The Story of Schizophrenia
a16z Podcast7 Apr 2020

The Story of Schizophrenia

Descriptions of the mental illness we today call schizophrenia are as old as humankind itself. And more than likely, we are are all familiar with this disease in some way, as it touches 1% of us—millions of lives—and of course, their families. In this episode, we dive into the remarkable story of one such American family, the Galvins: Mimi, Don, and their 12 children, 6 of whom were afflicted with schizophrenia.

In his new book, Hidden Valley Road: Inside the Mind of an American Family, Robert Kolker follows the family from the 1950s to today, through, he writes, "the eras of institutionalization and shock therapy, the debates between psycho-therapy versus medication, the needle-in-a-haystack search for genetic markers for the disease, and the profound disagreements about the cause and origin of the illness itself." Because of that, this is really more than just a portrait of one family; it’s a portrait of how we have struggled over the last decades to understand this mysterious and devastating mental illness: the biology of it, the drivers, the behaviors and pathology, the genomics, and of course the search for treatments that might help, from lobotomies to ECT to thorazine.

Also joining Robert Kolker and a16z's Hanne Tidnam in this conversation is Stefan McDonough, Executive Director of Genetics at Pfizer World R&D, one of the genetic researchers who worked closely with the Galvins. The conversation follows the key moments where our understanding of this disease began to shift, especially with new technologies and the advent of the Human Genome Project—and finally where we are today, and where our next big break might come from.

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a16z Podcast: China and Tech

a16z Podcast: China and Tech

China has been a tough market to crack for U.S. internet companies. One of the key reasons is China has its own crop of hugely successful and highly innovative companies. Andreessen Horowitz’s Chris Dixon, Connie Chan and Benedict Evans highlight the key players in China, and what non-Chinese companies can learn from them. Where Chinese companies and money are headed next.

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a16z Podcast: Oculus and the (Mind-Blowing) Reality of Virtual Reality

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Up until now virtual reality has been a disappointment for all those people pining for their own personal holodeck. But advances in the components required to create a truly immersive digital 3D experience have finally broken through much of what has been holding virtual reality back. As a consequence, Oculus VR is building something that is nothing short of a new medium. Andreessen Horowitz’s Chris Dixon, Balaji Srinivasan and Gil Shafir discuss the present and future potential of virtual reality. Take heart, the holodeck can’t be far away now.

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a16z Podcast: The Rise of Full Stack Startups

a16z Podcast: The Rise of Full Stack Startups

Suppose you develop a new technology that is valuable to some industry. The old approach was to sell or license your technology to the existing companies in that industry. The new approach is to build a complete, end-to-end product or service that bypasses existing companies. Andreessen Horowitz’s Chris Dixon, Balaji Srinivasan and Benedict Evans discuss the reasons behind, and advantages of, going “full stack.”

27 Mars 201418min

a16z Podcast: Searching for Mobile’s Own PageRank

a16z Podcast: Searching for Mobile’s Own PageRank

The mobile experience is still in its 1995 Yahoo phase, a sea of apps and websites without an easy way to find what you want and need on your smartphone. What will be mobile’s version of PageRank, the algorithm that made the web manageable? What is the interaction model and the form - app, card, URL – that will help us find, explore and engage with people, products and services from our mobile devices? Andreessen Horowitz’s Chris Dixon, Benedict Evans and Balaji Srinivasan delve into the options.

24 Mars 201412min

a16z Podcast: Where is the Technology That "Matters?" Right Here

a16z Podcast: Where is the Technology That "Matters?" Right Here

There is a recurring theme that the tech industry is busy cranking out fluffy social apps rather than hardcore technology. Not the case, say Chris Dixon, Benedict Evans and Balaji Srinivasan. Not only are tech entrepreneurs going after the deficiencies in healthcare, transportation, finance, energy - you name it - with new approaches riding on top of sophisticated technologies, what looks like fluff today often wields some serious influence tomorrow.

21 Mars 201414min

a16z Podcast: The State of the Bitcoin Ecosystem, and a Theory on Satoshi

a16z Podcast: The State of the Bitcoin Ecosystem, and a Theory on Satoshi

Andreessen Horowitz's Chris Dixon and Balaji Srinivasan discuss the state of the Bitcoin ecosystem now that the Mt. Gox dust has settled. What's next in crypto-currency, and a theory on Bitcoin creator Satoshi (not Dorian) Nakamoto.

20 Mars 201415min

a16z Podcast: Apple and Google Won the Mobile OS War, But a New War Has Already Begun

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Apple and Google won the mobile OS war, but the next war – to build big businesses on top of Android and iOS – is just beginning. Andreessen Horowitz Partner Benedict Evans untangles what the next phase of mobile means for entrepreneurs, Apple and Google's competitors, and consumers eager for the next great gadget.

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