110: Rare coding variants implicate STAG1 and ZNF136 in schizophrenia
Chick SL et al et al., Nature Communications - Largest exome-sequencing meta-analysis to date (28,898 cases, 103,041 controls, 3,444 trios) identifies STAG1 and ZNF136 at exome-wide significance and s...
18 Elo 202520min
109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality
️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA editor ADAR1 becomes lethal to BRCA1/2‑mutant c...
17 Elo 202518min
108: Epigenome Editing Reverses HBG Silencing
Bell HW et al et al., Nature Communications - This study shows that CpG methylation at proximal HBG promoters causally enforces perinatal silencing and that targeted epigenome editing can reverse that...
16 Elo 202520min
107: Host genetics of endodontic infections: FinnGen GWAS
Salminen A et al., Nature Communications - A large GWAS in 485,230 FinnGen participants (132,124 cases) identified genetic loci associated with pulpal and apical diseases. The study highlights strong ...
15 Elo 202519min
106: Decoding Cortical Transcriptomes: GABAA Subunit Classes and Pharmacotranscriptomics
Ecker C et al., Nature Communications - This episode reviews a study that develops a surface-based, vertex-level framework for genome-wide imaging transcriptomics using spatial interpolation of the Al...
14 Elo 202519min
105: When Tumors Go Neutral: Genome-Level Selection and Resistance
Persi E et al., Nature Communications - This episode unpacks a multi-cohort study showing that tumors evolving toward neutral genome-level selection (dN/dS ≈ 1) during or after therapy are associated ...
13 Elo 202518min
104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation
Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base ...
12 Elo 202516min
103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery
Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no spon...
11 Elo 202517min
