Base by Base
Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Jaksot(462)

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore a PNAS study revealing how TMEM217 forms a complex wi...

21 Loka 202516min

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS study showing how a synthetic bottlebrush block copolyme...

20 Loka 202520min

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we explore a PNAS study showing that short, previously nongenic DNA sequ...

19 Loka 202519min

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Danchuk S et al., Proceedings of the National Academy of Sciences - Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? Music:Enjoy the music based on this article at...

18 Loka 202516min

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

Picchetta L et al., The American Journal of Human Genetics - Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans Music:Enjoy the music based on this article at the end of the episode...

17 Loka 202517min

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

Aslanzadeh V et al., Nature Communications - Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance Music:Enjoy the music based on this article at the end of...

16 Loka 202521min

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Baird D et al., Nature Communications - Low circulating miR-190a-5p predicts progression of chronic kidney disease Music:Enjoy the music based on this article at the end of the episode. Article titl...

15 Loka 202519min

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

Qu Y et al., Cell Genomics - DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution Music:Enjoy the music based on this article at the end of the episode. Article title:Single-c...

14 Loka 202521min

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