Food, Drugs, and Tech—100 Years of Public Health

In his book (and podcast), Brian McCullough chronicles the history and evolution of the internet -- from college kids in a basement and the dot-com boom, to the applications built on top of it and the entrepreneurs behind them.General partner Chris Dixon chats with McCullough about How the Internet Happened -- and more broadly, about how tech adoption and innovation happens. They discuss lessons learned, how innovation doesn’t happen in a straight line, and what the past can tell us about the next phase of the internet and technology.

10 Mars 202247min

original episode notes and transcript here: https://future.a16z.com/podcasts/textiles-technology-science-math-cultures-civilization/Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. The third of these three special rerun episodes is a conversation that originally took place in October 2020, in the midst of the pandemic – and perfectly captures the signature identity of this show until now, and Chokshi's work, which is at the intersection of technology and humanity. In it, she and Virginia Postrel, author of the book The Fabric of Civilization: How Textiles Made the World cover everything from science and math across several fields, to commerce to management & measurement, to the always-meta narrative of HOW innovation happens… As a reminder: the a16z marketing & Future team will be putting this feed on hiatus while they relaunch it with a new host; in the meantime, you can continue to follow Sonal's work both here at a16z and other projects on Twitter @smc90. Thank you as well to our brilliant audio editors, expert guests, and several others here -- but most of all, thank you to YOU: for listening, sharing, engaging, and coming along with us on this journey the past decade! Stay tuned for more.

21 Feb 20221h 12min

original episode notes and transcript here: https://future.a16z.com/podcasts/innovating-in-bets/Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. The second of these three special rerun episodes is a conversation that originally took place spring/summer 2019, pre-pandemic (ah, that we could remember that time!) – between a16z co-founder Marc Andreessen and Sonal interviewing author, consultant/advisor, and former pro poker player Annie Duke, on one of her first few appearances with us. It’s a conversation quite unlike her other conversations, and one in a series of special joint interviews Marc and Sonal did. So there's a lot of high-speed talking, but the three cover a broad range of topics relevant to both businesses and individuals: on skill vs luck, on outcomes vs process, on asking the right questions, on how to communicate in probabilities within an organization or team, and, on how NOT making a decision is also a decision and why that matters. Be sure to also check out this feed for the followup conversation with Annie, Jeff Jordan, and Sonal on the specifics of HOW to Decide as well -- the practical and organizational implementations. (Because the a16z Podcast became an early go-to for book authors to release their books, Annie agreed to share her next book with us first.) But overall, these evergreen episodes are really all about INNOVATION, which is another signature theme in defining the identity of the a16z Podcast…

20 Feb 202248min

original episode notes and transcript here: https://future.a16z.com/podcasts/pleistocenepark-geoengineering-iceagebiome/Longtime podcast showrunner (2014-2022), primary host, and editor Sonal Chokshi shares three best-of episodes as she shifts gears and the show goes on hiatus until relaunched with a new host. The first of these three special rerun episodes is a conversation that originally took place in summer 2017, but both the work discussed in here – on making a really wild (quite literally wild;) geo-engineering idea at massive scale real – is still actively, relevant, and frequently discussed today (it’s on bringing back lab-grown woolly mammoths, which was also discussed in the 2020 documentary with Stewart Brand, We Are As Gods). But it's also all about how we humans can and do use the power of narrative to drive great feats of change, including engineering. This has been a signature theme in forming the identity of the a16z Podcast, and the conversation that follows is one that takes place among three tech & science editors, including one of our former colleagues (who also was a host on this podcast for 4 years).links: https://www.theatlantic.com/magazine/archive/2017/04/pleistocene-park/517779/https://www.weareasgods.film/

