354: How Cohesin Acetylation and ATPase Shape Chromatin Loops and Cohesion
Costantino L et al., PNAS - Costantino et al. dissect how Eco1-mediated acetylation of Smc3 (K112, K113) and cohesin ATPase activity separately regulate chromatin loop size, loop positioning, and sist...
30 Apr 14min
353: Masculinization Reverses Sex Differences in Fertility
Schubert HA et al., PNAS - This episode reviews a global analysis showing that shifts in population sex composition have reversed historical sex gaps in fertility. Using UN World Population Prospects ...
30 Apr 27min
352: Interspecies control of E. coli growth in human gut microbiomes
Boumasmoud M et al., PNAS - Reciprocal transplant experiments in anaerobic microcosms show that resident human gut microbiome context alters growth of introduced Escherichia coli strains and that micr...
27 Apr 25min
351: When Selection Survives Admixture: Hard Sweeps in Ancient Eurasians
Harris M et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study that uses a domain-adaptive neural network to detect and classify selective sweeps in over ...
26 Apr 24min
350: OPA1 A8S in Rhesus Macaques Models Autosomal Dominant Optic Atrophy
Jaggers TN et al et al., PNAS - A spontaneous OPA1 A8S missense mutation in rhesus macaques produces retinal ganglion cell loss, RNFL thinning, optic nerve atrophy, OPA1 mislocalization, and mitochond...
25 Apr 25min
349: Oxidized rNTPs and Transcription Fidelity: How 8‑oxo‑rGTP Embeds RNA Damage
Hou P et al., PNAS - This study combines kinetic assays and X‑ray crystallography to show how 8‑oxo‑guanosine triphosphate (8‑oxo‑rGTP) is incorporated by RNA polymerase II and how its pairing geometr...
24 Apr 21min
348: v96: A 96-mutation plasma DNA test to track residual AML through transplant
Wang Y et al et al., PNAS - This episode covers a PNAS study describing v96, a personalized plasma cell-free DNA assay that tracks up to 96 patient-specific mutations to sensitively quantify measurabl...
21 Apr 23min
347: Diffusive spreading across dynamic mitochondrial network architectures
Holta KB et al., Proceedings of the National Academy of Sciences (PNAS) - This episode explains a quantitative framework for diffusion on spatially embedded dynamic mitochondrial networks. The study c...
19 Apr 23min
