Psychedelics to manage opioid use with Noa Krawczyk

Psychedelics to manage opioid use with Noa Krawczyk

In this episode, Dr Elle Wadsworth talks to Dr Noa Krawczyk from the Department of Population Health at NYU Grossman School of Medicine about her and her co-authors research report on self-reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities. Noa discusses the current treatments available for opioid use disorder and why psychedelics are having their moment as an alternative medicine, and what people who use opioids found when taking psychedelics with the intention of reducing or stopping their opioid use.

· What is Reddit and why is Noa using it to answer her research questions [01:24]

· The headline findings of the study [02:17]

· The comparison of demographics of Reddit and the wider population of people who use opioids [03:46]

· What the current treatments are for opioid use disorder in the US and why people are seeking alternatives [05:22]

· Why Ibogaine stands out as a prominent psychedelic in the discussion [08:12]

· The mechanisms of action found in the analysis [09:45]

· The benefits and drawbacks of using psychedelics [13:26]

· What we can take from the paper for policy and practice [15:28]

About Elle Wadsworth: Elle is an academic fellow with the Society for the Study of Addiction. She is based at the University of Bath and her research interests include drug policy, cannabis legalisation, and public health. Elle is also a senior analyst at RAND Europe, working on projects focusing on national and international drug policies.

About Noa Krawczyk: Noa Krawczyk, PhD, is an assistant professor in the Department of Population Health at NYU Grossman School of Medicine and Associate Director of the NYU Langone Center for Opioid Epidemiology and Policy. Her research focuses on studying ways to address barriers to evidence-based treatment for opioid use disorder at the individual, program, and policy levels. Her work centers on bridging research and practice by collaborating with drug user organizations, health system leaders, public health and government agencies, and advancing science that can help inform evidence-based policies and practices that reduce harm and promote well being.

About co-author Megan Miller: Megan Miller, MPH, is a Research Coordinator in the Center for Opioid Epidemiology and Policy at NYU Grossman School of Medicine and served as the primary data analyst for the Reddit study. She holds an MPH from the University of North Carolina at Chapel Hill.

NK receives fees as an expert witness in ongoing opioid litigation. MM has no conflicts of interest to declare.

Original article: Self-reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities https://doi.org/10.1111/add.16767

The opinions expressed in this podcast reflect the views of the host and interviewees and do not necessarily represent the opinions or official positions of the SSA or Addiction journal. The SSA does not endorse or guarantee the accuracy of the information in external sources or links and accepts no responsibility or liability for any consequences arising from the use of such information.

Hosted on Acast. See acast.com/privacy for more information.

Avsnitt(98)

Gambling, risk-taking and alcohol with Tori Horn

Gambling, risk-taking and alcohol with Tori Horn

In this episode, Tori Horn from the University of Memphis talks about her recent systematic review of risk-taking and gambling whilst drinking.Tori talks about the moderators between alcohol and risk-taking and how her and her colleagues screened 30,000 papers to examine the influence of blood alcohol concentration, gender, the type of gambling and other factors as potential moderators of this relationship.“We thought perhaps that, what’s influencing this is the expectancies, and the vast majority of studies included used the placebo design […] which led us to conclude that maybe people are expecting, once they’re told they’re consuming alcohol, that their behaviour’s going to be different.” Tori talks about the different ways that risk-taking is measured in studies, including inflating balloons until they burst for a cash pay-out. She also explores the problems with lab designs and the challenge of translating research into naturalistic settings. Original research article: Does acute alcohol consumption increase risk-taking while gambling? A systematic review and meta-analysis. By Tori Horn and colleagues. Published in Addiction (2022). Hosted on Acast. See acast.com/privacy for more information.

