2024 Big Ideas: Miracle Drugs, Programmable Medicine, and AI Interpretability
Smart energy grids. Voice-first companion apps. Programmable medicines. AI tools for kids. We asked over 40 partners across a16z to preview one big ideathey believe will drive innovation in 2024.Here in our 3-part series, you’ll hear directly from partners across all our verticals, as we dive even more deeply into these ideas. What’s the why now? Who is already building in these spaces? What opportunities and challenges are on the horizon? And how can you get involved?View all 40+ big ideas: https://a16z.com/bigideas2024 Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
8 Dec 20231h 5min
The Quest for AGI: Q*, Self-Play, and Synthetic Data
One topic at the center of the AI universe this week is a potential breakthrough called Q*. Little has been revealed about this OpenAI project, other than its likely relationship to solving certain grade-school mathematical problems.Amid much speculation, we decided to bring in our new general partner, Anjney Midha – focused on all things AI – to sift through the sea of noise.Today, we discuss the key frontier research areas that AI labs are exploring on their path toward generalizable intelligence, from self-play, to model-free reinforcement learning to synthetic data. Anjney also shares his insights on which approach he expects to be most influential in the next wave of LLMs and why math problems are even a suitable testing ground for this kind of research. Topics Covered:02:03 - What is Q*?06:21 - Applying model-free reinforcement learning to complex spaces13:17 - The role of self-play19:04 - Synthetic data’s big unlock24:44 - What does this unlock for society? Resources:Follow Anjney on Twitter: https://twitter.com/AnjneyMidha Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
4 Dec 202326min
Financial Freedom, Company Building, More with David Marcus
with @davidmarcus @smc90This wide-ranging conversation covers company building, big to small -- including what cadence and when is the right "time" to ship; the relationship between centralization, decentralization, platforms, and financial freedom; moving from web2 to web3 in both crypto AND payments... as well as why bitcoin, views on remote work, and much much more. Our guest is David Marcus, CEO and co-founder of Lightspark; Marcus was also a co-creator of Diem (aka Libra and Novi, the cryptocurrency project initiated by Facebook). Before that, he was vice president of messaging products there, where he ran the Facebook Messenger unit; and prior to joining Facebook, Marcus was the former president of PayPal (which had acquired his previous startup). This episode begins with an interview just to help kick things off and then features a rich set of questions from the audience -- as this originally took place live on stage at our Crypto Startup School 2023. As a reminder: none of this should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.related readings:Regulate apps, not protocols series (2022-2023) - Miles Jennings et al, a16z crypto)What it will take to create the next great Silicon Valleys (2014) - Marc Andreessen (Politico, a16z)Why bitcoin matters (2014) - Marc Andreeessen (NYT, a16z)When one app rules them all: The case of WeChat and Mobile in China (2015) - Connie Chan (a16z) Subscribe to web3 with a16z: https://link.chtbl.com/web3witha16z Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
28 Nov 202348min
When Business is Battle: Inside the Boardrooms of the CEOs that Survived the Storm
Taking a company from idea to household name is always difficult. But the past few years presented challenges that caught even the most-seasoned CEOs off guard.In this episode, you’ll hear from two CEOs that navigated these waters and somehow, came out on the other side. These recordings come straight from our exclusive Connect/Enterprise event, bringing together top executives across the a16z network. Resources:Additional content from Connect/Enteprise:Enterprise Startups: Advice on Hiring, Firing, Scaling, and SellingBuilding Products With Generative AI Learn more about company-building: https://a16z.com/category/company-building/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
23 Nov 202351min
The Worlds She Sees with Godmother of AI, Fei-Fei Li
