Special Episode: Lawrence Ingrassia & A Fatal Inheritance

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your lifetime, a condition known as Li-Fraumeni Syndrome. Journalist Lawrence Ingrassia belongs to one of those families; he has lost his mother, three siblings, and a nephew to cancer. In this TPWKY book club episode, Ingrassia joins me to discuss his book A Fatal Inheritance: How a Family Misfortune Revealed a Deadly Medical Mystery, where he weaves together his family’s story with that of the scientists who sought to uncover the cellular drivers of cancer. Tune in for a heartbreaking and inspiring journey.

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Episoder(299)

Ep 219 The Brown Recluse: Fearsome foe or slandered spider?

Ep 219 The Brown Recluse: Fearsome foe or slandered spider?

Few spiders hold the dubious honor of name recognition among the general public. Most that do, like black widows, Australian funnel-web, the Goliath birdeater, are renowned not for their cute colors o...

18 Aug 58min

Special Episode: Deborah Cohen & Bad Influence

Special Episode: Deborah Cohen & Bad Influence

If you have a medical question, where do you turn? How often is google or social media your first stop? As you sift through the AI overview and countless reels professing to have the answers, it becom...

11 Aug 51min

Ep 218 The Lowdown on Statins

Ep 218 The Lowdown on Statins

Last week, we set the stage by breaking down the science behind cholesterol: how it moves through our body, why it causes disease, and when we discovered the link between LDL and atherosclerosis. This...

4 Aug 1h 10min

Ep 217 The High Stakes of Cholesterol

Ep 217 The High Stakes of Cholesterol

So your latest blood test results have come in, and you see a couple of numbers for cholesterol. What do those numbers mean, and why do we care about them? In this first part of our cholesterol minise...

28 Jul 1h 3min

Ep 216 Cyclospora: Explosive Diarrhea Everywhere

Ep 216 Cyclospora: Explosive Diarrhea Everywhere

You’ve seen the headlines: a food-borne parasite is infecting people across the US, leaving them chained to the toilet sometimes for weeks on end, as they are ravaged by wave after wave of gastrointes...

21 Jul 54min

Special Episode: Alev Scott & Cash Cow

Special Episode: Alev Scott & Cash Cow

Social media ads for egg freezing. A craigslist-like site for breast milk. Fertility fairs featuring IVF clinics alongside shamanic nutritionists. Surrogacy contracts offering a discount for multiple ...

14 Jul 48min

Ep 215 The Hidden Depths of Earwax

Ep 215 The Hidden Depths of Earwax

In keeping with last week’s theme of “bodily excretions that are kinda gross that you don’t really think about but are actually really important”, we’re devoting this episode to earwax, aka cerumen. I...

7 Jul 54min

Ep 214 Boogers: Digging for treasure

Ep 214 Boogers: Digging for treasure

Hard and crusty. Green and gloopy. Clear and watery. Boogers come in a veritable rainbow of colors and a full spectrum of textures from liquid to solid. They’re really quite impressive if you think ab...

30 Jun 1h 2min

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