15 Juni 202216min

Brief interventions, emergency departments, and alcohol with Paolo Deluca

Brief interventions, emergency departments, and alcohol with Paolo Deluca

In this episode of the Addiction Audio podcast, Dr Paolo Deluca talks about his recent research on using brief interventions in emergency departments.The research involved a three-armed randomised controlled trial on brief interventions for young people, and found no significant differences in alcohol-related outcomes between young people who had been given a brief intervention and those who had not. In the podcast, Paolo reflects on some of the potential reasons for this, considering previous evidence in support of brief interventions.“When you move away from an efficacy trial or a single site study where you have highly trained professionals or practitioners delivering the interventions and you move into the real-world NHS setting is where you tend to lose some of the effectiveness you might have had in the early stages of the brief intervention.”Paolo also talks about the core components of brief interventions that can be delivered in 10 minutes in busy emergency departments, and discusses some of the logistical and ethical challenges of recruiting young people to a three-armed trial.“We involved 10 emergency departments, and we ran it for around 8 months and were recruiting from 10am to 10pm in the afternoon and we were covering 7 days a week. To achieve that we had essentially an army of researchers.”Original article: Effectiveness and cost-effectiveness of face-to-face and electronic brief interventions versus screening alone to reduce alcohol consumption among high risk adolescents presenting to Emergency Departments: three-arm pragmatic randomised trial (SIPS Junior High Risk Trial). By Paolo Deluca and colleagues. Published in Addiction (2022). Hosted on Acast. See acast.com/privacy for more information.

8 Juni 202223min

Drug checking services with Nazlee Maghsoudi

Drug checking services with Nazlee Maghsoudi

In this episode of Addiction Audio, Nazlee Maghsoudi talks about her recent publication “Drug checking services for people who use drugs: a systematic review”. Nazlee discusses how drug checking services change behaviour, contribute to drug market monitoring and otherwise impact the risk associated with using substances. She talks about the three waves of drug checking services from the late 1960s to present day. Nazlee talks about the benefits of working with library sciences experts when setting the search parameters for her systematic review. She also talks about how important it is for physicians or GPs to know what substances people might have taken. “We know from the systematic review [people who use drug checking services] do make changes in their behaviour, they do take that information into account, and whether it’s choosing to not use, choosing to use less, choosing to seek more information before they use, that gives them information to make more informed choices about the drugs they use.” Nazlee is the Manager of the Policy Impact Unit at the Centre on Drug Policy Evaluation in Toronto, and a PhD Candidate in Health Services Research at the Institute of Health Policy, Management and Evaluation within the University of Toronto.Original research article: Drug checking services for people who use drugs: a systematic review By Nazlee Maghsoudi and colleagues. Published in Addiction (2021) Hosted on Acast. See acast.com/privacy for more information.

7 Apr 202224min

Drinking patterns during lockdown with Iain Hardie

Drinking patterns during lockdown with Iain Hardie

Dr Iain Hardie talks to Addiction Audio about his research into alcohol use changes during lockdown. His research is the first to report longitudinal data on changes in drinking quantities and characteristics. Dr Hardie talks about using an interrupted time series analysis to identify the impact of the pandemic on drinking habits. “A lot of [drinking] occasions in general that start earlier in the day are quite often people meeting up for long drinking occasions or big social occasions that last the whole day, whereas when lockdowns were in place those occasions weren’t possible so people were drinking later on in the day” Iain discusses how Scotland and England differ in the numbers of people who drink alone and talks about the potential long-term consequences resulting from changes in drinking patters whereby more people currently drink at home and fewer go out to pubs and bars. Hosted on Acast. See acast.com/privacy for more information.

23 Mars 202216min

Pre-registration with John Marsden

Pre-registration with John Marsden

In this episode of Addiction Audio, Professor John Marsden talks about the role of pre-registration in increasing research transparency. He addresses the anxieties that people can have about pre-registration and talks about how it’s really not that difficult or daunting.Professor Marsden talks gets into the detail of pre-registration; when to register, how to register and the importance of planning for – and dealing with – missing data. He covers how plans change during any research project and how to respond when they do. The importance of pre-registration also includes qualitative research and Professor Marsden talks about the need for more qualitative and observational studies to be pre-registered.“We’re really trying to encourage people to just plan, adapt if you need to, change if you have to – but just have a clear narrative about that – and everyone benefits. It means that what was done is much more reproducible.”Professor John Marsden is the Editor-in-Chief of the journal Addiction. He is Professor of Addiction psychology at the Addictions Department, the Institute of Psychiatry, Psychology and Neuroscience, Kings College London.Marsden, J, Cousijn, J and Stapleton, J, Pre‐registration: not a daunting practice. Addiction. 2022. https://doi.org/10.1111/add.15819 Hosted on Acast. See acast.com/privacy for more information.