19 Feb 202231min

Welcome to the a16z podcast. Today we’re talking about the mindsets and frameworks founders should know about when navigating the mergers and acquisitions or M&A process, both before and after – including how to think about the pricing dynamics, factors that go into the decision-making process, and what to expect from the integration once the deal is done.A16z editorial partner Zoran Basich recently talked to two a16z experts here to give us their big-picture view of the most important things to know – for founders seeking to acquire companies and how they might think about it, or those considering selling a company, or just those deciding to merge with an acquirer.Blake Kim is a partner on our Enterprise Network team and a former investment banker who works with companies on strategic partnerships; he also recently co-wrote a post on Future outlining all the different exit options and considerations for companies. And general partner Martin Casado discusses common M&A issues and shares his experiences both as observer and participant – including the challenges of integration, which he saw from the inside with Nicira, which he cofounded and was acquired by VMware for $1.26 billion in 2012, and where he remained for years to lead its networking and security business unit.As a reminder, none of the following should be taken as investment advice. Please see a16z.com/disclosures for more important information.They start the discussion by outlining the frameworks for understanding M&A dynamics, including the “kingmaking dynamic” and the difference between “selling your company” and “getting acquired.”

26 Jan 202225min

Innovation in the data center has been constrained by the traditional model of suppliers providing fixed-function chips that limit how much the biggest data center operators can differentiate. But programmable chips have emerged that allow these companies to not only increase performance, but innovate throughout the pipeline, from operating system to networking interface to user application.This is a major trend among "hyperscalers," which are some of the world’s most well known companies running massive data centers with tens of thousands of servers. We’re talking about companies like Amazon, Facebook, Microsoft, Google, Apple, Alibaba, Tencent.To talk about the trends in data centers and how software may be “eating the world of the data center,” we talked this summer to two experts. Martin Casado is an a16z general partner focused on enterprise investing. Before that he was a pioneer in the software-defined networking movement and the cofounder of Nicira, which was acquired by VMWare. (Martin has written frequently on infrastructure and data-center issues and has appeared on many a16z podcasts on these topics.)He’s joined by Nick McKeown, a Stanford professor of computer science who has founded multiple companies (and was Martin’s cofounder at Nicira) and has worked with hyperscalers to innovate within their data centers. After this podcast was recorded, Nick was appointed Senior Vice President and General Manager of a new Intel organization, the Network and Edge Group. We begin with Nick, talking about the sheer scale of data-center traffic.

10 Dec 202124min

What are network effects? [1:32]How do you cold start and get your first users? [2:33]Atomic networks and why minimum viable community is more important than minimum viable product [6:36]How do you curate your network and set norms? [8:42]Faking users: good idea, bad idea? [13:13]What is flintstoning? [14:26]How does the relationship to creators change as you scale? [17:07]Building for the professional creator class [22:52]How is web3 changing incentives? [25:12]

6 Dec 202131min

Given all the activity and interest recently around crypto and web3, as well as in upcoming holidays and art events, we’re re-running our episode all about NFTs (from March 2021) -- where we covered everything you need or want to know about NFTs. You can also find a curated list of resources to learn all about NFTs at future.com/nftcanon. That list, and this episode, has something for everyone -- from artists and creators and other builders to big companies and institutions or just anyone seeking to understand or even explain to others NFTs.Here, we’ve cut through the noise around NFTs to share the signal, covering everything from: what NFTs are and the underlying crypto big picture, before we dig into specifically what forms they take;common myths and misconceptions -- from confusing overlaps with other concepts to addressing commentary like it’s “just a JPG” or that it’s just hypeto the question of energy use, also covering briefly how NFTs workproviding a quick overview of the players/ ecosystemand throughout, covering various applications too.Joining host Sonal Chokshi are Jesse Walden, now of Variant Fund, and formerly co-founder of Mediachain Labs, which was acquired by Spotify; and Linda Xie, now of Scalar Capital, and formerly an early product manager at Coinbase. As a reminder, NONE of the following should be taken as investment advice, for more important information please see a16z.com/disclosures.[If you’re also interested in DAOs (which we touch on briefly in this episode), we just recently published a list of readings -- in the vein of our famous crypto canon resource, then NFT canon, and now DAO canon -- all about DAOs. It’s for anyone seeking to understand, build, and otherwise get involved with these “decentralized autonomous organizations” -- which represent the future of community, coordination, work, and much more… so we’ve curated resources on this list for people at different levels of interest, from dipping one’s toes in to going deep. You can find that at future.com/daocanon.]This episode was originally released in March 2021: https://future.a16z.com/podcasts/nfts-explainer/

25 Nov 202156min