51: Finding Hidden mtDNA Diagnoses in Solve-RD
Ratnaike et al et al., The American Journal of Human Genetics - This episode reviews a Solve-RD reanalysis that integrated an mtDNA-focused bioinformatic pipeline (MToolBox) with MitoPhen HPO-based ph...
21 Juni 202517min
50: Translating the Microbiome to the Clinic
Porcari S et al., Cell - Perspective reviewing current diagnostic and therapeutic advances in gut microbiome research and outlining the methodological, biological, regulatory, and educational actions ...
19 Juni 202517min
49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae
Holt JD et al., PNAS - Using microfluidic flow assays and live-cell imaging, the authors show that environmental DNA adsorbs to chitin particles and that Vibrio cholerae can retrieve this chitin-bound...
18 Juni 202522min
48: Mainstreaming Clinical Genetic Testing: A Framework for Care
Mackley MP et al., Genetics in Medicine - A consensus-driven conceptual framework from Canadian genetics experts describing four models for mainstreaming clinical genetic testing and the variables tha...
16 Juni 202516min
47: Encoding and decoding chemokine-GPCR selectivity
Kleist AB et al., Cell - A data-driven mapping of how 46 human chemokines and 23 GPCRs encode selective and promiscuous interactions. The team defines conserved, semi-conserved and variable determinan...
16 Juni 202522min
46: How tRNA modifications tune m6A-dependent mRNA decay
Linder B et al., Cell - This episode explores a pan-epitranscriptomic mechanism showing how m6A in coding sequences slows ribosomal decoding to trigger translation-dependent mRNA decay, and how the tR...
14 Juni 202520min
45: RNA-dependent mechanics of nucleolar subcompartments
Cheng HH et al., Proceedings of the National Academy of Sciences (PNAS) - Using micropipette aspiration in Xenopus laevis oocyte nuclei, authors show the nucleolar granular component behaves as a liqu...
12 Juni 202520min
44: Polε Proofreading Revealed
Wang F et al., PNAS - This episode examines a cryo-EM study that captures authentic proofreading intermediates of human Polε in complex with PCNA by generating a mismatch in situ. The work reveals how...
12 Juni 202519min
