Base by Base
Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

Tämä podcast on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi podcastin jaksot saattavat sisältää mainontaa.

Jaksot(462)

102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no...

10 Elo 202514min

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no sponsors, no pa...

9 Elo 202518min

100: ALMA: Epigenomic diagnosis & prognosis of AML

100: ALMA: Epigenomic diagnosis & prognosis of AML

Marchi F et al., Nature Communications - This study builds the Acute Leukemia Methylome Atlas (ALMA) from 3,314 patient methylomes and presents three models—ALMA Subtype, AML Epigenomic Risk, and a 38...

8 Elo 202514min

99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

Dicke A-K et al., Nature Communications - Proteomics, molecular and genetic analyses identify NXT2 as the predominant NXT protein in the human testis that binds NXF1, NXF2 and NXF3 and associates with...

7 Elo 202514min

98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

Busarello E et al., Nature Communications - This episode covers the Cell Marker Accordion, an integrated marker database plus R package and Shiny app that weights marker genes by specificity and evide...

6 Elo 202519min

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole genome and transcriptome sequencing uncovers clinic...

5 Elo 202521min

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore a large-scale proteomic study comparing cerebro...

4 Elo 202516min

95: Mitochondria transfer: biotech strategies and clinical hurdles

95: Mitochondria transfer: biotech strategies and clinical hurdles

Kubat GB et al., Nature Communications - This Perspective surveys recent biotechnological advances that enhance mitochondria transfer and transplantation (MTT) — including surface functionalization, e...

3 Elo 202519min

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