequality.

15 Maj 201415min

a16z Podcast: Demystifying Venture Capital

a16z Podcast: Demystifying Venture Capital

What do venture capitalists actually do all day? And what is the path that leads to a career investing in startups? Hummer Winblad’s Ann Winblad, Cowboy Ventures' Aileen Lee, Aspect Ventures' Theresia Gouw, Intel Capital veteran and UPWARD founder Lisa Lambert, and Andreessen Horowitz’s Margit Wennmachers discuss VC trends, the importance of technical chops, and how to build the next generation of entrepreneurs and investors. And finally, in front of an appreciative crowd attending the UPWARD event at a16z, Ann Winblad reveals the secret to truly kicking ass.

2 Maj 201437min

a16z Podcast: When Your PC Expires, What's Next?

a16z Podcast: When Your PC Expires, What's Next?

Computing is in the midst of a transformation that puts your future device purchases up for grabs. It’s a safe bet that everyone will have a phone, and as the last holdouts switch over, that will inevitably mean a smartphone. But when your PC finally gives up the ghost, are you going to buy another PC? Perhaps a tablet? Or will another large screen device –a really big phone - be the ticket? Maybe just get all three? Benedict Evans and Steven Sinofsky discuss why laptops and tablets are competing for the same customers, and why it’s never wise to defend any form-factor to the death.

30 Apr 201416min

a16z Podcast: Apple and the Fate of Tablets

a16z Podcast: Apple and the Fate of Tablets

Apple’s recent earnings sent the stock soaring. What drove that investor exuberance had everything to do with iPhone sales (and the China market), and very little to do with the iPad – the sales of which were essentially flat over the past year. Chris Dixon and Benedict Evans look at the fortunes of the world’s best-selling tablet, and what that means for the balance of power in the computing world. Are smartphones supplanting tablets for most uses? Are developers so focused on creating apps for the latest handsets the tablet is becoming an afterthought?

25 Apr 201421min

a16z Podcast: The Future Of Television

a16z Podcast: The Future Of Television

Can technology companies show up and disrupt television with an onslaught of new gizmos and services, or is content still the controlling factor? What will it take in terms of money, business model and time to upend the TV model that has stubbornly persisted for decades? Will the old platforms and players dominate, or is now the time for new players to take charge? Andreessen Horowitz’s Benedict Evans and Zal Bilimoria discuss the future of television.

18 Apr 201419min

a16z Podcast: Engineering a Revolution at Work

a16z Podcast: Engineering a Revolution at Work

From file cabinets to typewriters, spreadsheets and word processing the tools we use for work change not only what we do, but the culture of our workplace. Steven Sinofsky, a veteran of building software tools for productivity, discusses the latest revolution in technology-enabled tools with Benedict Evans. Why today’s cloud-based tools change the role of managers, and why the perfect tool will never exist (nor would you want it to).

10 Apr 201423min

a16z Podcast: China and Tech

a16z Podcast: China and Tech

China has been a tough market to crack for U.S. internet companies. One of the key reasons is China has its own crop of hugely successful and highly innovative companies. Andreessen Horowitz’s Chris Dixon, Connie Chan and Benedict Evans highlight the key players in China, and what non-Chinese companies can learn from them. Where Chinese companies and money are headed next.

30 Mars 201417min

a16z Podcast: Oculus and the (Mind-Blowing) Reality of Virtual Reality

a16z Podcast: Oculus and the (Mind-Blowing) Reality of Virtual Reality

Up until now virtual reality has been a disappointment for all those people pining for their own personal holodeck. But advances in the components required to create a truly immersive digital 3D experience have finally broken through much of what has been holding virtual reality back. As a consequence, Oculus VR is building something that is nothing short of a new medium. Andreessen Horowitz’s Chris Dixon, Balaji Srinivasan and Gil Shafir discuss the present and future potential of virtual reality. Take heart, the holodeck can’t be far away now.

28 Mars 201412min

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