Marc Andreessen & Jack Altman: Venture Capital, AI, & Media

It's been nearly 15 years since the Human Genome Project was completed. But "are we there yet" in the golden age of genomics? What did we think we'd have by now, what do we actually have, and what do we really still need to make genomics live up to its promise? Well, one thing we now understand is that our DNA isn't static; in fact, it changes at an absolutely crazy rate. We also need to add more context -- about mutations, about somatic tissue, about phenotypes, about each person's unique history -- to make genetic information more complete and accurate. So what does that mean for predictive vs. diagnostic (which are two very different things) genomics? What are the challenges and opportunities for commercialization? The guests in this episode of the a16z Podcast -- Carlos Araya of Jungla,Jeff Kaditz of Q, and Gabe Otte of Freenome -- discuss all this and more with a16z bio fund partner Malinka Walaliyadde in a conversation that took place at our inaugural a16z Summit event.

22 Feb 201725min

The hardest thing about pivots (major shifts in company/product direction) isn't just the actual pivot. It's the courage to make the decision... and being honest with yourself as a CEO. Especially since, no matter how great the team or board or even customers may be, it's lonely: You're the only one in the position to synthesize the knowledge; nobody else has the data and the insight put together in the same way. And sigh, "pivot" has also become such an overused word, it's certainly lost nuance, and perhaps even meaning. So what does "pivoting" a startup really mean? For decision making? Timing (or time left until you run out of cash)? Culture? Are things different for so-called “hard tech” or deep research-based startups? Finally, how do you know when things are working, that you really do have product-market fit? a16z co-founder Ben Horowitz and Lytro CEO Jason Rosenthal discuss (in conversation with Sonal Chokshi) all this and more in this episode of the a16z podcast, sharing war stories and lessons learned. Both witnessed first-hand -- and drove -- pivots: Jason watching Ben at Loudcloud/Opsware post-IPO, and conversely, Ben watching Jason at Lytro. Maybe, all startups -- and ultimately, successful companies -- are really just a series of pivots...

19 Feb 201732min

The modern enterprise holds all sorts of applications, devices, and workflow needs. How should we be thinking about securing infrastructure -- and identity -- in this context, for entities like major news media outlets or financial institutions such as News Corp or NASDAQ? Well, this episode of the a16z Podcast brings those voices together: Frederic Kerrest, cofounder and COO of Okta; Brad Peterson, CIO of NASDAQ; and Dominic Shine, CIO of News Corp ... in conversation with Ben Horowitz at our recent a16z Summit. What's the big security picture for these types of organizations, and others? How should we prepare? Last year's DINE DDoS attack was just one glimpse of what's to come, providing a bit of a barometer read for what's currently working, and what desperately needs re-engineering. One interesting solution involves decentralization; but as we move towards such technology (like blockchain) in security, what will high-frequency trading look like? How will consumer relationships, transactions, UI/design security be reimagined? What areas and fundamentals should we focus on?

14 Feb 201719min

Thanks to freeways, cities became something to get through instead of something to get to. Now, as the next transportation revolution -- from rivers to trains to cars to autonomous cars -- promises to change the face of our cities, what happens to car culture, infrastructure, and more? Who owns what, who pays? And what about the design -- and product management -- challenges, whether it's designing for user trust, city adoption, or an ever-moving target thanks to constantly evolving tech? This episode of the podcast (in conversation with Sonal) covers all this and more, featuring: a16z's Frank Chen, who recently shared 16 questions about autonomous cars; Taggart Matthiesen, director of product at Lyft who covers the core platform as well as development/strategy for autonomous vehicles; and Carl Pope, former executive director and chairman of the Sierra Club -- and author (with former NYC mayor Mike Bloomberg) of the upcoming book Climate of Hope: How Cities Businesses and Citizens Can Save the Planet. Will curb space be the new shelf space? When we value the "iPhone-ness" over the "carness" of cars, what changes? And... will we all drive less, walk more?

8 Feb 201735min

In the age of the internet -- where information is freely available online, and connections between sellers and buyers of software products are visible on LinkedIn -- do analysts really matter? Do they play a role in decision-making for purchases from smaller vendors like tech startups, especially given the rise of the developer as a buyer? Or what if you're trying to create a new category ... do you need to be on a Gartner Magic Quadrant or Forrester Wave or similar? We answer these questions and more in this episode of the a16z Podcast, featuring former analysts, client managers, and/or product marketing veterans Stacy D'Amico (who joined a16z after a decade at Gartner), Michael King (director of enterprise product marketing at GitHub), and Aneel Lakhani, in conversation with Sharon Chang of the a16z market development team. The conversation covers everything startups should know about analyst relations, from why and how and when to engage with analysts to whether to consider pay-for-play (no!) or more boutique/niche analyst firms. Most importantly: given their limited resources but big market visions, how can startups get the most out of analyst relations?

1 Feb 201731min

Once upon a time, Robert Stromberg got a phone call from "Jim" Cameron (aka James Francis Cameron of Terminator and Titanic fame) about a little project called Avatar. Before he knew it, he was responsible for designing the organic world of Pandora, from bioluminescent plants to lush mountaintops. That was when Stromberg realized how much more technology could do, when ready, for creating more such virtual worlds. He'd actually been creating such worlds for ages, from drawing monsters in childhood to doing matte art, production design, art direction, and more for films. In this episode of the a16z Podcast, the two-time Academy Award winner (for production design on Avatar and Alice in Wonderland) and director of Maleficent shares his views on the evolution of filmmaking, narrative, and virtual reality. Stromberg directed the VR gaming experience based on The Martian (which received a Cannes Silver Lion award) and co-founded The Virtual Reality Company, which is re-imagining the film studio for the next generation of tech. What challenges do we face in an immersive medium, what will narratives look like, and what new (or even retro) techniques will we need? All this and more in this episode -- along with a16z partners Kyle Russell, Hanne Tidnam, and Sonal Chokshi -- continuing our series on new medium storytelling. image: Wikimedia Commons The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

27 Jan 201738min

"Punch above your weight" -- If there's one thing public relations (PR) should help startups and founders do, it's that. Unfortunately, some companies are actually punching below their weight when there's a strong company, founder, product ... yet nobody knows about let alone talks about you. Or worse, someone else defines you first. Or you just become a hype machine. So what conversations should you be in? Is it good or bad to do PR before you have a product? And operationally, WHEN is the right time to build a PR function; WHO should you hire (whether a full-time PR person, consultant, or agency); and HOW can you tell the good from the bad? How do you even know "it's working", when time-is-money for both the startup and the PR firm that's billing you hourly or monthly? There's no easy answer, but it doesn't have to be that hard, either. In this episode of the a16z podcast, partners Margit Wennmachers and Kim Milosevich -- PR veterans who've seen all sides of public relations, from agency to big companies to startups -- share how to strike the just-right balance between doing PR too early or too late, time wasted or time wisely spent, and knowing to say "not now" vs. no... It's all about the art of persuasion. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

26 Jan 201742min

The building blocks for VR and AR are finally here -- but the content is just beginning. So everything you'll actually experience and consume in these new mediums over the next few years is being built right now. Formats aren't yet defined or locked down, and the field is bubbling up with experiments in forms, formats and genres, from narrative to games to live events. As we begin to have real time rendered characters and AI-driven environments that you can interact with, the storytelling structure will also need to completely change. Are these mediums inherently social -- or just the opposite? What will self expression look like? What experiences are being built? Because fundamentally, that is the "celluloid" we are now working with -- human experience, says Within cofounder and filmmaker Chris Milk. Bigscreen founder and CEO Darshan Shankar, Lytro CEO Jason Rosenthal, and Milk join a16z's Kyle Russell in conversation about the challenges, potential, and emotional power of these new technologies -- on this episode of the a16z Podcast, recorded at the inaugural a16z summit. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

24 Jan 201726min