Fei-Fei Li, PhD, Professor in the Computer Science Department at Stanford University, and Co-Director of Stanford’s Human-Centered AI Institute, joins Bio + Health founding partner Vijay Pande.In this candid conversation, Li unfolds her transformation from a young immigrant to an influential figure in AI. The conversation explores the birth of ImageNet, a pivotal step that bridged the gap between visual intelligence and accessible AI technology. They delve into the notion of a 'Dignity Economy,' hinting at a future where technology serves to elevate human experience rather than undermine it. Li also touches on the delicate balance between relentless innovation and life's humble pursuits. This episode peels back the layers on the human side of AI, offering a rare glimpse into the personal and professional realms of a pioneer shaping the AI landscape.Check out her new book, The Worlds I See, here: https://us.macmillan.com/books/9781250897930/theworldsiseeCheck out other episodes form our sister podcast, Bio Eats World: https://a16z.com/podcasts/bio-eats-world/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
13 Nov 202328min
From Sims to Sapiens: Crafting Reality with Code
Is it possible to construct a virtual society that authentically replicates human behavior? AI Town, a virtual town experiment where AI residents live, interact, and engage, provides valuable insights into the future of AI's believability and its interaction with humanity.In this panel discussion, Joon Park, the author of 'Generative Agents: Interactive Simulacra of Human Behavior,' and Martin Casado from a16z, discuss the influence and potential of Generative Agents, exploring their practical applications in the real world.Topics Covered00:00 - Simulating human behaviors04:49 - What are generative agents?07:47 - Simulations, new technology, and LLMs11:45 - The architecture behind simulating human behavior16:37 - Generative agents interactions: observing, planning, and reflecting20:22 - What is the value in advancing generative agents?24:01 - Use cases for simulation behavior technology29:31 - What are the ethical frameworks?33:12 - Q&A from the audience Resources: Find AI Town: https://www.convex.dev/ai-townRead the paper ‘Generative Agents: Interactive Simulacra of Human Behavior’: https://arxiv.org/pdf/2304.03442.pdfFind Joon on Twitter: https://twitter.com/joon_s_pkFind Martin on Twitter: https://twitter.com/martin_casadoFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
6 Nov 202339min
Fintech Fuels Global Payments
Software crosses borders effortlessly. The globalization of money, however, is considerably more challenging. This is especially true for multinational businesses, which grapple with managing multiple accounts in diverse currencies, navigating costly foreign exchange rates, and unpredictable money transfers.As businesses increasingly embrace a global default, top fintech entrepreneurs are rising to the challenge, addressing cross-border infrastructure issues and offering comprehensive solutions.In this episode, a16z partners Angela Strange, Joe Schmidt, and Gabriel Vasquez discuss the challenges of cross-border payment infrastructures and what fintech entrepreneurs are doing to create a more integrated, financially inclusive world.Topics Covered:00:00 - Software crosses borders easily; money does not. 03:02 - Why has global payments been a challenge for so long? 05:44 - How global payments and money currently moves07:25 - The metrics used to measure a country's financial health12:13 - The impact of regulation on financial services16:23 - Can the same regulations be applied to any country? 21:29 - Why each country has its own fintech system24:54 - Opportunities in global payments infrastructure34:47 - Advice for founders navigating global fintech systems36:58 - What does a truly global system enable? Read the Fintech Fuels Global Payments package: https://a16z.com/global-paymentsWatch ’Foreign Exchange 101: What Happens When You Send Money Abroad?’: https://youtu.be/eoXdyO9oGJc?feature=sharedFind Angela on Twitter: https://twitter.com/astrangeFind Joe Schmidt on Twitter: https://twitter.com/joeschmidtivFInd Gabriel Vasquez on Twitter: https://twitter.com/GEVS94Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
30 Okt 202339min
The Techno-Optimist Manifesto with Marc Andreessen and Ben Horowitz
Subscribe to The Ben & Marc Show on Apple Podcasts: https://bit.ly/3SdsfNtSubscribe to The Ben & Marc Show on Spotify: https://spoti.fi/3SclPOrRead the full manifesto: https://a16z.com/the-techno-optimist-manifesto/ This past week, Marc released his new vision for the future – “The Techno-Optimist Manifesto”.In an article that has sparked widespread conversation across traditional and social media, Marc challenges the pessimistic narrative surrounding technology today, and instead celebrates it as a liberating force that can lead to growth, progress and abundance for all. In this one-on-one conversation based on YOUR questions from X (formerly Twitter), Ben and Marc discuss how technological advancements can improve the quality of human life, uplift marginalized communities, and even encourage us to answer the bigger questions of the universe.We hope you’ll be inspired to join us in this Techno-Optimist movement. Enjoy! Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
25 Okt 20231h 7min
