434: High‑coverage genomes recast Japan's prehistoric demography
Ishiya K et al., PNAS - This episode examines a PNAS study that reports two high-coverage ancient human genomes from mainland Japan (an Initial Jomon >67× and a Middle Yayoi >46×). The genomes enable ...
6 Aug 27min
433: Lactate, HSP90α and the Mitochondrial Switch
Wu G et al., Proceedings of the National Academy of Sciences - This episode examines a PNAS study that identifies site-specific lactylation of HSP90α as a metabolic signal linking glycolysis to mitoch...
23 Juli 23min
432: Echovirus 18: Capsid opening releases the genome
Mukhamedova L et al., Proceedings of the National Academy of Sciences - Using cryo-electron tomography and single-particle cryo-EM of infected Cos-7 cells, the authors show that echovirus 18 (E18) rel...
23 Juli 18min
431: KIAP4 and the ARND family: essential proteins for Leishmania–sand fly adhesion
Owino BO et al., Proceedings of the National Academy of Sciences - TurboID proximity labeling and proteomics identify KIAP4 as the canonical member of a conserved Adhesion Related NTPase-like Domain (...
23 Juli 21min
430: Proterozoic Rise: Steady Diversification of Crown Eukaryotes
Sandin MM et al., Proceedings of the National Academy of Sciences - Molecular clocks and diversification models applied to a 75,975-OTU rDNA dataset, including long-read environmental sequences and 77...
23 Juli 25min
429: Validating the EAGL genetic literacy measure
Barna LS et al., Human Genetics and Genomics Advances - We summarize a psychometric validation of the EAGL measure using US adult online samples. The study produced a validated 17-item EAGL-short that...
23 Juli 23min
428: Genetic regulation of plasma metabolites in people with HIV
Ait Oumelloul M et al., Human Genetics and Genomics Advances - Untargeted plasma metabolomics (1,930 features) in 1,244 participants of the Swiss HIV Cohort Study were paired with genome-wide genotype...
23 Juli 28min
427: When Genes Talk to Gut: Microbiome as Mediator of Metabolic Risk
Simpson RC et al., Trends in Genetics - This forum reviews evidence that host genetic variants associated with metabolic disease often overlap with loci that shape gut microbiome composition and funct...
23 Juli 25min
