#118 - A Sleep Medication to Lower the Risk of Alzheimer's

#118 - A Sleep Medication to Lower the Risk of Alzheimer's

Matt examines the critical link between sleep quality and Alzheimer’s pathology. He details the brain's "night shift" - the glymphatic system - which actively flushes out toxins like amyloid beta during deep sleep. Listeners learn how even a single night of deprivation can spike harmful tau levels by 50%, effectively accelerating brain aging. The discussion pivots to dual orexin receptor antagonists (DORAs), a drug class that quiets wakefulness rather than forcing sedation. Matt highlights re...

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Episoder(186)

#149 - The 11 largest Sleep Myths

#149 - The 11 largest Sleep Myths

Debunking 11 sleep myths, Matt begins by explaining that the brain remains active, not "off," during rest. He goes on to argue that 7-9 hours of sleep is vital and warns that "adapting" to less is a d...

24 Aug 27min

#148 - Psychedelics for Mental Health

#148 - Psychedelics for Mental Health

Matt delves into how psychedelics like psilocybin and LSD quiet the "Default Mode Network" to boost neuroplasticity. He describes these molecules as a "crowbar" that allows therapy to break deep-seate...

17 Aug 32min

#147 - Does Sleep Really Clean Your Brain?

#147 - Does Sleep Really Clean Your Brain?

Matt explores the brain's secret plumbing, a waste-clearance network once ignored for over a century. He explains how the glymphatic system flushes metabolic toxins like amyloid-beta during sleep. Thi...

10 Aug 25min

#146 - How Sleep Changes Across the Human Lifespan

#146 - How Sleep Changes Across the Human Lifespan

Matt tracks sleep across the human lifespan, from newborn "active sleep" to the shifts of healthy aging. He explores how biological milestones - like puberty, pregnancy, and menopause - impact rest, r...

3 Aug 20min

#145 - How to get More Deep Sleep

#145 - How to get More Deep Sleep

Matt explains the science of deep sleep, emphasizing that this front-loaded stage is vital for physical and mental repair. To boost it, he recommends "builders" like consistent wake times, daily exerc...

27 Jul 32min

#144 - Face Blindness Explained

#144 - Face Blindness Explained

Matt explores how the brain constructs reality by examining neurological anomalies. He contrasts "super-recognizers" with those living with prosopagnosia, or face blindness. By analyzing the Capgras d...

20 Jul 28min

#143 - The Science of Love, Desire, and Sex

#143 - The Science of Love, Desire, and Sex

Matt examines the neurobiology of love, defining it as a reward system rather than just an emotion. He breaks love into three systems: lust (hormones), attraction (dopamine), and attachment (oxytocin)...

13 Jul 33min

#142 - How Memory Affects Sleep

#142 - How Memory Affects Sleep

Exploring how daily memories shape the biology of sleep, Matt reveals that, beyond consolidating facts, the brain's restorative depth is a response to daytime effort. By showing how learning deepens s...

6 Jul 29min

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