World’s Largest Supercomputer v. Biology’s Toughest Problems
a16z Podcast14 Juni 2020

World’s Largest Supercomputer v. Biology’s Toughest Problems

Proteins are molecular machines that must first assemble themselves to function. But how does a protein, which is produced as a linear string of amino acids, assume the complex three-dimensional structure needed to carry out its job?

That's where Folding at Home comes in. Folding at Home is a sophisticated computer program that simulates the way atoms push and pull on each other, applied to the problem of protein dynamics, aka "folding". These simulations help researchers understand protein function and to design drugs and antibodies to target them. Folding at Home is currently studying key proteins from the virus that causes COVID-19 to help therapeutic development.

Given the extreme complexity of these simulations, they require an astronomical amount of compute power. Folding at Hold solves this problem with a distributed computing framework: it breaks up the calculations in the smaller pieces that can be run on independent computers. Users of Folding at Home - millions of them today - donate the spare compute power on their PCs to help run these simulations. This aggregate compute power represents the largest super computer in the world: currently 2.4 exaFLOPS!

Folding at Home was launched 20 years ago this summer in the lab of Vijay Pande at Stanford. In this episode, Vijay (now a general partner at a16z) is joined by his former student and current director of Folding at Home, Greg Bowman, an associate professor at Washington University in St. Louis, and Lauren Richardson. We discuss the origins of the Folding at Home project along with its connection to SETI@Home and Napster; also the scientific and technical advances needed to solve the complex protein folding and distributed computing problems; and importantly what does understanding protein dynamics actually achieve?

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a16z Podcast: Oculus and the (Mind-Blowing) Reality of Virtual Reality

a16z Podcast: Oculus and the (Mind-Blowing) Reality of Virtual Reality

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a16z Podcast: The Rise of Full Stack Startups

a16z Podcast: The Rise of Full Stack Startups

Suppose you develop a new technology that is valuable to some industry. The old approach was to sell or license your technology to the existing companies in that industry. The new approach is to build a complete, end-to-end product or service that bypasses existing companies. Andreessen Horowitz’s Chris Dixon, Balaji Srinivasan and Benedict Evans discuss the reasons behind, and advantages of, going “full stack.”

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The mobile experience is still in its 1995 Yahoo phase, a sea of apps and websites without an easy way to find what you want and need on your smartphone. What will be mobile’s version of PageRank, the algorithm that made the web manageable? What is the interaction model and the form - app, card, URL – that will help us find, explore and engage with people, products and services from our mobile devices? Andreessen Horowitz’s Chris Dixon, Benedict Evans and Balaji Srinivasan delve into the options.

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a16z Podcast: Where is the Technology That "Matters?" Right Here

a16z Podcast: Where is the Technology That "Matters?" Right Here

There is a recurring theme that the tech industry is busy cranking out fluffy social apps rather than hardcore technology. Not the case, say Chris Dixon, Benedict Evans and Balaji Srinivasan. Not only are tech entrepreneurs going after the deficiencies in healthcare, transportation, finance, energy - you name it - with new approaches riding on top of sophisticated technologies, what looks like fluff today often wields some serious influence tomorrow.

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a16z Podcast: The State of the Bitcoin Ecosystem, and a Theory on Satoshi

a16z Podcast: The State of the Bitcoin Ecosystem, and a Theory on Satoshi

Andreessen Horowitz's Chris Dixon and Balaji Srinivasan discuss the state of the Bitcoin ecosystem now that the Mt. Gox dust has settled. What's next in crypto-currency, and a theory on Bitcoin creator Satoshi (not Dorian) Nakamoto.

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a16z Podcast: Apple and Google Won the Mobile OS War, But a New War Has Already Begun

a16z Podcast: Apple and Google Won the Mobile OS War, But a New War Has Already Begun

Apple and Google won the mobile OS war, but the next war – to build big businesses on top of Android and iOS – is just beginning. Andreessen Horowitz Partner Benedict Evans untangles what the next phase of mobile means for entrepreneurs, Apple and Google's competitors, and consumers eager for the next great gadget.

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