Base by Base
Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Jaksot(462)

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

Oosterheert W et al., Cell - Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments Music:Enjoy the music based on this article at the end of the episode. Article ti...

13 Loka 202513min

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Schoenle A et al., Trends in Genetics - Protist Genomics: Key to Understanding Eukaryotic Evolution Music:Enjoy the music based on this article at the end of the episode. Article title:Protist genom...

12 Loka 202519min

164: m6A in the coding sequence: linking deposition, translation, and decay

164: m6A in the coding sequence: linking deposition, translation, and decay

Ćorović M et al., Trends in Genetics - m6A in the coding sequence: linking deposition, translation, and decay Music:Enjoy the music based on this article at the end of the episode. Article title:m6A...

11 Loka 202514min

163: Animal origins: looping back in time

163: Animal origins: looping back in time

Matar O et al., Trends in Genetics - Animal origins: looping back in time Music:Enjoy the music based on this article at the end of the episode. Article title:Animal origins: looping back in time F...

10 Loka 202514min

162: Spatial miRNomics: technologies, challenges, and opportunities

162: Spatial miRNomics: technologies, challenges, and opportunities

Robles-Remacho A et al., Trends in Genetics - A concise review of emerging methods to map microRNA (miRNA) expression in tissues with spatial context, covering imaging and sequencing approaches, techn...

9 Loka 202520min

161: Decoding genomic landscapes of introgression

161: Decoding genomic landscapes of introgression

Huang X et al., Trends in Genetics - A concise review of methodological advances for identifying introgressed loci across genomes. The article surveys summary statistics, probabilistic modeling, and s...

8 Loka 202520min

160: Long reads meet single-cell omics

160: Long reads meet single-cell omics

Wen L et al., Trends in Genetics - This review surveys the integration of single-molecule long-read sequencing (SMS) with single-cell genomics, epigenomics and transcriptomics, describing platforms, m...

7 Loka 202515min

159: Short Reads, Big Biodiversity: The Untapped Potential of Genome Skimming

159: Short Reads, Big Biodiversity: The Untapped Potential of Genome Skimming

Bleidorn C et al., Trends in Genetics - This episode examines a Trends in Genetics review arguing that short-read shotgun sequencing and genome skimming remain powerful, cost-effective tools for biodi...

6 Loka 202515min

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