16 Mars 202229min

ADHD and maternal substance use with Elis Haan

ADHD and maternal substance use with Elis Haan

Dr Elis Haan talks to Dr Rob Calder about ADHD and maternal substance use. She discusses her recent paper which explored the impact of smoking, alcohol and drugs during pregnancy on ADHD outcomes in young people.Elis talks about the differences between maternal and teacher ratings of ADHD. She also explains negative control and polygenic risk score methods used in this study discussing how multiple methods were used across different longitudinal datasets to add confidence to their analysis. “Combining these different methods can help to gain stronger support for a causal effect…. For example, if these different methods and analyses across these cohorts provide similar results we can be more confident that the results reflect a true causal effect. This is because it is unlikely that these different methods will be all biased in the same way”Haan E, Sallis HM, Zuccolo L,Labrecque J, Ystrom E, Reichborn-Kjennerud T, et al. Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses. Addiction. 2021;1–14. https://doi.org/10.1111/add.15746. Hosted on Acast. See acast.com/privacy for more information.

28 Feb 202217min

JITAIs and using smartphones to prevent lapse with Olga Perskie

JITAIs and using smartphones to prevent lapse with Olga Perskie

Rob Calder talks to Dr Olga Perski about her recent research on just-in-time adaptive interventions (JITAIs) whereby smartphones are used to help prevent lapses among people who are trying to quit or reduce alcohol, tobacco or other drug use. Dr Perski talks about why the literature is so complex and how defining JITAIs is difficult in the first place. She talks about the potential for Ecological Momentary Assessment (EMA), GPS positioning and micro-randomised trial studies to contribute in this area, and how we may not want to press ahead with full-scale RCTs before having conducted additional conceptual and computational work to clarify what JITAIs are and how to develop them. Dr Perski also discusses the challenges of regulating mobile health apps so that people can access apps based on evidence of effectiveness. This episode was recorded online on 30 September 2021.Perski, O., Hébert, E.T., Naughton, F., Hekler, E.B., Brown, J. and Businelle, M.S. Technology‐mediated just‐in‐time adaptive interventions (JITAIs) to reduce harmful substance use: A systematic review. Addiction 2021; doi:10.1111/add.15687 Hosted on Acast. See acast.com/privacy for more information.

27 Okt 202130min

Mental imagery and cocaine craving with John Marsden

Mental imagery and cocaine craving with John Marsden

Rob Calder talks to Professor John Marsden about cocaine cravings. Professor Marsden discusses the lack of pharmacological treatments for cocaine, and about his recent study using mental imagery to address cocaine cravings. He talks about the benefits of positive imagery compared with negative imagery. He then discusses how useful mixed-methods research can be and the importance of writing up data from unfinished trials. Lowry, N., Marsden, J., Clydesdale, B., Eastwood, B., Havelka, E.M. and Goetz, C. Acute impact of self‐guided mental imagery on craving in cocaine use disorder: a mixed‐methods analysis of a randomized controlled trial. Addiction 2021; doi:10.1111/add.15405https://onlinelibrary.wiley.com/doi/full/10.1111/add.15405 Hosted on Acast. See acast.com/privacy for more information.

20 Okt 202131min

Populärt inom Vetenskap

p3-dystopia
svd-nyhetsartiklar
allt-du-velat-veta
dumma-manniskor
kapitalet-en-podd-om-ekonomi
det-morka-psyket
ufo-sverige
rss-i-hjarnan-pa-louise-epstein
rss-ufo-bortom-rimligt-tvivel--2
rss-vetenskapsradion-2
rss-vetenskapsradion
bildningspodden
medicinvetarna
vetenskapsradion
hacka-livet
sexet
a-kursen
ufo-sverige-2
paranormalt-med-caroline-giertz
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli