Is Methotrexate ready for clinical use? A discussion with Professor Robin Christensen and Dr Anna Dossing
Joint Action20 Juli 2025

Is Methotrexate ready for clinical use? A discussion with Professor Robin Christensen and Dr Anna Dossing

Methotrexate is a well-established drug used in oncology, but could it also play a role in managing osteoarthritis? In this episode of Joint Action, Professor David Hunter is joined by Dr Anna Døssing and Professor Robin Christensen to explore the potential of methotrexate as a treatment for osteoarthritis pain.

They discuss:

  • What methotrexate is and how it works
  • Insights from a recent meta-analysis on its effectiveness and safety
  • Why individual studies show mixed results
  • Whether it might help people with hand or knee OA - especially those with signs of inflammation
  • How dosing and side effects factor into clinical decision-making

Tune in for an honest, data-driven conversation about repurposing an old drug for a new purpose - and what it could mean for people living with osteoarthritis.


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