a16z Podcast: Damage-free Genome Editing -- Next in CRISPR
a16z Podcast26 Juni 2019

a16z Podcast: Damage-free Genome Editing -- Next in CRISPR

Two recent scientific journal papers show what's possible when CRISPR moves from cutting DNA tool to a full-fledged platform -- expanding its toolkit for medicine across R&D, therapeutics, and diagnostics:

"Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration" in Nature -- by Sanne Klompe, Phuc Vo, Tyler Halpin-Healy, and Samuel Sternberg (of Columbia University)
"RNA-guided DNA insertion with CRISPR-associated transposases" in Science -- by Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan Schmid-burgk, Kira Makarova, Eugene Koonin, and Feng Zhang (of the Broad Institute)

What do these two papers -- both about techniques for getting rid of the need to cut the genome to edit it -- make possible going forward, given the ongoing shift of biology becoming more like engineering? Where are we in the wave of the genome engineering "developer community" building on top of CRISPR with a constantly growing suite of programmable functionalities? a16z bio general partner Jorge Conde and bio deal team partner Andy Tran chat with Hanne Tidnam about these trends -- and these two papers -- in this short internal hallway-style conversation, part of our new a16z Journal Club series.

This podcast is also part of our new a16z bio newsletter, which you can sign up for at a16z.com/subscribe

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a16z Podcast: The Rise of Full Stack Startups

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Suppose you develop a new technology that is valuable to some industry. The old approach was to sell or license your technology to the existing companies in that industry. The new approach is to build a complete, end-to-end product or service that bypasses existing companies. Andreessen Horowitz’s Chris Dixon, Balaji Srinivasan and Benedict Evans discuss the reasons behind, and advantages of, going “full stack.”

27 Mars 201418min

a16z Podcast: Searching for Mobile’s Own PageRank

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The mobile experience is still in its 1995 Yahoo phase, a sea of apps and websites without an easy way to find what you want and need on your smartphone. What will be mobile’s version of PageRank, the algorithm that made the web manageable? What is the interaction model and the form - app, card, URL – that will help us find, explore and engage with people, products and services from our mobile devices? Andreessen Horowitz’s Chris Dixon, Benedict Evans and Balaji Srinivasan delve into the options.

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a16z Podcast: Where is the Technology That "Matters?" Right Here

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