a16z Podcast: The Business of Continual Change

Over the last 20 years, the idea of “designing biology” has gone from science fiction to just science, as the field of synthetic biology has exploded, with applications from therapeutics to manufacturing and more. In this episode from January 2019, one of the pioneers in the field, professor James J. Collins of MIT, joins a16z general partner on the Bio + Health fund, Vijay Pande, and editorial partner Hanne Winarsky, to discuss the origins of synthetic biology or "synbio", to what "engineering and designing" biology really looks like in action and the disciplinary differences between how biologists and engineers see the world.

6 Juli 202236min

In this episode from July 2019, Kurt House, CEO and co-founder of Kobold Metals, John Thompson, professor of earth and geosciences at Cornell; and Connie Chan, a16z general partner for consumer, talk with editorial partner Hanne Winarsky about the way technology is transforming how we find cobalt, and the mining industry as a whole, as well as the science behind why cobalt is so critical for batteries, the data and knowledge behind mining today vs the past, and more.

29 Juni 202233min

In this episode from October 2019, People.AI founder and CEO Oleg Rogynskyy and a16z partner Peter Lauten discuss with Das Rush about what the rise of AI in B2B means for enterprises, workers, and startups. They explain why AI provides a strong first mover advantage to enterprises that adopt it early; how it can automate lower level tasks, maximize our focus, and, ultimately, make our work more meaningful; and for startups, they provide a playbook for seizing the next AI opportunity.To learn more about the latest in AI, ML, data, and how enterprise are working with these technologies, go to future.com/data.

23 Juni 202224min

In this episode from October 2019, a16z co-founder Marc Andreessen and former a16z podcast showrunner Sonal Choksi bring on MIT economist and bestselling author Andrew McAfee to discuss why the lessons of human growth in times past, from the Industrial Revolution onwards, might not apply to our future. It used to be that the only way for humanity to grow — and progress — was through destroying the environment. But is this interplay between human growth vs. environment really a zero-sum game? Even if it were true in history, is it true today? If capitalism is not responsible for environmental degradation, than who or what is? And where does (and doesn’t) technology come in?The conversation is based on McAfee’s 2019 book More from Less: The Surprising Story of How We Learned to Prosper Using Fewer Resources -- and What Happens Next,  ranging broadly across many areas of growth, from the future of energy and agriculture to the role of capitalism and technology today and tomorrow, from dematerialization  to Tesla, Buckminster Fuller, and more.

15 Juni 202247min

Blockchain, crypto, web3 – these terms get thrown around a lot and sometimes interchangeably, but what are the actual connections between them? And what are some mental models and analogies for thinking about this blossoming area of computer science?To dig in on these topics and more, we have another crossover episode this week, part of our occasional series where we share curated episodes from other shows that we think you’ll enjoy.This time, we’re featuring one of the first episodes from "web3 with a16z", a new show which just launched last week. Hosted by Sonal Choksi and featuring the team at a16z crypto as well as leading scientists and makers in the space, this show is about the next generation of the internet, how builders and users now have the ability to "own" pieces of the internet, unlocking a new wave of creativity and entrepreneurship. This episode features a16z crypto general partners Chris Dixon and Ali Yahya, and Tim Roughgarden, head of research at a16z crypto, in conversation with Sonal Choksi.

8 Juni 202237min

In this special “innovation overview” episode from April 2021, the a16z crypto team and other experts take you from the ground up of crypto and web3 — from the basics, to more recent developments, and beyond – through the lens of an oral essay with brief segments on what crypto is, how it really works, and where it’s going.We chose this particular archive episode this week in honor of a new show that just launched: web3 with a16z. Hosted by Sonal Choksi, the previous showrunner of the a16z podcast network and longtime host of this show, and featuring the team at a16z crypto as well as leading scientists and makers in the space, this show is about the next generation of the internet, how builders and users now have the ability to "own" (web3) pieces of the internet, unlocking a new wave of creativity and entrepreneurship. The first two episodes are out this week, so check out and subscribe to “web3 with a16z” wherever you get your podcasts.

2 Juni 202239min

In this episode from February 2017, a16z co-founder Ben Horowitz and Jason Rosenthal, former Lytro CEO (now Vice President, Subscription Services, at Google) share stories and lessons learned from doing whatever they could to help their companies survive in hard times, including making and living through major pivots, selling new products before they were ready, figuring out financing with market and industry headwinds against them, and more. From their days together at LoudCloud to Jason’s experience at Lytro, and beyond, a common theme emerges: a CEO’s job is lonely in these moments and the hardest thing about a big pivot or change might be in finding the courage to make the decision in the first place.

26 Maj 202233min

In this episode from February 2021, early Amazon execs Colin Bryar and Bill Carr -- in conversation with a16z's Sonal Chokshi -- go beyond the well-known artifacts of Amazon innovation, like the memo and the press release, and share the leadership principles, decision making practices, and operational processes that helped Amazon continue to innovate, invent new products and learn from its mistakes, as it scaled. It’s all based on their book, Working Backwards: Insights, Stories, and Secrets from Inside Amazon, drawing from the 27 years combined experience of being in the room where it happened at Amazon.

18 Maj 20221h 4min